Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 1124957 | Lack of correlation of synovial histology with joint damage in rheumatoid arthritis. | 1975 Feb | Twenty-two patients with rheumatoid arthritis (RA) involving the knee were studied. The systemic features of the disease were graded and the extent of knee involvement was quantified in terms of the clinical, radiological, and arthroscopic appearances. Adequate synovial biopsies were obtained from 21 patients. In these patients no correlation could be found between the severity of any of the features on histological examination nor between any of these features and the extent of local joint damage, inflammation, or the severity of the systemic disease. | |
| 231829 | [Circulating immune complexes in rheumatoid arthritis. Results of a personal research (aut | 1979 Oct 18 | Using the technic of Pillot and Grangeot (précipitation by PEG 6,000 at 2.5%, followed radial immuno-diffusion), the authors have detected circulating immune complexes (CIC) 38 times in a group of 55 RA. The presence of CIC is significantly more frequent in sero-positive RA, but without correlation between the concentration of CIC and the positivity rate of Waaler-Rose reaction. There is no correlation between the evolutive state of RA and the presence or the concentration of CIC. The sedimentation rate is, in mean, significantly higher in RA with CIC; but, among these, there is no correlation between sedimentation rate and the concentration of CIC. In the group studied, the CIC are present in all cases of RA with vasculitis or visceral symptoms. | |
| 455728 | Determination of D-penicillamine in serum and urine of patients with rheumatoid arthritis. | 1979 Jun 1 | A chromatographic auto-analyser method is described for the determination of total D-penicillamine in biological fluids. After oxidation with performic acid, D-penicillaminic acid is separated from other ninhydrin-positive acidic amino acids by anion-exchange chromatography. Total cysteine/cystine is simultaneously determined as cysteic acid, which makes the method equally suitable for patients with cystinuria. The detection limit in serum and urine is 2 microM D-penicillamine, which is more than sufficient for clinical application. The metabolite S-methyl-D-penicillamine is oxidized by performic acid to a sulphone, which can be determined after separation by cation-exchange chromatography. | |
| 676798 | Soft tissue radiography for evaluating clinical activity of rheumatoid arthritis. | 1978 | The value of soft tissue radiography in assessing the activity of rheumatoid arthritis was investigated in 67 patients and correlated to the clinical activity of the disease. Soft tissue radiography using a technique for mammary radiography was combined with immersion. Radiologically demonstrated periarticular oedema was most closely correlated to clinical activity. A close correlation also existed between soft tissue radiographic lesions and 99Tcm accumulation in hands. | |
| 1202609 | Screening of cellular immunity in patients with rheumatoid arthritis by phytohaemagglutini | 1975 | Phytohaemagglutinin (PHA) skin test was used for screening of non-specific cell-mediated immunity in 30 patients with rheumatoid arthritis (RA) and its results compared with those obtained in age- and sex-matched controls with non-inflammatory rheumatic diseases. Purified protein derivative (PPD) of M. tuberculosis was used for testing of specific cell-mediated immunity in the same two groups. The reactivity to both PHA and PPD was found to be significantly lower in patients with RA, indicating the decreased cell-mediated immunity in this disease, as compared to controls. | |
| 7310781 | Circulating immune complexes in patients with rheumatoid arthritis: correlation with disea | 1981 Sep | Circulating immune complexes (CIC) have been detected in the majority of patients with rheumatoid arthritis (RA). Their usefulness in monitoring disease activity is still controversial. Thirty-five patients with RA have been studied for the presence of CIC by the C1q binding assay. Abnormally high levels of CIC were detected in 83% of the patients and in 76% of 46 serum samples. Mean C1q binding activity for all serum samples was 27.4 +/- 25 compared to 7.5 /+- 2% in a control group of healthy individuals. A highly significant correlation was observed between C1q binding activity and the following indices of disease activity: the erythrocyte sedimentation rate, the latex and Rose-Waaler tests and a systemic index. The level of CIC in RA patients seems to be a reliable index of disease activity. | |
| 921150 | Shrinkage of conjunctiva, Terrien's marginal degeneration, and perforation of cornea in rh | 1977 Oct | The unusual occurrence of severe conjunctival shrinkage resembling ocular pemphigoid and bilateral Terrien's marginal degeneration of the cornea in rheumatoid arthritis is described. In less than two years the right eye was lost due to spontaneous corneal perforation and the left became totally blind because of scarring and shrinkage of the conjunctiva. A common unknown factor is speculated as an etiologic relationship between rheumatoid arthritis, ocular pemphigoid, and Terrien's marginal corneal degeneration. | |
| 6697067 | The relationship of plasma and serum viscosity to disease activity and smoking habit in rh | 1984 Feb | Viscosity measurements of serum and plasma have been suggested as improvements on other indicators of activity in the rheumatic diseases. We compared the clinical assessment of disease activity in 71 patients with rheumatoid arthritis against various laboratory tests including viscosity measurements. The effects of smoking were also studied. While many of the tests showed correlations with each other, none was found to correlate with any of the clinical parameters. Smoking lowered the ESR, but did not affect the plasma viscosity in these patients. Thus viscosity measurements were no improvement in assessing activity in a cross section of patients, though its lack of dependence on smoking habit may be an advantage in sequential studies. | |
| 7097682 | Synoviorthesis with 32P-colloidal chromic phosphate in rheumatoid arthritis--clinical, his | 1982 Mar | Synoviorthesis was performed in 217 joints from 111 patients suffering from different stages of rheumatoid arthritis (RA). 32P-colloidal chromic phosphate was employed, with an average dose from 6 mCi for large joints (knees) to 0.3 mCi for small peripheral joints such as average dose from 6 mCi for large joints (knees) to 0.3 mCi for small peripheral joints such as the MCP or PIP joints. Satisfactory clinical results were observed in 84% of the cases and no significant side effects resulted after a follow-up period from 1 to 10 years. Striking effects after treatment were observed through histopathological studies (light and electron microscopy) and the use of contrast arthrography. We concluded that radioactive synovectomy with 32P-chromate is a very useful method for the local treatment of RA. | |
| 6614842 | Surgery of the rheumatoid hip. | 1983 Apr | The incidence and pattern of involvement of the hip in rheumatoid arthritis are reviewed. The criteria for the selection of patients for surgery are described and the points in preparation emphasised. The surgical procedures available are discussed with the results and complications to be expected. The clinical results of total replacement arthroplasty are gratifying despite the increased incidence of infection and mechanical loosening compared with osteoarthritic hips. | |
| 227098 | [The lateral atlantoaxial joint involvement in the rheumatoid arthritis. Report of ten cas | 1979 May 18 | An analysis of ten recent observations of lateral arthritis of C1-C2 during the course of rheumatoïd arthritis. This lesion, which is not rare, has charactéristic symptoms: localized pain together with occipital (Arnold's) neuralgia and specific blocking of head rotation towards the afflicted side. Frontal per-oral radiography shows joint line lesions most often unilateral, and a displacement of C1 towards the non afflicted side with pseudoinclination of the odontoïd process towards the afflicted side. Sometime more destructive lesions of the lateral masses of the atlas give them a triangular form and this may result eventually in an upwards "vertical" displacement of the odontoïd. The pain usually subsides in a few weeks after a conservative treatment with or without temporary immobilisation by a light removable cervical collar but the loss of the homolateral rotation of the head persists. Besides occipital (Arnold's) neuralgia, there seems to be no other neurologic complications; if they follow, it is due to an associated anteroposterior displacement. | |
| 6450900 | Gold therapy in arthritis treatment. | 1981 Jan | The purpose of this article is to familiarize primary care providers with the use of gold salts in the treatment of rheumatoid arthritis. Gold salts used carefully can be very effective in controlling the disease when used in conjunction with other anti-inflammatory medicines. Side effects of gold therapy can be potentially dangerous; but used cautiously, gold can be of great value in the treatment of rheumatoid arthritis. The dosage schedule of gold salts described in this article is the current method of administering gold salts. The side effects--dermatological, hematological, and renal are described, and the parameters that need to be followed are also included. The flow sheet in the article can be used by health care providers as a part of the medical record in which lab results and amount of gold can be kept current. The article also emphasizes that a nurse practitioner should be aware of the emotional and financial status of the patient. | |
| 7424201 | The diagnostic significance of certain histopathologic changes for rheumatoid arthritis. | 1980 Mar | As a practical and unequivocally pathognomonic sign for RA could serve a histopathologic change which both displays a conspicuous morphologic distinctiveness and occurs with an overwhelming frequency in RA versus an insignificant or absent frequency in other categories of synovitis. Such postulates were not fulfilled by any of the herein described histopathologic changes. Therefore, no absolutely or indisputably pathognomonic feature may be asserted for RA, although it must be recognized that highly suggestive or indicative significance has to be acknowledged for some of the herein listed histopathologic changes of the synovial membrane. | |
| 1202607 | Thermal inactivation and gradient studies of the active agent in rheumatoid arthritis. | 1975 | Ten day embryonated eggs have been used for testing supernatants of pooled RA synovial tissues for the presence of the RA-active agent. A high thermal resistance of the agent was observed up to 40 min of heating both at 100 and 121 degrees C with complete loss of infectivity only after 60 min at 121 degrees C. The high thermal resistance at 121 degrees C suggested that the active agent does not depend on a double-stranded DNA or RNA. It probably has no protein component and has a minimal number of subunits for replication. The CsC1 ultracentrifugation identified a concentration of high infectivity at densities in the range of 1.440-1.490 g/ml in five experiments. | |
| 414082 | [Hypothesis for the use of levamisole in rheumatic diseases (author's transl)]. | 1977 Nov 18 | For years the treatment of rheumatoid arthritis has been based on the assumption that the autoimmune processes and bone lesions occuring in rheumatic patients are due to inflammatory and immune reactions. Treatment was aimed at restricting these reactions. But various investigators have come to the conviction that the primary factor is not an immunological hyperreactivity but an immunodeficiency in autoimmune diseases. The immunotherapeutic use of transfer factor, BCG and levamisole in patients with rheumatoid arthritis is based on this hypothesis. From the fact that a therapeutic effect is demonstrable in such patients treated with levamisole, the theory that rheumatoid arthritis is an immunodeficiency disease should be accorded greater importance. | |
| 4071434 | [Anti-inflammatory and immunosuppressive effects of laser therapy in patients with rheumat | 1985 | The clinical and laboratory findings were examined of 10 patients with seropositive rheumatoid arthritis (RA) treated with a first applied technique of intravenous irradiation of the circulating blood with helium-neon laser combined with external irradiation of the inflamed joints. A distinct antiinflammatory and immunosuppressant effect was attained in all the RA patients. In 80% of the test subjects, the rheumatoid blood factor reduced to 1:20 titres. The treatment method did not cause any side effects or complications and shortened the time of the patients' stay at hospital. | |
| 7361023 | The clinical assessment of joint inflammatory activity in rheumatoid arthritis related to | 1980 Feb | A simple clinical method for the assessment of joint disease activity is described, and analysed with respect to radiological progression of erosive disease. Ninety-four patients with rheumatoid arthritis attending a special research clinic as part of a prospective study were studied over a three-year period. A significant correlation was found between clinical activity, assessed at intervals of four months, and progressive erosive disease but not with juxta-articular osteoporosis. This clinical method compares favourably with a modification of the articular index described by the Cooperating Clinics of North America. | |
| 4004363 | Rheumatoid bursitis extending into the clavicle and to the skin surface. | 1985 May | A woman with rheumatoid arthritis developed persistent sterile drainage from a cutaneous fistula after biopsy of an inflamed supraclavicular mass. Radiographs showed several cavities in the underlying clavicle. Inability to culture a pathogen and failure of the fistula to heal despite empirical courses of antibiotic therapy led to surgical intervention. The final diagnosis, based on careful histological analysis by special staining techniques, was rheumatoid bursitis extending into the clavicle and to the skin surface. | |
| 3978894 | Measurements of red blood cell methotrexate concentrations and lymphocyte subsets during t | 1985 Jan | Nine patients with rheumatoid arthritis were treated with low dose oral weekly methotrexate for 6 months. Successful therapy was not associated with changes in concentrations of total circulating lymphocytes nor with alterations of T lymphocytes in the helper-inducer, OKT4, or cytotoxic-suppressor, OKT8, subpopulations. Concentrations of methotrexate in circulating erythrocytes stabilized by 1 month of therapy and this measurement did not correlate with clinical efficacy or methotrexate toxicity in the long-term patient assessments. | |
| 3995216 | Comparison of reconstructive orthopaedic surgery in patients with seropositive and seroneg | 1985 May | The longitudinal orthopaedic history of 107 unselected patients with rheumatoid arthritis undergoing reconstructive surgery was studied to define the relationship between serology and surgery. Using strict criteria 85 patients were seropositive and 22 seronegative. Age, disease duration, number of reconstructive orthopaedic operations, and second-line or corticosteroid drug treatment were similar in seropositive and seronegative patients. Users of steroids and/or second-line drugs had a similar number of operations to non-users. However, patients undergoing only hip or knee surgery used steroids more often in the pre-operative disease than those only having other operations (p less than 0.05). This may reflect more-aggressive disease or the direct effect of steroids. The expected proportions of seropositive and seronegative patients together with their similar surgical and treatment patterns do not suggest that they have different diseases. |