Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 7440605 | Capitellocondylar total elbow arthroplasty. | 1980 Dec | Sixty-nine non-constrained capitellocondylar metal-to-plastic total elbow-replacement prostheses were implanted in sixty-four patients with rheumatoid arthritis. These patients were followed for an average of 3.5 years. Postoperative flexion and pronation were significantly improved, but no significant increase in postoperative extension or supination could be demonstrated. Based on a rating system evaluating pain and function, there were 87 per cent good or excellent results. The complication rate based on the total number of prostheses implanted was 39 per cent. Eight patients required revision of the arthroplasty: four for dislocation of the prosthesis, two for sepsis, one for loosening, and one for a fracture. Eight other asymptomatic patients showed minimum radiolucent lines adjacent to the ulnar component. No patient demonstrated radiolucent lines adjacent to the humeral component. | |
| 7071645 | Membranous nephropathy in rheumatoid arthritis. | 1982 Apr | We have described a man with classic rheumatoid arthritis who had membranous nephropathy associated with nephrotic syndrome not related to gold or penicillamine therapy. Complete remission of the nephrosis occurred after discontinuation of hydroxychloroquine therapy. Further study is needed to determine the incidence of subclinical membranous nephropathy in patients with rheumatoid arthritis, and the effect of drugs in triggering clinical manifestations of this condition. | |
| 6982041 | Rheumatic diseases other than rheumatic fever. | 1981 Jun | A total of 101 cases of rheumatic diseases collected during a period of six months from a hospital population have been analysed. These did not include rheumatic fever. Paediatric age group up to age of 12 years was not included in the series. Rheumatoid arthritis has been found to be the commonest condition, constituting 60 cases. Cervical spondylosis was next in common (24 cases). Ankylosing spondylitis and osteoarthritis constituted nine and six cases respectively. Emphasis has been laid on the bizarre manifestation of cervical spondylosis. The study, in spite of limitations throws some light on the relative frequency of rheumatic diseases other than rheumatic fever in Bangladesh. | |
| 7019872 | Immunologic tests of value in diagnosis. 1. Acute phase reactants and autoantibodies. | 1981 Aug | Acute phase reactants are nonspecific indicators of tissue necrosis and/or inflammation but may be helpful in determining activity of disease. Rheumatoid factor is likewise rather nonspecific, but its presence is helpful in predicting the course, severity, and complications of rheumatoid arthritis. Numerous antinuclear antibodies have been identified in collagen vascular diseases; perhaps the most specific association is between anti-Sm antibody and systemic lupus erythematosus. Anti-smooth-muscle and antimitochondrial antibodies can aid in differential diagnosis of liver disease, while antithyroid antibodies can perform a similar function in diffuse goiter. Anti-parietal-cell and anti-intrinsic-factor antibodies are quite specific for pernicious anemia. | |
| 7020060 | [Synovial vascularization and inflammation. II. Electron microscopy study of capillary per | 1981 Jun | The distribution of IgG and IgM into the normal and rheumatoid synovial membrane have been studied by the authors by means of immunoperoxidase electron-microscopy. Within the normal synovial while the IgG are diffusing out of the capillary the IgG are kept in the vascular lumen. Within the rheumatoid synovia IgG and IgM widely diffuse out of the microvasculature. This finding suggest that the rheumatoid inflammation is raising the permeability of synovial capillaries towards IgM molecules. | |
| 326260 | Bone marrow transplantation in patients with gold-induced marrow aplasia. | 1977 Jun | Aplastic anemia is a rare but usually fatal complication of gold salt therapy for rheumatoid arthritis. This report describes 3 patients who developed aplastic anemia while receiving gold salts, and a fourth patient who developed aplastic anemia after receiving gold and then cytotoxic agents. These patients failed to respond to conventional therapy for aplastic anemia and subsequently received bone marrow transplants from HLA-matched siblings. Engraftment occurred in all 4 patients. One patient is alive 2 years after transplantation, and 3 patients died of complications following transplantation. | |
| 7332378 | Serum calcium levels in rheumatoid arthritis. | 1981 Dec | Total and corrected (for albumin) serum calcium levels were investigated in a cross-sectional study of 394 patients with rheumatoid arthritis, 4490 healthy subjects, and 2609 inpatients at a district general hospital. Patients with rheumatoid arthritis had lower mean calcium levels than the healthy subject (p less than 0.001), but had similar levels to inpatients at the district general hospital. Thirty-eight inpatients with rheumatoid arthritis at a hospital for rheumatic diseases had lower mean corrected and total calcium levels than all other groups (p less than 0.01). Corrected or total calcium levels higher than 2.60 mmol/l or corrected calcium levels lower than 2.20 mmol/l were uncommon in the patients with rheumatoid arthritis. A longitudinal study of serum calcium levels in 17 patients with rheumatoid arthritis over 6-48 months showed considerable temporal variation in total and corrected calcium levels. Transient hypercalcaemia and hypocalcaemia occurred occasionally, but for most of the time calcium levels were normal. Changes in calcium levels were not related to changes in clinical, haematological, or immunological parameters of disease activity. Mean serum calcium levels are lower in disease than health; this occurs in RA as well as other diseases. | |
| 3898410 | Comparison of isoxicam and naproxen in patients with rheumatoid arthritis. A 4-week parall | 1985 Aug 17 | A 4-week parallel-group, double-blind study comparing isoxicam with naproxen was carried out in patients with rheumatoid arthritis. Both isoxicam and naproxen were found to be effective. In patients on isoxicam significant improvements in the articular index, grip strength, joint swelling, morning stiffness and the patients' overall clinical condition were observed: the results for naproxen were similar, but joint swelling did not improve. At the 2-week assessment naproxen produced significantly better results than isoxicam in terms of the articular index and the physician's assessment of the patients' condition, but this difference was not maintained at the 4-week assessment. This apparently more rapid onset of activity of naproxen is probably related to its shorter elimination half-life. No adverse experiences were reported during isoxicam treatment and this drug was better tolerated than naproxen. | |
| 4066892 | In what sense is rheumatoid arthritis the principal cause of death? A study of the Nationa | 1985 | Physicians' inadequacies in making out death certificates involving rheumatoid arthritis (RA) and the coders' reasons for not registering physicians' stated underlying cause as the underlying cause of death were investigated. The starting point of the study was a disagreement between physicians' reporting of RA on death certificates and the Swedish National Central Bureau of Statistics' (NCBS) registration of this condition, to the effect that the NCBS registered a 3.0-fold increase in mortality for women and a 2.7-fold increase for men attributed to RA between 1971 and 1975, whereas the physicians had reported practically no change at all for women and a slight decrease for men between the years. All Swedish RA death certificates for the years 1971 and 1975 were studied. A total of 1224 such certificates were identified. Four major qualifications for the coders to reject physicians' non-RA underlying cause, and for giving preference to RA in the registration of the underlying cause of death were discerned: RA appeared to have been favoured to the greatest extent by the NCBS (i) when RA was likely to have caused the reported underlying condition; (ii) when there is only one, non-RA, diagnosis reported in Part I of the certificate, and this diagnosis does not completely describe the train of events leading to death; (iii) when the diagnosis for the non-RA underlying condition provides less precise information about the site or nature of the underlying condition, compared with another diagnosis for another condition, RA, stated on the certificate; or (iv) when the reported non-RA underlying condition was unlikely itself to cause death, and was not reported as a cause of a more serious condition. The NCBS' increased registration of RA as the underlying cause of death between 1971 and 1975 could be explained neither by physicians' inadequacies in making out death certificates nor by a strict application of the international coding rules for registration of the underlying cause of death. | |
| 52975 | Sezary syndrome with arthropathy. Report of a case. | 1975 | A 65-year-old black female with Sezary syndrome had generalized intractable pruritus, erythroderma, alopecia, onychogryphosis, lumphadenopathy and hepatomegaly. Abnormal lymphocytes with large, convoluted and grooved nuclei (Sezary cells) were identified in the skin and peripheral blood. A striking feature of her disease was severe, deforming arthropathy of the hands and knees, a clinical finding which has been described previously in only one patient with Sezary syndrome. At necropsy no associated lymphoma was found. | |
| 1188392 | Wrist arthrography: review and comparison of normals, rheumatoid arthritis and gout patien | 1975 Nov | Bilateral wrist arthrograms performed on a randomly selected population of 100 adult males revealed an unexpected high prevalence of communications among the three wrist compartments. These findings warrant reassessment of wrist arthrographic criteris for synovial involvement of rheumatoid arthritis. Midcarpal joint extension correlated with increasing age and occupational trauma, suggesting a degenerative or "wear and tear" mechanism in the breakdown of the delicate interosseous intercarpal ligaments. Such extension was also found to a greater than expected frequency in gout. Radioulnar joint extension correlated with acute trauma secondary to wrist sprains or fractures, presumably through tears in the tough triangular fibrocartilage. Such extension was also found to a greater than expected frequency in RA. While midcarpal extension and inferior radioulnar extension correlate with gout and RA, respectively, their occurrence in a random adult male population is so frequent (as is three compartment communication) as to obviate their diagnostic value. However, synovial corrugation and lymphatic visualization were seen only in the wrists of patients with diagnosed inflammatory arthritic conditions and may have potential diagnostic significance. Selected anthropometric variables were analyzed by age in this randomly selected adult male population and compared with the gouty and RA patient groups. Significant continuously decreasing grip strength and hand mineralization occurred with age, which was opposite to the trend for osteoarthrosis. The hematocrit, erythrocyte sedimentation rate, and serum uric acid were impressively stable until the ninth or older decades, at which time a significant increase in sedimentation rate and decrease in hematocrit were found. | |
| 6251755 | Serum immunoreactive prolyl hydroxylase in inflammatory rheumatic diseases. | 1980 Jun | Serum immunoreactive prolyl hydroxylase protein (S-IRPH) was measured in 56 patients with inflammatory rheumatic diseases, and the values were compared with those in 32 control subjects. S-IRPH was above the 95% confidence limit of the controls in about 70% of the patients with active systemic lupus erythematosus, rheumatoid arthritis, scleroderma, Reiter's syndrome, Sjögren's syndrome, polyarteritis nodosa, or polymyositis. Raised values were observed in about half of the patients with an erythrocyte sedimentation rate (ESR) of 21-50 and in about 90% of those with ESR of over 50, whereas only about 10% of the patients with an inactive disease had an S-IRPH concentration exceeding this limit. Only 1 out of 8 patients with active ankylosing spondylitis had a raised S-IRPH value. The results support previous data indicating that significant changes in collagen metabolism occur in active connective tissue diseases. Assays of S-IRPH might be of some value in assessing the activity of these diseases and in monitoring the treatment provided. | |
| 314421 | Measles virus-specific antibodies and immunoglobulin M antiglobulin in sera from multiple | 1979 Jul | When rheumatoid factor in rheumatoid arthritis and multiple sclerosis sera was titrated by the fluorescent antibody method on measles virus-infected cells, there was a marked and variable drop in titer on acetone-fixed cells as compared with unfixed cells. This was accounted for by the failure of measles virus hemolysin-inhibiting (HLI) antibody of the immunoglobulin G class to bind to acetone-fixed infected cells. It was shown by staining unfixed and acetone-fixed measles virus-infected cells that rheumatoid factor in most rheumatoid arthritis sera combined with measles virus-specific hemagglutinin-inhibiting and HLI antibodies, whereas rheumatoid factor in multiple sclerosis sera combined only with HLI antibody. Rheumatoid factor of similar specificity was also observed in normal sera and occasionally in rheumatoid arthritis sera. Both rheumatoid arthritis and multiple sclerosis sera showed almost identical increases in average titer above normal of measles virus-specific fluorescent staining immunoglobulin G and HLI antibodies. | |
| 7394610 | D-penicillamine-induced bronchial spasm. | 1980 Jun | Although d-penicillamine has a wide range of benefits in many clinical conditions, various side effects have also been reported and preclude its further use in certain patients. In this case, d-penicillamine-induced reversible airway obstruction developed, despite the "go slow--go low" regimen as suggested to reduce the incidence of its side effects. The patient had bronchial spasm and angioedema shortly after the dose was increased from 500 mg to 750 mg/day. Persistent vigilance is necessary to avoid potentially fatal reactions. | |
| 6265553 | Discordant expression of 2 Epstein-Barr virus-associated antigens, EBNA and RANA, in man-r | 1981 Aug | The Epstein Barr nuclear antigen (EBNA) and the rheumatoid arthritis nuclear antigen (RANA) develop in human B lymphocytes that have been infected and transformed by Epstein Barr virus (EBV). Antibodies to RANA and EBNA are found only in individuals with prior exposure to EBV. The purpose of the present studies was to determine the relation of the 2 antigens to each other and to EBV genetic material, in human-rodent somatic cell hybrids. Cultured human B lymphoblastoid cells, Raji, Daudi, and RPMI 4098 were fused with thymidine kinase-deficient mouse or hamster fibroblasts. After selection and cloning in ouabain-HAT medium, the hybrid nature of the surviving cells was confirmed by isozyme analysis. The hybrid clones were analyzed for EBNA by anti-complement im,munofluorescence, and for RANA by anti-immunoglobulin immunofluorescence and immunodiffusion. The results showed that RANA and EBNA segregated entirely independently of each other in the hybrid clones. Two methods were used to detect the presence of EBV DNA sequences in the intracellular DNA of hybrid clones. The 1st method relied on the hybridization of labeled cRNA prepared from virion DNA with DNA from 8 hybrid clones affixed to nitrocellulose filters. The 2nd approach was to hybridize labeled intracellular DNA from 3 hybrid clones to Southern blots of cloned fragments of EBV DNA. These results suggested that the presence of EBV DNA was not sufficient for the expression of either antigen. One stable RANA-positive hybrid cell line contained at least 80% of the EBV genome in the absence of detectable EBNA. | |
| 6775078 | Efficacy and toxicity of retreatment with gold salts: a retrospective review of 25 cases. | 1980 Jul | We reviewed the records of 24 patients with rheumatoid arthritis who underwent 25 retreatments with gold salt injections given at a frequency greater than the usual monthly maintenance. Subject to the limitations of retrospective review, it was judged that every patient had improved on retreatment (5 fair, 19 good, 1 excellent), and there was only 1 instance of toxicity necessitating cessation of chrysotherapy. Repeat courses of gold salt injections of increased frequency appears to be a safe and effective therapeutic option for patients with rheumatoid arthritis who relapse after initial successful treatment. | |
| 138187 | [Toxic reactions to gold salts with severe enterocolitis in a patient with rheumatoid arth | 1976 Nov 13 | A case of severe enterocolitis which occurred on initiation of chrysotherapy for rheumatoid arthritis is reported. The patient, a male aged 50 years, suffered from dramatic diarrhea for several weeks. Biopsy specimens from the stomach, ileum and colon revealed signs of inflammation. Later, general toxicodermia, mouth ulcers, blood eosinophilia and asymptomatic proteinuria were observed. After several months all the side effects disappeared. The toxicodermia was the most persistent. | |
| 6692607 | Total elbow arthroplasty. | 1984 Jan | In the eight-year experience at the authors' institution (1974-1981) with an unlinked resurfacing elbow prosthesis, one failure occurred due to loosening of an ulnar component (1 of 153; 0.6%). The authors concluded that loosening of the prosthetic components in bone is not a serious problem, but other problems remain. Postoperative dislocation continued after a lateral approach was adopted but improved with the use of components of variable sizes. Ulnar nerve palsies are an unsolved problem and require special investigation in the rheumatoid patient. Other soft tissue problems have been relieved by the more physiologic lateral approach. Indications have been expanded to include posttraumatic or osteoarthritic conditions in relatively inactive elderly patients. | |
| 7389195 | Migration of blood and synovial fluid neutrophils obtained from patients with rheumatoid a | 1980 Jan | The unstimulated random migration and the serum-induced chemokinesis of neutrophils obtained from the peripheral blood of patients with rheumatoid arthritis (n = 19) was not different from those of controls (n = 20). However, neutrophils obtained from the joint fluid of rheumatoid patients (n = 10) demonstrated a reduced serum-induced chemokinesis which was correlated with the amount of immune complexes present in the synovial fluid. The chemotactic response of peripheral blood neutrophils from subjects with rheumatoid arthritis taking aspirin (n =11) was increased while that of those rheumatoid subjects not taking aspirin (n = 8) was the same as controls. It is concluded that although there is no impairment of the in vitro migratory capacities of peripheral blood neutrophils obtained from patients with rheumatoid arthritis, neutrophils obtained from synovial fluids exhibit a marked defect in chemokinesis which may be related to the ingestion of immune complexes within the joint space. | |
| 60109 | Mononuclear cells in human synovial fluid. Identification of lymphoblasts in rheumatoid ar | 1976 Jul | A simple method was developed to identify large mononuclear (LMN) cells in human synovial fluid based on morphology and staining with Sudan black B. All cells were classified as monocyte-derived macrophages (MDM), lymphoblasts (LB), or synovial lining cells (SLC). Lymphoblasts were seen in 58 of 60 rheumatoid fluids (mean: 69 +/- 18% LB per LMN cells). However lymphoblasts were rarely seen in synovial fluids from patients with crystal-induced synovitis or bacterial infections. |