Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 6651371 | Serum amyloid-A protein concentration in rheumatoid arthritis and its role in monitoring d | 1983 Dec | The serum concentrations of serum amyloid-A protein (SAA), C-reactive protein (CRP), and alpha 1-acid glycoprotein (alpha 1-AGP) have been measured in 185 patients with rheumatoid arthritis. SAA and CRP concentrations correlated well (r = 0.86) both within and above the normal ranges, though SAA showed a greater incremental increase than CRP. All patients with normal SAA levels also had normal CRP and alpha 1-AGP concentrations. In contrast, in 40% of patients with normal CRP and alpha 1-AGP concentrations the SAA was raised, sometimes markedly so. The clinical and serological assessments of disease activity in these patients were not significantly different from those with concomitantly raised levels of CRP. These findings suggest that SAA is a more sensitive marker of inflammation than is CRP. The role of the measurement of SAA as a monitor for inflammatory disease activity is discussed. | |
| 6348967 | Clinical evaluation of choline magnesium trisalicylate in rheumatoid arthritis. | 1983 Aug 6 | Twenty-three patients with rheumatoid arthritis were given choline magnesium trisalicylate (CMT) (Trilisate; Adcock-Ingram) in a dose of 1.5 g (3 tablets) twice daily and were followed up for 6 weeks. Nineteen patients completed the study and the data obtianed were subjected to statistical analysis. There was a statistically significant improvement in the indices of inflammation. Seven patients developed tinnitus, which resolved on reduction of the dose to 1 g (2 tablets) twice daily. Four patients developed pruritus and minor gastro-intestinal side-effects were present in 3 patients, but all these side-effects were transient and no change in therapy was necessary. | |
| 7455634 | Anaerobic bacterial coxitis and pseudocystic tumour in rheumatoid arthritis. A case report | 1980 | When patients with rheumatoid arthritis develop rapidly growing tumours around the hip or elbow joint, the possibility should be considered that this condition could be pseudocystic with a low virulent infection. The present report describes such a case of anaerobic bacterial coxitis with rapidly growing tumour. | |
| 6860373 | Gold therapy in the elderly rheumatoid arthritis patient. | 1983 Jun | Forty elderly (greater than or equal to 60 years old) and 101 young (less than 60 years old) rheumatoid arthritis patients receiving injectable gold therapy were followed prospectively between April 1971 and April 1982. The mean total gold compound received was 1,392 mg in the young group and 1,861 in the elderly group. Besides age, the only significant difference between the two groups was the increased gold compound received by the elderly. To determine efficacy and toxicity within and between certain age groups, the 141 patients were divided into 4 arbitrary age groups: group A (less than 30 years), group B (30-44 years), group C (45-59 years), and group D (greater than or equal to 60 years). The elderly responded to the gold therapy as well as the young patients did, at any time frame examined after 3 months of therapy. There was no difference in clinical benefit among groups A, B, C, and D. Nine patients in the elderly group and 15 in the young group had therapy discontinued because of no response. This difference was not significant among the groups A, B, C, and D. There was no difference in outcome of individual toxicity between the elderly and the young groups, and no difference in frequency of toxicity between the age groups A, B, C, and D. Serious hematologic toxicity occurred only in patients over 47 years of age, and nephrotic syndrome occurred only in patients over 52. In this study, gold therapy was found to be as clinically beneficial in the elderly as in the young patients, and the toxicity and drug failure rates were not significantly different. | |
| 271289 | Sialochemistry of patients with rheumatoid arthritis. Electrolytes, protein, and salivary | 1978 Jan | Sialochemistry was undertaken to detect subclinical involvement of salivary glands in patients with rheumatoid arthritis (RA). The concentrations of salivary sodium and IgA were significantly elevated in 24 percent of the RA patients. Eighty per cent of the patients with elevated sodium and IgA concentrations had keratoconjunctivitis sicca as well. No correlation between serum and salivary IgA levels was found. The results indicate that salivary sodium and IgA levels can be used for detection of subclinical salivary gland involvement and for follow-up of RA patients. | |
| 6442054 | [Indications and contraindications for systemic gold therapy]. | 1984 | At the current state of the art a comparison of gold salts and other therapeutic modalities in terms of their risk-benefit ratios clearly shows chrysotherapy to have a place in the treatment of active rheumatoid arthritis. Factors supporting the use of gold salts as base-line drugs for active rheumatoid arthritis include the extensive experience accumulated with chrysotherapy as a basic antirheumatoid treatment and the potential of gold salts to halt joint destruction. The application of gold salts in the treatment of juvenile chronic polyarthritis and psoriatic arthritis rests on the same rationale. Further studies are needed to establish the place of gold salts in ankylosing spondylitis and chronic Reiter's syndrome. Contraindications include diseases of organs likely to be the site of disastrous side effects on gold administration as well as disseminated lupus erythematosus and arthritis in the presence of colitis. Experiences with systemic gold therapy will, no doubt, be expanded in many a respect by the availability of an oral dosage form. Whatever the indication of gold salts a thorough understanding of clinical rheumatology, a complete mastery of the technique and consistent, meticulous patient monitoring are paramount if treatment is to be beneficial. | |
| 6577907 | HLA-A, B and DR antigens and properdin factor B allotypes in Caplan's syndrome. | 1983 Jul | Seventy-nine cases of Caplan's lung were typed for HLA-A and B antigens. The antigen Bw45 was present only in those patients with rheumatoid factor and was of significantly higher frequency (13.6%) when compared to a non-coal dust exposed population of 316 (1.0%). Those patients without rheumatoid factor showed an increase in HLA-A1 and B8 (58.6% and 51.7% respectively) when compared to the rheumatoid factor positive group (29.6% and 25.0% respectively). Clinical and radiological reassessment were performed on 49 of these patients who were also typed for HLA-DR antigens and properdin factor B allotypes. HLA-DR4 was raised in the rheumatoid factor positive group with rheumatoid arthritis (55.2% compared to 25.8% in the non-coal dust exposed group and 37.3% in coalworkers with normal radiographs). The HLA-DR results are comparable to those found in other studies of rheumatoid arthritis not associated with pneumoconiosis. The findings for HLA-A1, B8 and DR4, however, were not significant after correction was made for the number of antigens tested for. No particular Bf allotype was found to be associated with either the lung change or the arthritis. The induction of the pulmonary lesion in Caplan's syndrome is discussed in relation to the HLA findings. | |
| 3990944 | Computed tomographic myelography (CTM) in atlanto-axial rheumatoid arthritis. | 1985 | Thirty-two patients with severe cervical rheumatoid arthritis were investigated preoperatively with cervical myelography (CeM) and computed tomographic myelography (CTM). The severity of their clinical symptoms correlated excellently with a combination of the deformation of the spinal cord at the atlanto-axial level, the lateral dislocation of the cord at the same level, and the deformation of the cord at some lower cervical level. Obstructing soft-tissue excrescences seemed to have little significance. No correlation was found in this study between the deformation of the cord and the main findings of the plain films: the atlanto-axial subluxation (AAS), the vertical subluxation (VS), or their combination. | |
| 6602882 | HLA-DR antigens in Blacks with rheumatoid arthritis and systemic lupus erythematosus. | 1983 Apr | HLA-DR locus antigens were studied in a large population of Black Americans with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). An association was found with DR4 in RA (p less than 0.001) and DR3 in SLE (p less than 0.01). Our findings are similar to those reported in Caucasians. No significant correlations between clinical manifestations and DR locus antigens were apparent in either disease. Our results support the association of D locus antigens with disease susceptibility more than with clinical severity. | |
| 7368979 | Penicillamine treatment in rheumatoid arthritis. A retrospective study. | 1980 | Out of 64 patients with rheumatoid arthritis (RA), 42 were treated with D-penicillamine (D-Pa) for more than 6 months and 22 for less than 6 months. The latter patients were excluded from the evaluation of the effect. The former patients were treated with doses of 600-1 250 mg daily for 6-41 months (mean 16.8). The clinical effect was retrospectively assessed as favourable in 24 patients, 12 did not respond and the effect could not be assessed in 6. The clinical assessment was supported by significant reductions of ESR and orosomucoid. Adverse reactions, although rarely serious, led to withdrawal of the drug in 25 (39%) of the 64 patients. It is concluded that D-Pa is a valuable drug in the treatment of severe RA. | |
| 967164 | Characteristics of driving in relation to the drug and alcohol use of Finnish outpatients. | 1976 | A questionnaire was administered to 765 rheumatoid arthritic, 715 tubercular and 1,050 psychiatric outpatients and to 587 control subjects concerning their use of drugs and alcohol, driving habits and traffic accident involvement. The driving populations of all groups were matched as to their age and area of residence. The results of the study show a relatively very small number of driving licence holders among rheumatoid and psychiatric patients whereas the tubercular group includes as many driving licences as the control group. Also, the annual driving experience of the rheumatoid arthritic and psychiatric patients was low. The main reason for driving was recreation, and the driving mainly took place on highways. Excluding the psychiatric patients, the patient groups had been involved less often in traffic accidents that the controls. The use of drugs correlated inversely with driving: the more you used drugs the less you drove. Also the consumption of alcohol increased in direct proportion to the number of kilometres driven: the greater the alcohol consumption per drinking session, the more you drove annually and were involved in accidents. | |
| 171408 | Predominance of synovial fluid lymphocytes in early rheumatoid arthritis. | 1975 Sep | Evaluation of 158 synovial fluids, mainly from patients with rheumatoid arthritis (RA) and the crystal deposition fiseases (CDD), revealed differences in the differential white blood count and numbers of cytoplasmic inclusion bodies (CIB) present. Lymphocytes and CIB were increased in RA, suggesting a different pathologic mechanism from that of CDD. Lymphocyte-like cells contained CIB implying phagocytic capability. Lymphocytes were the initial predominant cell type in RA of less than six weeks disease duration. Later polymorphonuclear leukocytes increased, possibily representing a secondary non-specific inflammatory response similar to that seen in CDD. | |
| 115258 | Prostaglandins, rheumatoid arthritis, fibrin and lymphoedema. | 1979 | Rheumatoid joint swelling is in part due to lymphoedema accompanying extravascular (E-V) deposition of fibrin. Non-steroidal anti-inflammatory drugs (NSAIDs) such as aspirin (ASA), phenylbutazone (PBZ) and indomethacin (INDO) which share the ability to inhibit prostaglandin synthetase fail to prevent fibrinous lymphoedema occurring in rabbit skin homografts in association with the presence of sensitised lymphocytes. The data highlight the need to define whether or not prostaglandins promote lymphocytic fibrinous lymphoedema. | |
| 1277880 | An ophthalmic study of ibuprofen in rheumatoid conditions. | 1976 | A total of 247 patients suffering from rheumatoid arthritis and allied conditions were referred for routine ophthalmological examination with particular reference to ocular rheumatoid involvement. Of these, 197 were already receiving ibuprofen before their first assessment while 50 had a baseline assessment before commencement of ibrupofen therapy. All patients were examined on at least two occasions. No macular lesions were discovered which could be directly attributed to ibuprofen therapy. | |
| 6600299 | The manubriosternal joint in rheumatoid disease. | 1983 Jan | Manubriosternal joint abnormalities are often undetected causes of chest pain. Twenty-five normal patients and 40 cadaver specimens were evaluated to establish the normal radiographic anatomy of this articulation. Analysis of the manubriosternal joint was carried out in rheumatoid diseases in order to ascertain the incidence and variety of abnormalities. Twenty-seven of 100 manubriosternal joints were abnormal in rheumatoid arthritis. Of 25 patients with ankylosing spondylitis 20 (80%) revealed abnormalities either with erosions or fusion. None of 25 patients with psoriatic arthritis and none of 20 with Reiter syndrome showed erosions or ankylosis. The articulation should be evaluated in rheumatoid diseases and in non-arthritic patients with chest and/or shoulder pain. | |
| 7328571 | Rheumatoid subcutaneous bursitis. | 1981 Nov | We reviewed 11 patients with rheumatoid subcutaneous bursitis involving the olecranon bursa in 10 and an adventitious bursa in 1. All patients had a positive latex fixation test for rheumatoid factors. The mean bursal fluid white blood count (WBC) was 2,924/mm3 compared with a mean joint fluid WBC of 15,608/mm3 in 32 consecutive cases of classical or definite rheumatoid arthritis (p less than 0.001). Bursal fluid glucose and complement concentrations were low. Cholesterol crystals were present in 5 of 6 nodular bursae, and in none of the 5 non-nodular bursae (p less than 0.05). Two patients had acicular cholesterol crystals that had previously led to an erroneous diagnosis of gout. | |
| 7178855 | Circulating immune complexes in healthy persons. | 1982 | The prevalence of circulating immune complexes (CIC) and C4 and C3 activation products (C4 and C3 A.P.) was investigated in sera from 106 blood donors, 100 hospital staff-members, 63 patients with rheumatoid arthritis and active synovitis, and in 25 hospital staff-members who had monthly tests performed during one year. CIC were detected by means of a complement consumption test and a polyethylene glycol precipitation test. C4 and C3 A.P. were demonstrated by means of crossed immunoelectrophoresis. No significant differences in the prevalence of CIC were found between blood donors and hospital staff-members (3 and 9%, respectively) and no age and sex differences were observed. In the longitudinal study of hospital staff-members, a significantly increased incidence of CIC was found during the winter months. CIC were found in 86% of the patients with rheumatoid arthritis. C4 and C3 A.P. were found significantly more often in sera with than without CIC. The significance of CIC detection may be increased by the simultaneous demonstration of C4 and C3 A.P. and by making allowance for seasonal variations. | |
| 7446039 | Migration of the acetabular socket after total hip replacement determined by roentgen ster | 1980 Jun | In order to evaluate the feasibility of a roentgen stereophotogrammetric method for the analysis of the migration pattern of joint prostheses, tantalum balls were implanted into the acetabular socket and the pelvic bone during total hip replacement in four patients with rheumatoid arthritis. During the postoperative period, the migration of the acetabular socket was determined. The observation period varied from 5-24 months. No clinical or radiographic signs of mechanical loosening or infection were noted. All the investigated patients showed a gradual migration of the acetabular socket. The cranial migration measured up to 1.8 mm in 2 years. The migration along the transverse and sagittal axes was less but not constantly directed. The rotatory movements about the three axes varied and measured up to 5.5 degrees in 2 years. The translation and rotation were greatest during the first few months. The results indicate a gradual migration of the acetabular socket in hip arthroplasty in the osteopenic skeleton in rheumatoid arthritis. IN CONCLUSION: roentgen stereophotogrammetry may prove to be a valuable means of analysing the migration of implanted prostheses and detecting prosthetic loosening, thereby increasing the possibility of early and correct diagnosis and therapy. | |
| 3927174 | Association of rheumatoid arthritis and primary osteoarthritis with changes in the glycosy | 1985 Aug 1 | Rheumatoid arthritis (RA) is a widely prevalent (1-3%) chronic systemic disease thought to have an autoimmune component; both humoral and cellular mechanisms have been implicated. Primary osteoarthritis (OA) is considered to be distinct from rheumatoid arthritis, and here damage is thought to be secondary to cartilage degeneration. In rheumatoid arthritis, immune complexes are present that consist exclusively of immunoglobulin, implying that this is both the 'antibody' (rheumatoid factor [RF]) and the 'antigen' (most commonly IgG). Autoantigenic reactivity has been localized to the constant-region (C gamma 2) domains of IgG. There is no evidence for a polypeptide determinant but carbohydrate changes have been reported. We have therefore conducted a study, simultaneously in Oxford and Tokyo, to compare in detail the N-glycosylation pattern of serum IgG (Fig. 1) isolated from normal individuals and from patients with either primary osteoarthritis or rheumatoid arthritis. The results, which required an evaluation of the primary sequences of approximately 1,400 oligosaccharides from 46 IgG samples, indicate that: (1) IgG isolated from normal individuals, patients with RA and patients with OA contains different distributions of asparagine-linked bi-antennary complex-type oligosaccharide structures, (2) in neither disease is the IgG associated with novel oligosaccharide structures, but the observed differences are due to changes in the relative extent of galactosylation compared with normal individuals. This change results in a 'shift' in the population of IgG molecules towards those carrying complex oligosaccharides, one or both of whose arms terminate in N-acetylglucosamine. These two arthritides may therefore be glycosylation diseases, reflecting changes in the intracellular processing, or post-secretory degradation of N-linked oligosaccharides. | |
| 6207591 | Characterization of plasma membranes and rough endoplasmic reticulum of synovial cells cul | 1984 | [35S]methionine-labelled plasma membrane (PM) and rough endoplasmic reticulum (RER) proteins were analysed from synovial cell cultures derived from rheumatoid arthritis (RA) and reference patients. Pure RER was prepared by a modification of CsCl-containing sucrose-cushion method. The PM proteins were resolved into 30-35 bands using sodium dodecyl sulphate-electrophoresis in polyacrylamide gradient gels. The major polypeptides had apparent molecular masses of 170, 140, 110, 60, 40, 33, 23 and 14 kilodaltons. The major RER polypeptides had the apparent molecular masses of 170, 74, 58 and 35 kD. No reproducible differences were demonstrated in the polypeptide patterns or in the specific activities of the PM and ER (endoplasmic reticulum) marker enzymes between cells from RA and reference patients. The results reflect similarities of membrane structures in RA and reference cells, although differences have been reported in their metabolism. |