Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 3843140 | Overlap syndromes with sarcoidosis. | 1985 Sep | It is hoped that readers of this article will make a note of any other disorders which occur in their patients with sarcoidosis. We shall welcome this list and the frequency with which other disorders coincide with sarcoidosis. | |
| 6420652 | Gold compounds in rheumatic diseases--1. | 1984 Jan 21 | Gold complexes diminish synovitis and improve therapeutic outcome in rheumatoid arthritis, psoriatic arthritis, some forms of juvenile chronic arthritis, and palindromic rheumatism. The decision to treat a patient with a gold compound should not be undertaken lightly. It should be understood by the patient that the commitment to therapy is potentially long-term, that major benefit is not assured, and that there is, approximately, a 50% probability of an adverse reaction which may terminate treatment. Nevertheless, most adverse effects are mild and transient and the probability of good control, even remission, in an otherwise threatening disease, is sufficiently high to justify a therapeutic trial in the majority of patients. Those patients whose rheumatoid arthritis appears to respond to gold may be encouraged to continue long-term therapy with maintenance doses, in view of the evidence of sustained efficacy in most patients and of the declining risk of adverse reactions after the first 12 months. | |
| 4042482 | Bilateral total knee arthroplasties. Comparison of simultaneous (two-team), sequential, an | 1985 Oct | Simultaneous and sequential operations for bilateral total knee arthroplasties (TKA) for arthritis were examined for determination of the relative safety of each method. The postoperative morbidity was analyzed in three groups of patients who were similar with respect to age, sex, type of arthritis, preoperative range of motion, and postoperative management. Group I (22 patients) had both knees replaced simultaneously under one anesthesia. Group II (26 patients) had two operations staged about 17 days apart during a single hospitalization. Group III (20 patients) had TKA in two hospitalizations with the operations separated by about eight months. In this small series of cases there were fewer complications and a significantly shorter hospitalization in the group having simultaneous bilateral TKA. | |
| 1153765 | Insufficiency and stress fractures of the long bones occurring in patients with rheumatoid | 1975 Sep | The occurrence of stress and insufficiency fractures in patients with long-standing rheumatoid arthritis has not been sufficiently emphasized. Osteoporosis due to rheumatoid arthritis and corticosteroid therapy, joint stiffness, contracture, and angular deformity of the extremity, and the unaccustomed exercise after reconstructive joint surgery combine to predispose to the occurrence of these fractures in these patients. The pain and disability caused by these fracture is often attributed to rheumatoid joint involvement. The fracture may not be visible on radiographs obtained near the onset of symptoms, and serial examinations may be needed for diagnosis. | |
| 598119 | Excision of the cruciate ligaments in total knee replacement. | 1977 Jul | The cruciate ligaments (and the intercondylar eminence of the tibia) should be removed when the knee is replaced. A mechanically unlinked prosthesis can be designed which will then be capable of restoring "cruciate" stability, i.e., anteroposterior stability of the tibia in the flexed knee. A knee replaced with such a prosthesis will only be stable if the prosthesis is inserted using the correct instruments and technique. Stability depends as much on precise surgical technique as it does on prosthetic design. | |
| 3986006 | Phagocytosis and intracellular killing by polymorphonuclear cells from patients with rheum | 1985 Apr | The present in vitro study concerned the phagocytosis and intracellular killing by polymorphonuclear cells (PMN) of 5 patients with rheumatoid arthritis (RA) and 12 patients with Felty's syndrome (FS). PMN phagocytosis was assessed by microbiologic and morphologic methods, and intracellular killing was measured independently of continuous phagocytosis of viable bacteria (Staphylococcus aureus). PMN from patients with RA or FS ingested S aureus opsonized with immunoglobulins and complement as effectively as did PMN from healthy donors. However, the capacity of patient PMN to ingest S aureus opsonized with sera lacking complement activity, e.g., heat-inactivated donor serum and the sera of 2 patients with FS, was lower than that of healthy donor PMN. This decreased ingestion is associated with diminished expression of Fc receptors on the membrane of PMN from patients who have RA or FS. As with sera lacking complement activity, decreased capacity to ingest S aureus was observed after preloading donor PMN with immune aggregates, which also decreased the expression of Fc receptors. PMN from patients with RA or FS were found to be as active in killing S aureus as cells from healthy donors. | |
| 352601 | Changes in the collagen of synovial membrane in rheumatoid arthritis and effect of D-penic | 1978 Jul | 1. Normal synovial membrane contains approximately equal proportions of two genetically distinct forms of collagen, types I and III. The proportion of these two collagens is unchanged in rheumatoid synovium but in addition a small amount of basement membrane collagen is present. Tissue culture of rheumatoid synovium confirms the synthesis of both type I and III collagens. 2. In young normal synovium both type I and type III collagens are stabilized by a reducible keto cross-link, which is replaced in adult tissue by an as yet unknown non-reducible cross-link. During the proliferation of the collagen in adult rheumatoid synovium a high proportion of the keto cross-link is present. This cross-link is not susceptible to cleavage by D-penicillamine, nor does the drug have any effect on the rate of synthesis in vitro. The mode of action of D-penicillamine in rheumatoid arthritis does not appear to involve a direct effect on the synovial membrane collagen. | |
| 6379072 | [Leukocyte migration inhibitory factor of synovial fluid lymphocytes in rheumatoid arthrit | 1984 Jan | Synovial fluid lymphocytes from patients with rheumatoid arthritis were examined for the presence of leukocyte migration inhibitory factor by the agarose technique of Clausen. T and B lymphocytes were stimulated with phytohemagglutinin, concanavalin A, and pokeweed mitogen, and the culture supernatants were used for the migration inhibitory test. Migration index of the culture supernatants of T cells from rheumatoid synovial fluids was significantly greater than those of peripheral blood from rheumatoid patients and healthy controls. The results indicated that the production of leukocyte migration inhibitory factor following stimulation by mitogens was decreased in the T cells of rheumatoid synovial fluid. In the rheumatoid synovial fluid there was a positive correlation between the migration index and polymorphonuclear leukocyte counts. A similar result was also obtained in the study of B cells from rheumatoid synovial fluid. These results suggest that the rheumatoid synovial lymphocytes have been already activated in the synovial fluid. On the other hand, the supernatants of rheumatoid synovial fluid showed an elevated migration index, exceeded 1.0 and higher than those of osteoarthritic synovial fluid. This suggests that chemotactic factors play an important part in the rheumatoid synovial fluid, though the leukocyte migration inhibitory factor is present in the rheumatoid fluid. | |
| 6862524 | The successful use of asialylated IgG as an immunogen and arthritogen in the rabbit. | 1983 Jul | Joint lesions, closely resembling the main features of those seen in rheumatoid patients, were produced by intra-articular injections of asialylated homologous IgG into presensitized rabbits. The inflammatory changes were characterized by areas of extremely dense chronic inflammatory cell infiltration, where the lymphocytes were often aggregated into lymphoid follicles. There were also signs of involvement of the contralateral, saline-injected knee. Formation of an experimental rheumatoid factor-like antibody, detected by its ability to agglutinate sheep erythrocytes sensitized with baboon IgG, was also demonstrated. In addition, the rabbits developed other manifestations associated with rheumatoid arthritis, namely increases in erythrocyte sedimentation rate, serum haptoglobin concentration and joint size. | |
| 76667 | Effect of corticosteroids on the human immune response: comparison of one and three daily | 1978 Apr | In spite of the increasing use of single and multiple pharmacologic intravenous pulses of MPS for immunosuppression in various diseases, their immunosuppressive effects have not been documented. We treated two groups of six patients with classic RA unresponsive to conventional therapy with either one or three daily 1 gm intravenous doses of MPS and measured the immune response and clinical activity over 16 weeks. Lymphocytopenia with selective T lymphocyte suppression was noted 2 hr following each infusion, which was maximal at 6 hr with complete recovery 24 hr after each dose beyond which no lymphocytopenia or T lymphocyte depletion was seen. Preservation of skin test positivity to recall antigens such as PPD and histoplasmin, rise in antibody titers to the secondary antigens tetanus and typhoid, and primary antibody response to KLH were found in both groups after treatment. Serum gamma globulin concentrations were unchanged. Five of six patients receiving 3 doses and three of six receiving 1 dose had satisfactory improvement in clinical parameters, with maximal benefit seen within the first 4 days. Six patients still felt better at 4 weeks, and one patient in each group entered a clinical remission greater than 16 weeks. We conclude that higher and repeated doses of MPS caused neither greater lymphocytopenia nor more prolonged suppression of recirculating lymphocytes than the conventional oral doses. The clinical benefits stem from reduction of inflammation, and it is doubtful that pulse therapy by itself induced significant generalized immunosuppression. | |
| 914088 | Hand assessment--a realistic reappraisal. | 1977 Jun | In order to evaluate surgical procedures practised on the rheumatoid hand, assessment of hand function, both before and after surgery, must be made on a practical basis rather than a mathematical one. | |
| 6715030 | Manganese-containing superoxide-dismutase deficiency in polymorphonuclear leukocytes of ad | 1984 Mar | Superoxide dismutase (SOD) is known to regulate the level of superoxide radicals inside cells. The purpose of this work was to investigate the role of SOD activity in tissue damage produced by superoxide radicals. SOD was measured in polymorphonuclear cells of patients with rheumatoid arthritis and controls. The distinct SOD activities, including manganese-containing and copper-zinc-containing enzymes, were evaluated in cytoplasma and mitochondria of human granulocytes. Except for the comparison between total SOD and cytoplasmic copper-zinc SOD, no correlation was found among the different SOD levels. Moreover, a significant decrease was observed only for cytoplasmic manganese-containing enzyme in granulocytes of adults with rheumatoid arthritis. These data confirm the necessity of evaluation of various SOD classes and suggest the interest of biochemical tests in granulocytes for early diagnosis and better comprehension of tissue damage due to inflammation. | |
| 6166255 | Antiperinuclear factor and keratin antibodies in rheumatoid arthritis. | 1981 Jun | Tests for antiperinuclear factor (APF) demonstrable by indirect immunofluorescence (IF) on smears of human buccal mucosal cells and for antibodies to keratin (AKA) detected on cryostat sections of rat oesophagus were performed on serum from 102 cases of rheumatoid arthritis (RA) and 117 controls. APF was detected in 92% of the cases of RA; positive tests obtained with non-RA sera were generally weaker than those given by the RA group, and the antibody in both RA and non-RA serum was predominantly IgG class. The difficulty in obtaining suitable substrate material previously reported was confirmed, and only 2 satisfactory donors were identified among 27 individuals tested. The incidence of keratin antibodies detected was found to be related to the site from which the tissue was taken; low oesophagus provided the best discrimination between RA and controls (51% and 5% positive respectively), and cardia of the stomach gave the highest incidence of staining in all groups. A laminar staining pattern was seen with most positive sera, but occasionally the keratinised layer was diffusely stained. The presence of AKA showed a marked correlation with both IgM rheumatoid factor and increased Clq binding in RA, but APF did not. | |
| 7044800 | Crossover comparison of benoxaprofen and indomethacin in rheumatoid arthritis and osteoart | 1982 | The safety and efficacy of benoxaprofen (300 or 600 mg) and indomethacin 75 to 150 mg) were compared in optimum dosage levels for 91 patients with rheumatoid arthritis or osteoarthritis. These multicenter studies were conducted by eight investigators. Overall, the two drugs brought significant and similar improvements in both indications. Benoxaprofen responses were significantly better for several rheumatoid arthritis efficacy measurements, while indomethacin exhibited better responses in some osteoarthritis parameters. Adverse effects were similar for both drugs but fewer drug-related side effects were observed with benoxaprofen. Mild to moderate gastrointestinal complaints were reported with both drugs. In the rheumatoid arthritis study, onycholysis appeared in three patients taking indomethacin although two had received benoxaprofen as first therapy. Unfavorable trends in some laboratory values occurred in nearly twice as many patients on indomethacin. These results were obtained with once-daily benoxaprofen dosage compared to three-times-daily administration of indomethacin at total daily doses titrated to the individual patients. | |
| 6176192 | Frequency of occurrence, mode of development, and significance or rice bodies in rheumatoi | 1982 Apr | The incidence of rice bodies (RB) in synovial effusions has been studied in 36 patients with rheumatoid arthritis (RA) and in 12 patients with seronegative inflammatory arthritis (7 cases of Still's disease, 3 of psoriatic arthritis, and 2 of ankylosing spondylitis). In the RA group 50 joints were aspirated before and after saline lavage with a specially designed wide-bore needle. RB were found in 72% overall of the joints studied in this group, 14% on initial simple aspiration and an additional 58% after lavage. In contrast no rice bodies were found in 31 aspirations with lavage by an identical technique in the 12 patients with seronegative synovitis. The RB in RA synovitis occurred both early and late in the course of the disease and were not related to the severity of clinical or radiological changes. However, removal of rice bodies was accompanied by clinical improvement and reduction of synovitis. Macroscopically RB varied in shape and size, some being so large as to preclude effective removal by needles of the gauge customarily employed for joint aspirations. Microscopically the majority of RB were composed of coarsely reticular material reacting immunologically with antifibrinogen and antifibronectin and containing mononuclear cells. Some showed vacuolation suggestive of fibrinolysis, but many showed organisation like that seen in established connective tissues, with the formation of mature collagen, reticulin, and elastin. These findings are discussed in relation to the origin, development, and significance of rice bodies in rheumatoid synovitis. | |
| 6452523 | Suppressor T cell dysfunction and anti-suppressor cell antibody in active early rheumatoid | 1981 Jan | Suppressor T cell hypofunction was found in active early rheumatoid arthritis (RA) (disease less than 3 months) and not in active late RA (greater than 6 months) or inactive RA. Active early RA patients when they were restudied 11-23 months later had normal suppressor cell function despite persistence of disease activity. Anti-suppressor cell antibody of the IgG class could be detected in plasma from active early RA patients and not in plasma from the other RA groups or the non RA controls. B cell targets for the Concanavalin A activated suppressor T cells were found to be functionally normal in early active RA. Suppressor cell hypofunction may contribute to the initiation, but not the persistence of rheumatoid synovitis. | |
| 6896428 | Comparison of serum 1,25-dihydroxycholecalciferol concentrations in rheumatoid arthritis a | 1982 Jun | We have previously compared 25-hydroxycholecalciferol levels in the serum of patients with osteoarthrosis and rheumatoid arthritis, finding no significant difference between the circulating levels of this hormone. We have now estimated 1,25-dihydroxycholecalciferol levels on stored sera from the same groups of patients and found no significant difference in the levels of this hormone between the 2 groups. The osteopenia that distinguishes rheumatoid arthritis from osteoarthrosis is not the result of altered levels of systemic 25OHD3 or of 1,25(OH)2D3. Local factors may be more important in its pathogenesis. | |
| 6725697 | Computed tomography of the hindfoot. | 1984 Jun | This investigation used computed tomography (CT) to study the normal anatomy of the hindfoot and to demonstrate abnormalities in patients with rheumatoid arthritis, pes planovalgus , old trauma, and soft-tissue masses. The hindfeet of 10 normal volunteers and 17 patients were scanned in the coronal and axial transverse planes. The articular surfaces of the tibia, talus, and calcaneus were assessed, as were the relationships of each bone to the others. Normal subjects had markedly symmetrical hindfeet . The "heel valgus angle" (relating the calcaneus to the tibia) was 5.2 +/- 1.6 degrees (mean +/- standard error of the mean). The "sustentacular angle" (indicating the angle of elevation of the sustentaculum tali at the midsubtalar joint) was 18.3 +/- 1.3 degrees. The "medial offset" of the talar head with respect to the calcaneus (measured at the anterior subtalar joint) averaged 5.2 +/- 1.8 mm. Patients with rheumatoid arthritis had erosions involving both sides of the subtalar joint, leading to talocalcaneal alignment abnormalities. In patients with pes planovalgus the heel valgus angle was greater and the elevation of sustentaculum tali lower in the foot that was most severely affected. Bony talocalcaneal fusions, fractures, and the erosions of pigmented villonodular synovitis were detected on CT. The pattern of postoperative bone healing after attempted subtalar fusion could be demonstrated. We conclude that CT is a useful tool for pre- and postoperative evaluation of the hindfoot. | |
| 6426050 | Immunosuppressive actions of gold salts. | 1983 | In rheumatoid arthritis both lymphocyte-mediated and antibody-mediated immune reactions are important for the inflammatory lesions. In vivo activated B lymphocytes/plasma cells, T lymphocytes and monocytes/macrophages (Mo) are intimately involved in the disease process. Several clinical observations suggest an immunosuppressive action of gold salts. In humans, gold salts interfere with a number of Mo functions in vitro, including cellular interactions between Mo and T lymphocytes. Some workers have shown that the activation of human T lymphocytes is inhibited by gold salts, most probably secondary to an inhibition of Mo-T cell cooperation. Recent experiments indicate that gold salts also affect the in vitro differentiation of human B lymphocytes in response to polyclonal activators. Both the gold atom and the SH group seem to be important for the immunosuppressive actions of gold salts. | |
| 3876079 | Arthritis and coeliac disease. | 1985 Sep | We report six patients with coeliac disease in whom arthritis was prominent at diagnosis and who improved with dietary therapy. Joint pain preceded diagnosis by up to three years in five patients and 15 years in one patient. Joints most commonly involved were lumbar spine, hips, and knees (four cases). In three cases there were no bowel symptoms. All were seronegative. X-rays were abnormal in two cases. HLA-type A1, B8, DR3 was present in five and B27 in two patients. Circulating immune complexes showed no consistent pattern before or after treatment. Coeliac disease was diagnosed in all patients by jejunal biopsy, and joint symptoms in all responded to a gluten-free diet. Gluten challenge (for up to three weeks) failed to provoke arthritis in three patients tested. In a separate study of 160 treated coeliac patients attending regular follow up no arthritis attributable to coeliac disease and no ankylosing spondylitis was identified, though in a control group of 100 patients with Crohn's disease the expected incidence of seronegative polyarthritis (23%) and ankylosing spondylitis (5%) was found (p less than 0.01). Arthritis appears to be a rare manifestation of coeliac disease. This relationship may provide important clues to the role of gastrointestinal antigens in rheumatic diseases. |