Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 7331862 | Radiologic evaluation of synovectomy in rheumatoid arthritis. | 1981 | The course of radiologic rheumatoid arthritis changes in 14 proximal interphalangeal joints of the fingers, 11 metacarpophalangeal joints and 16 knees that were subjected to synovectomy was compared with non-synovectomized joints that were suitable for matching, according to clinical, laboratory and radiologic criteria. The progression of radiologic involvement was probably not changed by synovectomy. | |
| 1198075 | Generalised and localised bone loss in patients with rheumatoid arthritis. | 1975 | Osteoporosis was studied in 307 patients with "definite" or "classical" rheumatoid arthritis by measurement of the clavicular cortical thickness (C.C.T.). Bone loss, as measured by this index, fell with advancing age, and was significantly greater than in non-rheumatoid control subjects matched for age and sex. Bone loss from the clavicles was not greater in patients treated with corticosteroid drugs. Loss of bone from the clavicle correlated with osteoporosis in other parts of the skeleton, as determined by the femoral and metacarpal indices. This suggests that osteoporosis in rheumatoid arthritis is a generalised phenomenon rather than a localised process secondary to adjacent joint inflammation. | |
| 6966867 | [Lymphocyte blast transformation according to the clinical variant of rheumatoid arthritis | 1980 | Blast-transformation reaction of lymphocytes to non-specific stimulation with phytohemaglutinines was studies in 83 patients with rheumatoid arthritis with different activity of the general inflammatory reaction, stage and form of the disease. Lymphocytes react with diminished activity to that stimulation both in the early and late stages of the disease, being an index for the intransience of the conditions for antigen stimulation. The diminished lymphocyte reaction correlates with the clinical-laboratory indices for activity of rheumatoid arthritis. It raises in the course of the medicament tosus effect and reflects the effectiveness of treatment. The cellular immunity takes part in the pathogenesis of rheumatoid arthritis. Blast-transformation test could be used as an aide in the determination of rheumatoid arthritis activity as well as of the cellular immunity state. | |
| 1201650 | Large subarticular cysts (geodes) adjacent to the knee-joint in rheumatoid arthritis. | 1975 Oct | Two patients with rheumatoid arthritis are described, who developed very large bone cysts or geodes adjacent to the knee-joint. The existence of cysts adjacent to joints involved by rheumatoid arthritis is well recognised, but the occurrence of very large cysts is unusual and may present diagnostic difficulties. Possible aetiological factors are discussed. | |
| 7457185 | Evaluation of the progression of rheumatoid arthritis. Significance of age at onset and se | 1980 | The limb joints of 188 patients with rheumatoid arthritis were classified according to the LARSEN scoring system. The mean degree of involvement was approximately a linear function of the square root of the duration of the disease. A mild course in the elbows and metacarpophalangeal joints, and a severe course in the distal interphalangeal joints of the fingers and toes were related to age over 40 years at onset of the disease. A severe course in most of the hands occurred in women. | |
| 426526 | Subcorneal pustular dermatosis and crippling arthritis. | 1979 Feb | A 25-year-old woman has suffered with subcorneal pustular dermatosis and a rheumatoid-like arthritis for the past 11 years. Both her skin lesions and arthralgia have abated with institution of dapsone administration and have worsened with interruption or reduction of the dose. The coexistence of arthritis and subcorneal pustular dermatosis and the response of both to therapy suggest a probable association. | |
| 3998055 | Problems in the classification of cause of death diagnoses affecting the reliability of mo | 1985 | The uniformity of physicians' diagnostic language on death certificates involving rheumatoid arthritis (RA), and its influence on the medical classification and on the mortality statistics was investigated. The point of departure was a disagreement between physicians' reporting of RA on death certificates and the Swedish National Central Bureau of Statistics' (NCBS) registration of this condition, to the effect that the NCBS registered a threefold mortality increase for women and a twofold increase for men attributed to RA between 1971 and 1975, whereas the physicians had reported practically no change at all for women and a slight decrease for men between the years. It is investigated in the present study to what extent this increased NCBS registration of RA as the underlying cause of death could be explained by physicians' diagnoses for underlying non-RA conditions being disregarded in favour of RA due to classification problems with the former diagnoses. All Swedish RA death certificates for the years 1971 and 1975 were studied. A total of 1224 such death certificates were identified. Physicians' diagnostic language was found to be strongly individualistic. Out of the total of 1666 diagnostic expressions 1229 (74%) had been used only once. The corresponding proportions were 76% in 1971 and 73% in 1975. Thus, there was practically no change in the linguistic individualization between these years. The 1666 expressions could be coded by 287 ICD 8 codes. One hundred and thirty-nine different expressions had been used for rheumatoid arthritis (ICD 8 code 712.3). One hundred and fifty-six (13%) of the death certificates contained diagnostic expressions encumbered with one or more of four major kinds of classification problems: (1) Expression(s) without ICD 8 code (24 certificates); (2) Expression(s) with several codes, uncertainty about which to select (45 certificates); (3) Expression(s) with several codes, one is preferable according to the ICD (39 certificates); and (4) Expression(s) which can be coded both by one specific code and by several codes (60 certificates). In one third (35%) of these cases the expression used referred to an underlying cause of death. The alternative interpretations of all these expressions differed in most cases on a three-digit level and in some cases on chapter level in the classification. Clarification of ambiguous expressions were solicited by the NCBS in only one case in 1971 and one in 1975. The NCBS' increased registration RA as the underlying cause of death between 1971 and 1975 could not be explained by problems of classification. | |
| 7323952 | Protein synthesis in rheumatoid synovial tissue. | 1981 | 1. Function of synoviocytes and other cells in the synovium A. Histologic Considerations 1. Electron microscopic studies 2. In vivo and in vitro phagocytosis studies 3. Fluorescent antibody staining B. Culture techniques 1. Problems posed by study of isolated cells 2. Long-term explant cultures 3. Advantages of short-term incubations of synovial fragments 4. Isolation of immunoglobulins C. Non-Immunoglobulin Products of the Synovium 1. Products of normal synovium 2. Alterations induced by rheumatoid arthritis II. The Local Immune response in Rheumatoid Synovitis A. Evidence for Active Immune Stimulation 1. Meditators of cellular immunity in synovial fluid 2. Effect of synovectomy 3. Type and amount of immunoglobulin produced B. Local Commitment of Antibody Response 1. Effect of exogenous immunization 2. Rheumatoid factors. 3. Pepsin agglutinators C. 1. Relative enrichment for IgG-3 subclass 2. Increase in lambda-light chain composition III. Pathogenetic Considerations in Rheumatoid Arthritis A. Comparison of Rheumatoid versus Experimental Immune Synovitis 1. Chronic synovitis as a local immune response. 2. Role of cartilage complexes in substaining chronic synovitis B. Significance of the Restriction in the Immunoglobulin Response in Rheumatoid Arthritis 1. Analogy with other disease states in man 2. Common antigen in RA? | |
| 434712 | [Pseudotumoral rheumatoid coxitis (author's transl)]. | 1979 | Two cases of rheumatoid coxitis of the macrogeodic type are reported. In one case, there was a very large anfractuous cavity in the socket and head, complicated by a pathological fracture of the socket, which raised the suspicion of a malignant tumor. The authors review the characteristics of these macrogeodic forms of rheumatoid arthritis, about forty cases having been reported in the published literature. | |
| 1211213 | Skeletal status in patients with rheumatoid arthritis. | 1975 Dec | The total body calcium - estimated from the bone mineral content in the distal part of the forearm, measured by means of photon absorptiometry - has been determined in 15 patients with rheumatoid arthritis. None of the patients were treated with steroids and all were relatively mobile. The results indicate that osteoporosis is uncommon in such patients. | |
| 6596704 | Epidemiological investigations on rheumatoid arthritis in Stockholm. The use of different | 1984 | The general aim of the thesis was to see how different data sources available in Stockholm County could be used for epidemiological investigations on rheumatoid arthritis (RA). The specific aims were: to study the mortality among persons with RA and the causes of the postulated high mortality in RA, to study the possible preventive effect of oral contraceptive use on the incidence of RA and to study the quality of the in-patient register with regard to RA. Four sources were used: An epidemiological survey of RA in Stockholm, the in-patient register of Stockholm County, the Stockholm County sample of the national health interview survey and the national cause-of-death register. These data sources were compared and validated against each other and other data collected. The possibilities and limitations in the use of these different sources were assessed in a series of epidemiological investigations of which the main findings were the following: Persons with RA had an increased mortality compared to the general population. This applied to persons with RA identified in a random sample from the general population as well as to persons hospitalized with RA. The excess mortality was particularly high in the hospitalized group. RA was rarely recorded as the cause of death. The mortality was strongly correlated to the severity of the disease, and drug use was not found to be the main cause of the high mortality. There was a slight reduction in incidence of RA among oral contraceptive users compared with non users, particularly for women with age at onset of RA over 40. At least 80% of the cases recorded as RA in the in-patient register were judged to be "true" cases of RA. The documentation of the cases as well as the accuracy of the diagnosis varied strongly between different types of departments. | |
| 31141 | Gamma glutamyl transpeptidase levels in arthritis: a correlation with clinical and laborat | 1978 Oct | Gamma glutamyl transpeptidase (GGTP) was measured in 62 patients with rheumatoid arthritis (RA) and 27 with osteoarthrosis (OA). The values for GGTP were significantly higher in the subjects with RA compared with the OA group. The prevalence of elevation of GGTP was higher in the RA subjects (77%) than in the OA patients (33%). Levels of GGTP correlated significantly with a number of objective indices of activity of RA in a separate group of 28 patients. Following treatment with penicillamine, GGTP levels showed a significant drop towards normal levels. | |
| 6614849 | Surgery of the elbow joint in rheumatoid arthritis. | 1983 Apr | A review is made of the literature of the mechanics of the elbow joint and the types of operations available. It is clear that the elbow is a complex joint and that in patients with rheumatoid arthritis destruction and disability occurs relatively late in the disease. Of the operations available, synovectomy and excision of the radial head are best done early in order to obtain the movement of supination and pronation. Total elbow replacement, particularly the unconstrained type is producing encouraging results and seems rational in view of the structure of the elbow. However it is early days in the design of these prostheses and the clear message is that the patients need full assessment in the light of their other joints involved. | |
| 1126071 | Surgery of the shoulder in rheumatoid arthritis. A report of nineteen patients. | 1975 Jan | Surgery of the shoulder has been neglected in the treatment of rheumatoid arthritis. Nineteen patients are reported to demonstrate that if conservative management fails, surgical treatment is indicated and worthwhile. | |
| 265651 | [Systemic manifestations in rheumatoid arthritis. A multivariate analysis of 122 patients | 1977 | In a retrospective study the case reports of 122 patients with rheumatoid arthritis (RA), were analyzed by computer with respect to systemic manifestations and the possible relationship of these manifestations to clinical findings. Bromsulphthalein retention, lung and kidney function were studied in other smaller unselected groups of RA patients and the results compared with the relevant clinical data. It was observed that nearly all systems can be involved in RA. High rheumatoid factor titres seem to be of great importance with regard to prognosis, but the duration and activity of the disease do, however, also influence the occurrence of systemic complications. Functional impairment of the different organs investigated was found in a high percentage of RA patients. Usually these disturbances are subclinical and not of great significance to the patient. Effects of antirheumatic drug therapy are difficult to evaluate, but they obviously do play an important role in the aetiology of the observed functional disturbances. Nevertheless, it must be stressed that the detection of systemic manifestations and functional disorders at the earliest possible stage of the disease is needed in the determination of the therapy of choice and is of great prognostic importance, thereby justifying detailed and often costly investigation. | |
| 520034 | Cutaneous manifestations of rheumatoid arthritis. | 1979 Nov | Rheumatoid arthritis (RA) is a systemic illness defined and classified according to strict criteria of the American Rheumatism Association. Cutaneous disease may complicate RA or the drugs used in its treatment. Cutaneous vasculitis is potentially a prognostic factor in patients with RA. Controversy exists regarding the role of corticosteroids in the development of rheumatoid vasculitis. Two illustrative cases of RA with cutaneous complications are presented and the joint and cutaneous manifestations are reviewed herein. | |
| 6610048 | An immunogenetic study of older age onset rheumatoid arthritis. | 1984 Apr | Thirty-two patients with older age onset rheumatoid arthritis (ORA), defined as disease onset after age 60, were selected for HLA typing. The majority (69%) were rheumatoid factor (RF) seronegative. An increase in HLA-DR4, though not statistically significant, was seen in ORA (38% vs 17% normals). This antigen was strongly associated with RF seropositivity (70%, p less than 0.01) and rheumatoid nodules (75%, p less than 0.01) in ORA. We conclude that the immunogenetics of ORA are similar to that described for adult RA in general. | |
| 6385205 | The influence of D-penicillamine therapy on numbers of circulating immunoglobulin secretin | 1984 | Higher numbers of plaque forming (immunoglobulin secreting) cells have been reported among peripheral blood mononuclear cells from patients with active rheumatoid arthritis than from patients with spontaneously inactive disease. Patients treated with D-penicillamine who showed a good clinical response were found to have lower numbers of circulating plaque forming cells than were detected in the active rheumatoid group. Similar numbers of plaque forming cells were detected in patients who showed a poor clinical response to D-penicillamine as in the active rheumatoid group (untreated with 'second line' drugs). Active rheumatoid arthritis is associated with increased numbers of plaque forming cells in the peripheral blood, changes in the numbers of these cells providing an index of disease activity. | |
| 6158572 | Beta-2-microglobulin in synovial fluid of rheumatoid arthritis. | 1980 Jul | The concentration of beta-2-microglobulin was determined by radioimmunoassay in the synovial fluid of 12 patients affected with rheumatoid arthritis and in 10 with other arthropathies. The white cell count, total protein concentration, total hemolytic activity of complement and acid phosphatase activity were also determined. Only beta-2-microglobulin was found to be significantly higher in rheumatoids compared to non-rheumatoid cases. In contrast, the other parameters showed no significant differences between the 2 groups of patients. These preliminary observations suggest that the measurement of beta-2-microglobulin concentrations in synovial fluid may be of diagnostic value. | |
| 3898295 | Rationale for thymopentin as therapeutic agent in rheumatoid arthritis. | 1985 | Etiology and pathogenesis of rheumatoid arthritis (RA) is reviewed, with special emphasis on immunological factors. A common feature in active RA seems to be the decreased T cell suppressor/cytotoxic response, also reflected in an increased OKT4/OKT8 ratio. As the presence of several subgroups in patients is possible, the therapeutic approach may differ accordingly. Different disease-modifying antirheumatic drugs (DMARDs) are discussed in this context; their most characteristic features are slow onset of action (i.e., after several months) and improvement in immunological parameters. Although thymopentin does possess the latter property, it is not considered a DMARD at the present time. The action of thymopentin sets in within a few weeks, and it is speculated whether this may be due to its possible hormonal effects (via beta-endorphins, prostaglandins, etc.). |