Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 6981593 | The application of an extract of human placenta in the treatment of rheumatic affections. | 1982 | Iontophoretic application of Placenta-Lucchini in combination with catalase and mucopolysaccharidase for the treatment of acute rheumatic inflammation results in significant clinical improvement. Such improvement is not seen if Placenta is used alone. Intra-articular application of Placenta in the arthritis joints of patients with rheumatoid arthritis results in a significant improvement as compared with placebo. Its efficacy is, however, inferior to that of Triamcinolone. Intra-articular application of Placenta prolongs local arthritic remissions induced by steroids. | |
| 21511 | [Cogan's syndrome]. | 1977 | Since Cogan described his first case in 1945, about 50 cases have been published in the world literature, A 23 year old patient who suffered from this disease led us to make a detailed study of previous publications. The cochleo-vestibular, the etiological and the ophtalmical aspects of the case were studied, and, also the differential diagnosis and the therapeutical possibilities. | |
| 3937234 | [Long-term tolerance of oral gold therapy in rheumatoid arthritis. Frequency and intensity | 1985 Dec 7 | In view of encouraging results from various reliable multicenter studies, an interesting new oral agent, auranofin (triethylphosphine gold), is believed to be a major advance towards more effective treatment of rheumatoid arthritis with mild adverse reactions. The present study evaluates the long-term efficacy of auranofin in 46 patients with active rheumatoid arthritis and attempts to delineate further the results of drug monitoring concerning adverse reactions. Six patients withdrew due to untoward and partially serious events, e.g. thrombocytopenia, colitis or pancreatic disease. In view of the high frequency of side effects which required immediate withdrawal of auranofin in 13%, with a total of 37% of patients experiencing adverse reactions, it should be kept in mind that oral gold therapy may be a two-edged sword and requires further critical drug monitoring. | |
| 629608 | Synovial fluid copper and related variables in rheumatoid and degenerative arthritis. | 1978 Feb | Copper, caeruloplasmin, transferrin, albumin, and total protein were measured in the serum and synovial fluid of 40 patients with rheumatoid arthritis and 40 patients with osteoarthrosis. A raised synovial fluid copper and caeruloplasmin have been found to be characteristic of rheumatoid effusions. The relation between copper and caeruloplasmin in synovial fluid differs from that in serum. Synovial fluid caeruloplasmin was increased disproportionately in relation to other plasma proteins present in rheumatoid effusions. | |
| 6221365 | [Treatment of inflammatory hip disease in rheumatoid arthritis with cemented total prosthe | 1982 | The authors have operated on 62 hips in 43 patients. Thirty-eight were followed for more than three years. Out of 62 cases there were 2 early deaths, 2 instances of pulmonary embolus and 1 of sepsis. Five different types of prosthesis were used. On 11 occasions a border appeared around the cement of the femoral component and in three of these loosening was demonstrated. The number of these appeared to be higher than after total replacement for other etiologies and seemed to be aggravated by technical errors, such as varus positioning and lack of cement. In most cases a remarkable functional improvement was obtained but progressively secondary worsening of walking ability was seen due to involvement of other joints. It is concluded that special precautions should be observed in such cases and that other joints should be replaced earlier when necessary. | |
| 929123 | Connective tissue activation by synovial fluids and synovial-tissue extracts of rheumatoid | 1977 | Prompted by Castor's investigations (4) on a connective-tissue-activating peptide (CTAP) we investigated the stimulative effect of synovial fluids and synovial-tissue extracts on the synthesis of collagen by incubated embryonic-chick tendon cells. The stimulative effect was greater with synovial-tissue extracts from more severe cases than with samples from patients having milder forms of the disease. There was no correlation between the stimulation by synovial fluids and synovial-tissue extracts from the same patient. The stimulative activity was lost at dialysis. A slight stimulation in the incorporation of glucosamine was also observed. Treatment of the patients with gold, chloroquine or steroids decreased the stimulating capacity. These effects seem to depend on factors different from those described by Castor. The differerences in the stimulant activity of samples from various groups cannot be entirely due to glutamine, which is one of the limiting nutrients of the embryonic-chick tendon cells. | |
| 6729517 | Stress and coping in the explanation of psychological adjustment among chronically ill adu | 1984 | This study evaluates the utility of a stress and coping paradigm for explaining individual differences in psychological adjustment to chronic illness. Using data from the first wave of a longitudinal study of 170 middle-aged and elderly adults faced with one of four chronic illnesses (hypertension, diabetes mellitus, cancer and rheumatoid arthritis), this paper examines the relationship between the stresses of chronic illness and coping, and the ability of coping to explain psychological adjustment. Results show coping strategy use tends to be minimally explained by medical diagnosis. Cognitive strategies, including information seeking, are related to positive affect while emotional strategies, particularly those involving avoidance, blame and emotional ventilation, are related to negative affect, lowered self-esteem and poorer adjustment to illness. While the findings suggest that a stress and coping model may be valuable in understanding adjustment among the chronically ill, the general modesty of coping effects and the failure of the stress buffering hypothesis to explain adjustment indicates a need for new research approaches and some modification of current theories of coping. | |
| 182019 | Arthrographic diagnosis of synovial chondromatosis. | 1976 Aug | A case of synovial chondromatosis without plain film calcifications is presented. The arthrographic findings and differential diagnosis are discussed. | |
| 6959739 | Histological observation of the submandibular gland with special reference to the focal ly | 1982 Dec | Focal lymphocytic infiltration of the submandibular gland was investigated on the autopsy cases. The materials examined were 340 cases without the collagen diseases and 28 cases with collagen diseases. Of the 28 cases with collagen diseases, 20 were systemic lupus erythematosus, 2 with the coexistence of systemic, lupus erythematosus and Sjögren's syndrome, 4 with rheumatoid arthritis and 2 with progressive systemic sclerosis. Among the cases without the collagen diseases, the focal lymphocytic infiltration was seen in 154 cases (74%) of 209 males and in 94 cases (71%) of 131 females. All 28 cases with collagen diseases had a focal lymphocytic infiltration. The incidence of grade 3 or severe infiltration was 4% in the males and 14% in the females in the cases without the collagen diseases, 65% in the 20 cases with systemic lupus erythematosus, 50% in the 4 cases with rheumatoid arthritis and 50% in the 2 cases with progressive systemic sclerosis. No cases of very severe infiltration were found, which were seen in the classical Sjögren's syndrome, in both cases with and without the collagen diseases. Hyperplastic change in the ductal cells, which can be called an epimyoepithelial island, was found in 23% of the cases with collagen diseases. These observations suggest that the focal lymphocytic infiltrations is a focal sign of the immunologic disorder of the submandibular gland in the collagen disease. | |
| 326491 | Mefenamic acid: an under-rated antirheumatic? | 1977 | A double-blind crossover study was carried out in 18 patients with classical rheumatoid arthritis to assess the effectiveness of mefenamic acid (500 mg t.d.s.) compared with placebo or indomethacin (25 mg q.d.s.). Each treatment was given for 1 week and subjective and objective assessments were carried out at the end of each period. Results showed that both mefenamic acid and indomethacin were significantly better than placebo in most parameters. Although duration of morning stiffness and patient preference favoured indomethacin it was considered that there was no demonstrable difference of any clinical significance between the two active medications. | |
| 3860273 | Hypocholesterolaemia and abnormal high-density lipoprotein in rheumatoid arthritis. | 1985 Aug | Plasma lipid and lipoprotein patterns were determined in 54 female patients with rheumatoid arthritis (RA). The patients were divided into four groups, on the basis of the treatment that was being administered (gold, penicillamine, hydroxychloroquine and nonsteroidal anti-inflammatory drugs). Plasma cholesterol levels were significantly reduced in all groups. The reduced plasma cholesterol level was a result of 26% and 36% reductions in low- and high-density lipoproteins (LDL and HDL), respectively. Very-low-density lipoprotein cholesterol was reduced only in the group receiving hydroxychloroquine, and this was associated with decreased plasma triglycerides in this group. Plasma apolipoprotein (apo) B, the LDL protein moiety, demonstrated a pattern similar to that shown for LDL cholesterol. Plasma apo A-I, the major HDL protein, was, however, in the normal range, suggesting an abnormal HDL fraction. Even though reduced HDL cholesterol was found in RA patients, the HDL/LDL ratio was normal and the apo A-I/apo B ratio was increased, suggesting that these patients are not at increased risk for atherosclerosis. | |
| 162671 | A double-blind clinical trial to determine if an interaction exists between diclofenac sod | 1975 | A double-blind crossover trial between diclofenac sodium and placebo was carried out in 32 hospitalized patients who were thought to be stabilized on concurrent anticoagulant therapy with acenocoumarol. The object of the trial was to investigate any possible interaction between diclofenac and anticoagulant by monitoring prothrombin times daily through the four week period. No statistically significant difference between placebo and diclofenac could be shown and some problems of accurately monitoring prothrombin times are discussed. | |
| 350250 | Continued use of non-steroidal anti-inflammatory drugs: an index of clinical efficacy. | 1978 May | 1 A double-blind entry to a trial of an active non-steroidal anti-inflammatory drug, flurbiprofen against placebo was undertaken until 100 patients with classical rheumatoid arthritis had been allocated to each treatment. 2 Each patient was given a long-term supply of drug and was asked to vary their own dosage within simple limits, according to the severity of their symptoms. They were instructed to return immediately they felt dissatisfied with their medication either on account of side-effect or of lack of effect. 3 The length of time that patients remained satisfied with their drug was used as the sole measure of efficacy of the drug. At 2 weeks there were only 30% remaining on placebo and by 4 months no patients remained satisfied with the inactive drug. Forty-three per cent were satisfied with flurbiprofen at the end of 1 year. 4 Clearly compliance with anti-rheumatic drugs is better if the drugs are effective and there is no long-term placebo response in rheumatoid arthritis. | |
| 4082790 | [Initial results of the clinical use of the immunostimulant bestatin (3-amino-2-hydroxy-4- | 1985 Sep | We tested the efficacy of the immunomodulator Bestatin, which has been successfully applied in Japan, in a preliminary open study in ten patients with classical or definite rheumatoid arthritis. Patients whose arthritis was characterized by a low humoral activity showed a partial remission of the disease after six months' application of increasing doses of 10-60 mg in 48 hours. We found a significant increase in superoxide release from peripheral monocytes. Humoral parameters of inflammation such as erythrocyte sedimentation rate, C3a complement fraction, prostaglandin E2, and thromboxane B2 decreased. Concerning the subpopulations of lymphocytes we found a slight increase of activated T-lymphocytes and a decrease of O-cells and B-cells. The T-helper/T-suppressor ratio remained unchanged. The rheumatoid factor and the antinuclear antibodies showed no alteration under the treatment. Two weeks after withdrawal of Bestatin the improvement of the clinical and humoral parameter of the inflammation in rheumatoid arthritis vanished. No serious side effects were seen. Our results contribute to a long-term controlled study of the immunomodulator Bestatin as basic drug in the treatment of rheumatoid arthritis. | |
| 4089813 | Fibrinopeptide A in urine from patients with venous thromboembolism, disseminated intravas | 1985 Dec 17 | Urinary fibrinopeptide A immunoreactivity was determined by radioimmunoassay using two anti-fibrinopeptide A sera with a different specificity in patients with venous thromboembolism, disseminated intravascular coagulation and rheumatoid arthritis. Elevated levels were frequently observed with both sera, and intravenous administration of heparin in patients with a thromboembolic disorder resulted in a decline of urinary fibrinopeptide A (FPA) concentrations to normal or nearly normal values. For both sera significant correlations with plasma levels were found although one of the sera reacted significantly better with the material in urine samples from these patients than the other (p less than 0.0001, n = 73). Analysis of urinary fibrinopeptide A immunoreactivity by high performance liquid chromatography (HPLC) provided evidence that A peptide material present in this body fluid was heterogeneous. In view of the characteristics of the antisera used in this study, data suggest that urinary FPA immunoreactivity consists to a large extent of carboxyterminally degraded FPA. Excretion of circulating FPA immunoreactive material through the kidneys apparently involves dephosphorylation and carboxyterminal breakdown of the A peptide. Since both synthetic and native phosphorylated or unphosphorylated fibrinopeptide A appeared to be stable in urine in vitro, an active role of the kidney in degrading the A peptide is likely. | |
| 6692609 | The rheumatoid hand. Reflections on metacarpophalangeal arthroplasty. | 1984 Jan | Metacarpophalangeal (MP) implant arthroplasties have been widely used during the past 15 years. It is difficult to evaluate the effectiveness of MP arthroplasty. Patients with rheumatoid arthritis are so varied that meaningful comparisons of results from different series are not possible. However, certain factors influence the results of this operation. Some of these factors are related to the patient's motivation. Others include the condition of the adjacent joints and tendons. Staging of multiple procedures is advisable. The surgical technique is exacting. Postoperative therapy is vital in achieving maximum benefit from MP arthroplasties. Complications of this procedure include infection, prosthetic fracture, recurrent deformity, and limited motion. The concept of the flexible hinged prosthesis acting as a spacer to encourage encapsulation is good and is generally successful in improving hand function while correcting deformity and relieving pain. | |
| 92380 | Demonstration of two disease specific antigens in circulating immune complexes. | 1979 Sep | A method is described to assess antigenic cross-reactivity between soluble immune complexes precipitated from sera with polyethylene glycol. The precipitated complex from one serum was dissociated in acid and used to coat a plastic cup. Radioiodinated complexes from another serum were dissociated in the cup, neutralized and allowed to reassociate overnight. The binding of the labelled complex was used to measure the cross-reactivity between the complexes. Using this technique, complexes from a group of patients with haematuria and hypertension have been found to share an antigen, and a different antigen was found in patients with bullous pemphigoid. The participation of rheumatoid factors in the cross-reactions is unlikely, and no cross-reactivity of either group was found with sera from patients with rheumatoid arthritis. | |
| 473927 | [The value of morphology in the diagnosis of chronic polyarthritis]. | 1979 May | The clinician's question concerning the value of morphological findings in diagnosis of rheumatoid arthritis is answered by the pathologist. After a short discussion of clinical problems and the ARA-criteria, at first the diagnostic importance of synovial cytology in RA is dealt with. The patient's history, biopsy technique and methods are the most important prerequisites of an optimal assistance of the pathologist to a definite diagnosis; they are reviewed in short paragraphs. These data are the bases of the morphological evaluation which is discussed in detail. This is the most important part of the answer to questions of the clinician; the pathologist is not only able to verify the clinical diagnosis of rheumatoid synovitis or of RA but often he may decisively judge the course and activity of the disease and the therapeutic success. | |
| 6630947 | Implant arthroplasty in the rheumatoid hand and wrist: current state of the art in the Uni | 1983 Sep | Implant arthroplasty in deforming arthritis of the hand and wrist is a useful procedure that provides pain relief and mobility. Resection arthroplasty enhanced by silicone elastomer interpositional implants remains the standard of comparison and procedure of choice in most areas. Articulated and nonarticulated fixed-fulcrum implants have had limited success. Soft tissue disease significantly limits the eventual success of implant arthroplasty in the rheumatoid hand and wrist. | |
| 93146 | Extracellular aggregates of immunoglobulin in synovial fluid from rheumatoid arthritis. | 1979 Jul | Particulate extracellular aggregates of immunoglobulin can be demonstrated in many whole synovial fluids from patients with rheumatoid arthritis but not in other diseases. These occur only in seropositive patients and correlate with more active inflammation and lowered synovial fluid C3. Aggregates were associated with intracellular inclusions but were more abundant and always contained both IgG and IgM. No aggregates were seen in 50 control fluids. These aggregates are compatible with immune complexes and should be included in studies of immunologic events in rheumatoid fluids. |