Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 86342 | Serological abnormalities in families of patients with rheumatoid arthritis: eight to twel | 1978 | Serum gammaglobulin level, the presence of rheumatoid factor and of anti-nuclear antibodies were re-examined after 8 to 12 years in families of 21 seropositive rheumatoid arthritis patients. In the time 8 members of the families developed rheumatoid arthritis and the number of persons with elevated serum gammaglobulins increased. Rheumatoid tests yielded variable results. No relationship could be demonstrated between development of disease symptoms and the earlier presence of rheumatoid factor. | |
| 6895833 | Rheumatoid nodule formation within the choroid plexus. Report of a second case. | 1982 Feb | A woman with active systemic rheumatoid disease had striking neuropsychiatric manifestations; a rheumatoid nodule within the choroid plexus was the sole neuropathological finding. Although we found only one other report of findings of this type in rheumatoid disease, we suspect that this phenomenon may not be as rare as originally believed, and that it may represent another mechanism by which behavioral changes develop in this disorder. | |
| 6316477 | [Muscles and nerves in rheumatoid arthritis]. | 1983 Oct | The authors report the results of a systematic study of 37 hospitalized cases of rheumatoid arthritis. The neurological and muscular clinical signs are usually discrete. Electrophysiological examination is the basis for a classification in terms of the extent and the intensity of the neuropathy. Clinical and laboratory correlations are established permitting the individualization of a group of patients with severe neuropathy. The histological, morphometric and ultrastructural examination of 12 muscle and nerve biopsies reveal the high incidence of these lesions and the constancy of capillary involvement. | |
| 6673980 | Serum copper and caeruloplasmin are higher in seropositive than seronegative rheumatoid ar | 1983 | Increased serum copper (sCu) and alpha 2 caeruloplasmin (alpha 2 sCP) concentrations have been reported in patients with rheumatoid arthritis and other inflammatory conditions. Close parallel changes of sCu and alpha 2 sCP in rheumatoid arthritis have recently been observed by us in 30 subjects. The 'IgM rheumatoid factor positive (IgM-RF)' patients showed higher sCu and alpha 2 sCP concentrations when compared with 'IgM-RF negative'. Moreover a significant correlation was found between sCu alpha 2 sCP and other humoral indexes altered in rheumatoid arthritis. Therefore it seems useful, as further index of inflammation, to test both sCu and alpha 2 sCP. | |
| 6663604 | The coexistence of rheumatoid arthritis and giant cell arteritis. | 1983 Dec | Three cases of giant cell arteritis that developed in patients with known seropositive rheumatoid arthritis are described. The coexistence of these 2 conditions has been felt to be unusual. The diagnostic difficulties encountered when 2 such inflammatory conditions coexist are discussed. | |
| 597105 | Rheumatoid disease with involvement of the leptomeninges presenting as symptomatic epileps | 1977 Oct | A case of rheumatoid disease with localised granulomatous involvement of the leptomeninges is described. This meningeal disease apparently caused a symptomatic epilepsy. This is thought to be only the second reported case of rheumatoid granulomatous involvement of the leptomeninges. | |
| 6879096 | [Treatment of rheumatoid arthritis by plasma exchange]. | 1983 Apr | The authors treated 9 patients with rheumatoid arthritis by plasma exchange. In the 5 cases with purely joint involvement, the treatment was not effective, with one exception. In the 4 other cases, with polyneuropathy and vasculitis, plasma exchange resulted in a rapid regression of the symptoms. Thus cases of polyneuropathy and vasculitis due to rheumatoid arthritis are good indications for treatment by plasma exchange. | |
| 881691 | "Independent assessor" and "pooled index" as techniques for measuring treatment effects in | 1977 Summer | To conduct studies of therapy of rheumatoid patients at the primary care level two new assessment techniques were developed. The "independent assessor" (IA) was a nonmedical person trained to gather information using a questionnaire, a guided count of tender joints, grip strength, and blood tests. The "polled index" was a statistical device for summarizing all abailable information, constructed by transformation of various clinical measures of treatment effects to a common scale, based on standard deviation units. A validation study is reported, which involved 33 rheumatoid patients, each studied by four trained observers plus the IA, before and after 10 days of hospital therapy. Major gains in sensitivity and reliability were achieved by the pooled index. The IAs total assessment provided 84% of the information available in the pooled index, and was more sensitive and reliable than any other single clinical measure. The efficacy of a brief period of hospital therapy for rheumatoid patients was also strikingly demonstrated. | |
| 411771 | Amyloidosis in rhesus monkeys with rheumatoid arthritis and enterocolitis. | 1977 Nov 1 | Generalized amyloidosis was diagnosed by light and electron microscopy in 4 of 5 monkeys (Macaca mulatta) that had a history of chronic arthritis or chronic intermittent diarrhea, or both. Clinical signs and lesions of arthritis in the monkeys were compatible with diagnostic criteria for rheumatoid arthritis. Shigella sp was cultured from 1 monkey, and 2 other monkeys had colonic lesions characteristic of shigellosis. At necropsy, gross changes attributed to amyloid were seen only in the liver. Amyloid deposits in the liver, spleen, mesenteric lymph nodes, kidney, heart, adrenal glands, and other organs were determined by staining reactions and fine structural characteristics. | |
| 7123105 | Gout, pseudogout and rheumatoid arthritis in an elderly patient. | 1982 Jan | The simultaneous occurrence of gout, pseudogout and rheumatoid arthritis in a 62-year-old patient is reported. Diagnosis of the rheumatic disorders was supported by biochemical serological and microscopical findings. | |
| 446148 | Acute respiratory failure and pulmonary arteritis without parenchymal involvement: demonst | 1979 Apr | A 28-year-old woman with a eight-year history of rheumatoid arthritis presented with a three-day history of dyspnea. Physical and electrocardiographic findings were consistent with pulmonary hypertension. Arterial blood gases revealed a ventilation-perfusion mismatch. Chest roentgenogram was normal. After transient improvement, she suddenly deteriorated and died. At autopsy, a necrotizing pulmonary panarteritis was found without parenchymal involvement by rheumatoid disease. The pulmonary arteries were the only vessels affected. Immunofluorescent staining revealed immunoproteins scattered throughout the vessel walls without localization to the basement membrane. The unique features of the case are discussed in relation to pulmonary hypertension and rheumatoid lung disease in which vascular lesions are usually associated with honeycomb lung. The association between the rheumatoid arthritis and pulmonary vasculitis was probably coincidental. | |
| 438265 | Arthrodesis of the shoulder in rheumatoid arthritis: a review of forty-one cases. | 1979 May | Forty-one arthrodeses of the shoulder in thirty-nine patients suffering from rheumatoid arthritis (thirty women, nine men) have been reviewed. Using internal fixation and external splints the position of the shoulder was maintained in 55 degrees of abduction, 25 degrees of horizontal flexion and enough internal rotation to allow the patient to reach the mouth. The mean period of immobilisation in a thoracobrachial splint was nine weeks, and 90 per cent of the shoulders had solid bony fusion at review. After arthrodesis the total range of scapulothoracic movement improved by about 60 per cent, giving results rated as excellent in fifteen cases (36 per cent), as good in thirteen (32 per cent) and as fair in thirteen (32 per cent). Arthrodesis can be recommended as an easy, cheap and reliable method of treating a shoulder which has been severely destroyed by rheumatoid arthritis. | |
| 630948 | Mitral and aortic valve replacement in valvular rheumatoid heart disease. | 1978 Mar | Specific endocarditis involving the aortic and mitral valves in a patient with peripheral rheumatoid arthritis is reported. The patient underwent prosthetic replacement of both valves. Typical rheumatoid nodules were detected histologically in the valvular tissues. | |
| 3839381 | Rheumatoid arthritis with bloody and cholesterol pleural effusion. | 1985 Aug | We describe a case of rheumatoid arthritis complicated by unilateral adhesive pleurisy and associated with bloody and cholesterol effusion in a 47-year-old man. Our case emphasizes that the diagnostician needs to consider rheumatoid disease in a differential diagnosis of bloody pleural effusion in patients with associated joint disease. Adequate histologic confirmation of the underlying pathology is required for definite diagnosis. | |
| 6969972 | Radiographic progression of rheumatoid arthritis related to some clinical and laboratory p | 1980 | In 188 patients followed for 3 to 12 years, the radiologic course of rheumatoid arthritis was assessed in 20 joint groups. A severe course in most joints was related to the presence of rheumatoid factor and to high values of the ESR. Granulocyte-specific antinuclear antibodies were related to a severe course in most joints. The presence of nodules, the Rose-Waaler titre and the presence of organ non-specific antinuclear antibodies were generally unrelated to the course of the disease. | |
| 7161787 | The coexistence of rheumatoid arthritis and scleroderma: a case report and review of the l | 1982 Nov | We describe a patient with all the features of the CREST syndrome variant of scleroderma who developed a destructive arthropathy typical of rheumatoid arthritis (RA). A pulmonary rheumatoid nodule was found confirming the presence of RA. The rarity of the coexistence of these two diseases in the same patient suggests that, despite commonly found overlapping features, these illnesses are distinct entities. | |
| 6524185 | [The adaptation syndrome and causes of exacerbation in rheumatoid arthritis]. | 1984 | The electron neuromyography (ENMG) and clinical data were studied in 70 patients with rheumatoid arthritis during an exacerbation and remission. The pathologically changed ENMG data disagreed with subjective and clinical improvement seen during the remission. The patients' condition out of rheumatoid arthritis exacerbation is considered as a syndrome of unstable adaptation. Frequent exacerbations of rheumatoid arthritis are supposed to depend on unstability of the adaptation mechanisms during a remission. | |
| 968347 | Application of visual-analogue scales to the measurement of functional capacity. | 1976 Aug | Visual-analogue scales can be used to measure the subjective aspect of functional ability but, in a group of patients with severe rheumatoid arthritis, the severity of impairment of two predetermined functional tests was low in comparison with the severity of pain. Measurements of the ability to carry out these two functions, using visual-analogue and descriptive scales, and also using the time taken to perform the tasks, were not useful measures of the effectiveness of treatment of rheumatoid arthritis. Poor correlations were obtained between different measures of the same function and between different functions measured in the same way. | |
| 6532620 | Clinical features, scintiscan characteristics and X-ray progression of late onset rheumato | 1984 Apr | The clinical features, serology behaviour, scintiscan characteristics and the degree of X-ray progression according to the disease duration were compared in two RA groups with a disease onset after 65 years of age (LORA) and before 65 (EORA) respectively. No differences emerged in either the clinical findings or in the scintiscan picture. A sub-group of LORA showed acute flares of the illness presenting with very high ESR values and high fever. The erosive index (EI) evaluated in three areas (carpal-bone and wrist, MCP and PIP joints) revealed an undistinguishable degree of X-ray damage either in seropositive or seronegative patients, whereas seropositive EORA fared clearly worse than seronegative ones. A prospective study in two small sub-groups of LORA and EORA revealed a progression of X-ray erosions despite second line drug treatment in both groups, especially in LORA. | |
| 6660240 | Penicillamine: an anti-rheumatoid drug. | 1983 Dec 30 | Penicillamine is now established as a useful disease remittive drug in the treatment of rheumatoid arthritis. Improvement during a successful course of treatment may be found in a decrease in the degree of synovitis, which is associated with a reduction in the level of rheumatoid factor and immune complexes in serum and synovial fluid. Vasculitic lesions also resolve. There is roentgenographic evidence of healing of the erosive lesions after two to three years of treatment. The multiplicity of adverse effects caused by the drug limits its usefulness, although with increasing experience more patients are being treated successfully. The induction of autoimmune side effects in a small number of patients treated with penicillamine has elicited particular interest since this may represent a clue to its mechanism of action on the immune system. The over-all approach to the use of the drug, including currently accepted methods of dosing and safety monitoring, is reviewed. |