Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 718276 | Proximal interphalangeal arthroscintigraphy in rheumatoid arthritis. | 1978 Oct | Quantitative scintigraphy of proximal interphalangeal joints was performed by a reproducible method using 99m-Technetium in the hands of 40 normal controls and 20 patients with rheumatoid arthritis (RA). The range of the mean uptake varied considerably between proximal interphalangeal (PIP) joints in normal subjects. The mean uptake over PIP joints was not significantly different either between normal controls and RA patients, nor between those rheumatoid arthritis patients with and those without clinical signs of inflammation in the PIP joints. However, the variation in the PIP counts was significantly greater in the rheumatoid hands than in the normal hands. There was no clear correlation between the technetium uptake and the clinical parameters of inflammation in the PIP joints. | |
| 6824512 | Capacity to solubilize immune complexes in sera and synovial fluids from patients with rhe | 1983 Feb | Fifty-six sera and 33 synovial fluids from rheumatoid arthritis patients were studied to evaluate their capacity to solubilize immune complexes. A decreased function was found in 65% of rheumatoid synovial fluids when compared with 13 osteoarthritis synovial fluids. The decrease of immune complex solubilization capacity correlated with the decrease of hemolytic activity of the alternative complement pathway (P less than 0.001) and inversely with the level of immune complexes (P less than 0.05). Synovial fluids with low and normal immune complex solubilization capacity were compared; the results confirmed a possible role of the synovial complement system in modulating the size and thus the diffusion and clearance of locally generated immune complexes. | |
| 1020393 | [Results of different long term treatments of patients in the early stages of rheumatoid a | 1976 Nov 15 | In a clinical 5-year-study on 200 patients with rheumatoid arthritis with the help of the dynamics of radiological changes (radiological progressing), the joint deformation, the reduction of function and the new affection of joints (clinical progressing) as well as the medium position of activity the progressing of the disease and a good, satisfying or missing success of the long-term therapy were estimated. From the characteristics of the individual groups of therapy conclusions for the therapy in the early phase of the rheumatoid arthritis were derived. | |
| 1097845 | The viral theory of connective tissue diseases: a review. | 1975 Apr | For many years evidence for a viral aetiology of connective tissue diseases such as systemic lupus erythematosus and rheumatoid arthritis has been sought by a variety of methods, including attempts at direct isolation, the study of rheumatoid synovial cells, ultrastructural examination of pathological material and assays of anti-viral antibody. No convincing proof has yet been obtained. However, a better understanding of the mechanisms of viral persistence, and the ways in which host defences can be subverted by viral infections has prompted other ways of approaching this problem. A viral aetiology for this group of diseases remains an attractive but unsubstantiated hypothesis. | |
| 6606846 | Particularities of rheumatoid arthritis in aged people. | 1983 Oct | Forty patients with rheumatoid arthritis (RA) selected according to the ARA criteria, in whom the onset of disease had appeared after the age of 65 years, were studied comparatively with a control group of 40 RA patients in whom the disease had occurred before this age. Every patient was subjected to a complex clinical and biologic investigation. The characteristics of the two groups are presented. The onset of disease in old age was frequently acute (65% of the cases as compared with 45% in the control group). The difference between the two groups was statistically significant from this viewpoint (p less than 0.001). Presence at onset of certain general manifestations associated with loss of weight, risomelic involvement and association of Horton disease were found in 50% of the old agers as compared with 12.5% in the control group. The radiologic aspect was similar in both groups. Positive rheumatoid factor in 64% of the cases, as well as the homogeneous or speckled antinuclear factor were likewise comparable with the data in the younger group. From the evolutive point of view RA with onset in old age showed good response to therapy. Chrysotherapy was effective in 80% of the patients in the old age group and in less than 50% of the controls. | |
| 6978402 | Thyroid dysfunction and rheumatic diseases. | 1982 Feb | Musculoskeletal symptoms developing during the treatment of thyroid disease were studied in 150 patients; 17 developed a symptom complex of early morning stiffness together with shoulder girdle pain and weakness; similar symptoms were seen in only 3 of 100 controls. A prospective study of 16 patients with recent onset rheumatoid arthritis followed during the first 6 months of penicillamine therapy showed no changes in thyroid function tests. It is suggested that changing or abnormal thyroid status may precipitate or exacerbate musculoskeletal disease. Finally, in a retrospective study of 26 patients with both thyroid disease and rheumatoid arthritis, 4 patients had a simultaneous onset of both myxoedema and rheumatoid arthritis, the activity of which was greatly improved by correction of the hypothyroid state. | |
| 1079676 | [Multiple pseudoxanthomatour rheumatoid nodules]. | 1975 Mar | 2 cases of Rheumatoid arthritis associated with multiple subcutaneous nodules were presented, which resembled "pseudoxanthomatour rheumatoid nodules" as before reported. In the first case, the asymmetrical joint involvement has been preceded by the formation of subcutaneous nodules since 5 years; In the second case, arthritis appeared long before the nodules were formed. In both cases, circumscript vasculitis and high titer of rheumatoid factor were noticed and cystic activities were found in several nodules. | |
| 4063627 | Fenclofenac-induced selective IgA deficiency in rheumatoid arthritis. | 1985 Nov | A 35-year-old man with seropositive rheumatoid arthritis developed selective IgA deficiency during treatment with fenclofenac. His arthritis remained quiescent while taking the drug and following its withdrawal his condition relapsed and his serum IgA level returned to normal. This case demonstrates the association of selective IgA deficiency with remission in rheumatoid arthritis induced by fenclofenac as well as aurothiomalate and sulphasalazine. It also shows severe relapse after withdrawal of fenclofenac. | |
| 6487880 | Pulmonary manifestations of rheumatoid arthritis. | 1984 Oct | The catalogue of respiratory complications of rheumatoid arthritis has grown steadily in recent years. Physiological testing has highlighted surprisingly frequent asymptomatic disease while other respiratory problems are still rare. These and other pulmonary manifestations are discussed. | |
| 4784887 | Mycoplasma hyorhinis swine arthritis. 3. Modified disease in Piney Woods swine. | 1973 Dec | Piney Woods miniature swine, when injected with Mycoplasma hyorhinis, develop an acute arthritis. The disease in these animals is limited clinically, microbiologically, and pathologically to a mild acute illness without the more chronic and destructive features noted in a previous study of the experimental disease in Yorkshire swine. | |
| 7420339 | Characteristics of rheumatoid arthritis in a male population. | 1980 Jul | A population of males and females with definite or classical rheumatoid arthritis was studied. The males seem to have more severe disease with positive latex fixation, radiographic changes and rheumatoid nodules than is reported in the literature and the female comparison population. This difference can probably be explained because most studies have a female preponderance and our experience suggests that the disease is more severe in males. | |
| 6515540 | [Erroneous prescription of rumalon to rheumatoid arthritis patients]. | 1984 | The author describes 2 cases of erroneous prescription of rumalon to patients with rheumatoid arthritis (RA), as a result of which in one of the patients oligoarthritis arthritis while in the other one the typical seropositive slow-progressing rheumatoid arthritis transformed to RA with systemic manifestations. | |
| 7118975 | Synovectomy of the elbow in rheumatoid arthritis. | 1982 Sep | Twenty-five synovectomies of the elbow were performed in twenty-one patients with rheumatoid arthritis, and the patients were followed for two to eleven years. All patients had an advanced stage of the disease, with disintegration of cartilage and severe erosions of bone. The operations were performed by the same surgeon using the same technique. Follow-up studies revealed various degrees of improvement in all patients. The improvement in motion was most evident in rotation of the forearm. Pain was diminished in all but three patients. In five elbows a few degrees of flexion and extension was lost. The favorable response to synovectomy was retained throughout the follow-up period in twenty-four elbows. In only one elbow was there recurrence of the synovial swelling, about eight years after the operation. | |
| 1118560 | Pyarthrosis complicating rheumatoid arthritis. Roentgenographic evaluation of 5 patients a | 1975 Mar | Five patients with pyarthrosis complicating rheumatoid arthritis are described. Only minimal clinical signs may be seen in such patients, making accurate diagnosis of this occasional complication difficult. Roentgenographic abnormalities include a rapidly enlarging joint effusion and progressive cartilage and bone destruction. Fistulas may develop. The principal differential diagnoses include exacerbtion of rheumatoid arthritis and alterations in the rheumatoid joint following trauma. | |
| 686872 | Observer variation in examination of knee joints. | 1978 Aug | The knees of 20 patients with rheumatoid arthritis were each examined on two occasions on the same morning by three observers. Assessments were made of joint warmth, synovial thickening, effusion, instability, quadriceps power, bony enlargement, range of movement, and knee circumference, and were graded on a scale of 0-4. Analysis of the results shows close intraobserver agreement for all measurements but considerable interobserver variation for all subjective measurements. | |
| 975759 | Medical management of rheumatoid arthritis. | 1976 Oct | The overall management of RA is multifaceted. It includes rest, both systemic and articular; physical therapy; utilization of the techniques and appliances of occupational therapy; drugs, both those that suppress inflammation and those that are capable of altering the disease course itself; a knowledge of specific articular and nonarticular complications; and the ability to refer for appropriate surgical management. Judicious, energetic application of these principles can favorably affect the outcome of rheumatoid disease in most patients. | |
| 6678196 | Timegadine: long-term open study in rheumatoid arthritis. | 1983 Dec | The efficacy and tolerability of Timegadine, a new antirheumatic agent, administered at a dose of 250 mg twice daily was evaluated in an open trial of 24 weeks' duration in 31 patients with active rheumatoid arthritis. The subjective and objective clinical parameters improved significantly from the 2nd to 6th week of treatment. For some of the parameters further improvement was observed during the continuation of the treatment. At 6 weeks the ESR was significantly decreased, and a further reduction of the ESR was seen with the continuation of the treatment. At the end of the treatment period other humoral parameters of the disease were significantly modified. Moreover, in 65% of the patients with seropositive rheumatoid arthritis a reduction of the rheumatoid factor titre by at least two dilutions was observed. Five of the 31 patients were withdrawn from treatment due to the appearance of side effects. Although the study was open and the number of patients relatively small, the observed changes in the laboratory parameters of disease activity encourage further investigations to assess the potential of Timegadine as a remissive drug. | |
| 6718952 | The oxidation of serum sulph-hydryl groups by hydrogen peroxide secreted by stimulated pha | 1984 | Levels of free sulph-hydryl (SH) groups are depressed in the sera of patients with rheumatoid arthritis, especially during active disease. However, the mechanism underlying this effect is not known. We have investigated several oxidative species generated during the inflammatory process for their ability to react with serum SH in vitro. Our results show that serum oxidase enzymes (e.g. caeruloplasmin) do not have this activity but that "active oxygen species" generated either by an enzymatic reaction (xanthine plus xanthine oxidase) or by neutrophils stimulated with heat-aggregated IgG cause rapid oxidation of serum SH groups. The use of selective inhibitors of active oxygen species has demonstrated that this reaction is mediated by hydrogen peroxide. This compound is secreted in considerable amounts by activated phagocytic cells, especially neutrophils. Thus, serum SH levels may reflect phagocytic activity in patients with rheumatoid arthritis. We suggest that serum SH groups act as important extracellular scavengers of peroxides and so help to protect cells from damage by these molecules. | |
| 3986417 | Silastic sheet interposition arthroplasty for the painful rheumatoid wrist: a long-term re | 1985 Apr | Silastic sheet interposition arthroplasty was performed in 20 patients with persistently painful but stable wrists. Synovial recurrence with progression of symptoms was seen in one patient. Quantitative analysis of pain demonstrated an 87% improvement in their perception of pain in the remaining 19 patients, with an average follow-up of 8.5 years. The postoperative range of motion was 58 degrees Total Active range of Motion (TAM) (range 27 degrees - 97 degrees). Nine patients showed later ulnar translocation of the carpus, and 10 patients had continuing carpal collapse. There was no relation between these changes and the degree of pain relief at the radio-carpal joint. Those patients operated on within 18 months of the onset of symptoms showed a significantly greater post-operative range of motion (68 degrees) compared to those whose symptoms had persisted from 2 to 4 years (48 degrees). | |
| 3000794 | Long-term low dose ticlopidine treatment in rheumatoid arthritis: effects on serum sulphyd | 1985 | In 22 patients with rheumatoid arthritis oral ticlopidine 250 mg/day for 18 months induced clinical improvement, confirmed by a significant decrease in the counts of involved joint. A significant decrease was observed in the technetium index (Tc-index) and the erythrocyte sedimentation rate (ESR), and a significant increase occurred in the serum sulphydryl (SH) levels. The long-term changes in serum SH and Tc-index produced by ticlopidine may represent a specific antirheumatic activity of this platelet-inhibiting drug. |