Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 3909405 | Radiologic review: the rheumatoid cervical spine. | 1985 Feb | We have reviewed the multiplicity of lesions present in the cervical spine in the adult with RA. The clinicoradiographic correlations are presented, and the techniques available for appropriate investigation are suggested. Readily available, conventional radiology provides useful information for the majority of patients. A standardized system of weighting and grading roentgenographic changes would be a welcome area of future research. Myelography and angiography should be considered in every patient before cervical spine surgery. CT evaluation should be reserved for those without a readily appreciable cause for myelopathy and those undergoing cervical surgical procedures. | |
| 221970 | Cyclic nucleotides in joint fluid in rheumatoid arthritis and in Reiter's syndrome. | 1979 | Levels of cyclic adenosine 3',5'-monophosphate (cAMP) and cyclic guanosine 3',5'-monophosphate (cGMP) have been investigated in joint fluid in inflammatory arthropathies. A disturbed balance between cAMP and cGMP due to a depressed level of cAMP was found in rheumatoid arthritis (RA) and Reiter's syndrome, in comparison with patients with osteoarthritis. No correlation could be demonstrated between the absolute levels of cAMP or cGMP and the degree of local inflammatory activity, white cell count, or lysosomal enzyme activity in the joint fluid. Intra-articular injection of epinephrine showed just as good an effect on local pain as betamethasone (Cellestona), but the steriod reduced the swelling more effectively. An increase in intracellular levels of cAMP at 20 min was observed following injection of epinephrine with a slight change in cGMP. Intra-articular injection of dibutyryl-cAMP (db-cAMP) produced a marked easing of local pain and swelling in each of the 4 patients so treated. It is concluded that stimulation of the beta-adrenergic system or injection with db-cAMP may be beneficial in rheumatoid inflammation. | |
| 6606847 | Long-term prognosis of monoarthritis. A follow-up study. | 1983 | During 1973-75, a total of 446 patients with recent arthritis were examined. The diagnosis in 32 cases was non-classified monoarthritis. After the 3-9 years' follow-up of these 32 patients, two seropositive, definite rheumatoid arthritis cases (6%), and one ankylosing spondylitis case were noted. In the remaining patients the diagnosis was still non-specific arthritis. Of the 31 patients tested, 39% were HLA-B27-positive. The difference between this and the HLA-B27-positivity in the normal Finnish population (14%) is statistically significant (p less than 0.005). At the end of the follow-up the good prognosis of monoarthritis was confirmed: only one erosion developed in one patient's hands or feet. | |
| 6378106 | Enhanced bacterial phagocytosis by peripheral blood monocytes in rheumatoid arthritis. | 1984 Jun | To assess the functional state of peripheral blood monocytes in rheumatoid arthritis, we have measured phagocytosis of Staphylococcus aureus and Proteus mirabilis in 48 patients and 28 controls. Using radiolabelled bacteria preopsonised in normal human serum we have demonstrated significantly enhanced uptake of both organisms by patients' monocytes: (Median % uptake Staph. aureus: patients = 35.8; controls = 19.3; p less than 0.001. Median % uptake P. mirabilis: patients = 32.3; controls = 19.8; p less than 0.01.) These results indicate that patients' monocytes exist in an activated state, which may be important in the pathogenesis of rheumatoid arthritis. | |
| 7458432 | Spontaneous cytotoxicity of rheumatoid and normal peripheral blood mononuclear cells again | 1980 Dec | By measuring spontaneous cytotoxicity of unfractionated peripheral blood mononuclear cells from patients with rheumatoid arthritis and from normal individuals against 4 human lymphoblastoid cell lines we have been unable to demonstrate any preferential recognition of antigens on these cell lines by rheumatoid patients. | |
| 120005 | Pulmonary damage associated with gold therapy. A report of two cases. | 1979 Dec | Two patients suffering from rheumatoid arthritis developed respiratory symptoms during sodium aurothiomalate treatment. Chest radiographs showed bilateral diffuse pulmonary infiltrates in both cases. In one patient the symptoms subsided and the chest radiograph became normal within 6 months after gold therapy was discontinued and steroids added. In the other patient the condition resulted in an irreversible lung damage. | |
| 6333315 | Antibody dependent cell-mediated cytotoxicity in different forms of rheumatoid arthritis p | 1984 Sep | The activity of peripheral blood lymphocytes from 61 patients with rheumatoid arthritis (RA) was examined in the antibody dependent cell-mediated cytotoxicity (ADCC) test in the allogenous system. The control group consisted of 86 healthy donors. Also, the effect of sera from RA patients upon the normal lymphocytes in ADCC was studied and the EA rosette test was performed. A significant decrease in the cytotoxic activity of peripheral blood lymphocytes was found in RA patients, this being dependent on the form of RA rather than laboratory evidence of the inflammatory process. Particularly poor cytotoxic activity was revealed in rheumatoid subjects with the coexisting laboratory evidence of systemic lupus erythematosus (SLE) and amyloidosis. It seems that factors inhibiting lymphocyte cytotoxicity in the ADCC test are of a complex nature. | |
| 7025177 | Tiaprofenic acid in the treatment of rheumatoid arthritis. | 1981 Aug | Tiaprofenic acid is a new non-steroidal anti-inflammatory agent. Two studies of its use in treating rheumatoid arthritis are reported here. In the first, tiaprofenic acid was compared with phenylbutazone in a double-blind cross-over study of 10 weeks' duration. Both drugs were significantly better than placebo and equal in efficacy with each other. The second study was a long-term open trial of tiaprofenic acid in 20 patients. The drug has been well tolerated over periods of up to three years and its effects in reducing the symptoms and signs of rheumatoid arthritis have been maintained. Side-effects were very few in both studies. Gastro-intestinal symptoms were the most frequently reported. One patient developed melaena three years after starting the drug. | |
| 978665 | Acute leukemia in rheumatoid arthritis treated with cytotoxic agents. | 1976 Sep | Acute leukemia is described in two patients treated with cytotoxic agents for a destructive, seropositive rheumatoid arthritis. Both patients had received longterm azathioprine therapy. In addition, one patient had been treated with cyclophosphamide, the other with melphalan. Chromosomal abnormalities were noted in both patients. Studies in one patient included colony forming units, ferrokinetics, electron microscopy of bone marrow, and autopsy examination. All reports of acute leukemia associated with cytostatic drugs in the literature to date are reviewed and the possible mechanisms discussed. It is suggested that patients with rheumatoid arthritis treated with azathioprine and alkylating agents may have an increased risk of developing a therapy-related acute leukemia. | |
| 7424197 | [Synovial membrane changes in early rheumatoid arthritis. I. Histological studies]. | 1980 Jan | The histological and histochemical findings in synovial membranes of 13 patients with early rheumatoid arthritis (duration not more than 6 months; clinical follow-up at least 2 years) have been compared with 16 late cases of definite RA (ARA criteria). The authors intended to investigate the dynamic evolution of rheumatoid synovitis and to analyze the full-fledged changes with reference to diagnosis and pathogenesis of RA. Although the basic pattern of reaction is the same, the following peculiarities are found in early RA: 1) A band-like mucoid swelling of the synovial adventitia, histochemically with increase of acid glucosaminoglycans; 2) more frequent occurrence of vasculitis; 3) less marked infiltration with lymphocytes and plasma cells; 4) absence of gross fibrin insudation and granulocyte infiltration; 5) absence of diffuse fibrosis and hyalinosis. For diagnostic purposes it is also important that proliferative reactions can be found but are much less marked than in late cases. In conclusion, the early morphological findings do not allow more than the suspicion of RA. The combined mucoid swelling of the ground substance and vasculitis together with further signs of proliferation and exsudation are most important. With reference to the pathogenesis of RA, the authors insist on the frequent vasculitic changes and the early occurrence of immuno-competent cells which are the cytological condition of immunological reactions. | |
| 693774 | The significance of certain dreams reported by psychosomatic patients. | 1978 | Several types of dreams reported by psychosomatic patients with alexithymic characteristics are presented. Two special features of the dreams are noted: (1) the dreams contain events which are very traumatic and (2) the protagonists of the dreams failed to fully perceive their own feelings. It is postulated that the failure of the protagonists to fully perceive their own feelings played an important role in fostering the development of the traumatic events. Feelings such as anxiety and sadness are key signals which incite the ego of the dreamer to set protective operations into motion. The diminution of awareness of these feelings may, therefore, delay the implementation of protective operations to a point which allows the traumatic events to progress dangerously far. It is interesting to note that the few psychosomatic patients without alexithymic characteristics who were included in my series reported a type of dream which was identical to one of the types of dreams reported by patients with alexithymic characteristics. This concurrence suggests the possibility that the dreams form a link between the psychologies of these two sub-groups of psychosomatic patients. | |
| 130225 | Type III collagen: A major constituent of rheumatoid and normal human synovial membrane. | 1975 | The findings establish that type III collagen is a major constituent of grossly proliferated rheumatoid and normal synovium. Unlike the collagen of normal synovium most of that in rheumatoid tissue could be solubilised by pepsin at 4 degrees C. Moore than half the pepsin-solubilised collage was identified as type III, the remainder being type I, by CM-cellulose chromatography; SDS-polyacrylamide electrophoresis with and without reduction of disulphide bonds; and amino acid analysis. Moreover, at least half the total collagen in several samples of normal as well as rheumatoid tissue was clearly type III when cyanogen bromide-derived peptides were run on SDS-polyacrylamide electrophoresis and compared with peptides prepared from purified types I and III collagens. This conclusion was supported by the isolation on phosphocellulose and quantitation by amino acid analysis of the collagen peptides alpha(1)CB2 and alpha(III)CB2 from a cyanogen bromide digest of rheumatoid synovium. | |
| 4048880 | Audit of closed synovial biopsy in the diagnosis of inflammatory joint disease. | 1985 | In a prospective study, the clinical features and synovial histopathology of 78 patients with joint disease were compared. Nineteen patients had early rheumatoid disease, 19 chronic rheumatoid, 17 chondrocalcinosis or osteoarthritis, 10 persistent monoarthritis and 14 other miscellaneous arthropathies. After semiquantitative assessment of the degree of inflammatory infiltration, increase in vascularity, synovial hypertrophy and ulceration and fibrin deposition biopsies were categorized as either normal, or slightly or severely abnormal. The highest incidence of severely abnormal biopsy was in patients with chronic rheumatoid disease and miscellaneous forms of arthritis. Major histological abnormalities were uncommon in osteoarthritis, chondrocalcinosis and persistent monoarthritis. Generally, histology was of little help in differential diagnosis, but in early rheumatoid disease there was a relationship between the clinical degree of knee joint disease and the category of histological change. In these patients, general disease activity was reassessed at least 18 months after biopsy. All those with severely abnormal biopsies had persistent or severe persistent rheumatoid disease, whereas 3 of the 4 patients with normal biopsies had no evidence of active synovitis. | |
| 484665 | Epithelial deposition of gold in the cornea in patients receiving systemic therapy. | 1979 Sep | Epithelial gold deposits were demonstrated biomicroscopically in 13 of 15 patients receiving gold therapy for rheumatoid arthritis. Only one of six further patients who had received gold therapy in the past showed such deposits. Deposits appeared with a cumulative dose of sodium thiomalate exceeding 100 mg. The earliest appearance was after seven months of therapy and deposits were visible in one subject as long as nine months after therapy had stopped. The density of deposit does not appear to increase over the whole of the dose range, possibly as a result of the effect of epithelial turnover. No symptoms attributable to the deposit were encountered in any patient. | |
| 71813 | Lichen planus and acne provoked by gold. | 1977 | A 58-year-old man with rheumatoid arthritis developed lichen planus during treatment with gold. Four months after cessation of treatment, a severe acne with comedones, papules, pustules, and small cystic elements broke out. No connection could be demonstrated between the eruption and other drugs or chemicals. Acne provoked by gold seems not to have been described elsewhere. The case history confirms that gold treatment, even in the same patient, can give rise to a wide range of skin disturbances, which in many cases do not break out until long after the drug has been withdrawn. | |
| 6308812 | [Cervical neurologic complications of rheumatoid arthritis. Indications for surgical treat | 1983 Jun 16 | The analysis of 8 cases of rheumatoid arthritis involving the cervical spine and resulting in neurological complications leads the authors to change their therapeutic approach. After a study of etiopathological aspects they advocate wider indications of surgical treatment. Clinical and radiological criteria are defined and operative risks are described. | |
| 7172504 | A serum AA-like protein as a common constituent of secondary amyloid fibrils. | 1982 Sep | Amyloid fibrils, purified from the spleen of four patients with amyloidosis associated with rheumatoid arthritis, had protein AA as a major protein. Besides this protein, all four amyloid fibril preparations contained a protein which in size, amino acid composition and N-terminal amino acid sequence was the same as the postulated serum precursor of protein AA, serum AA (SAA). The SAA-like amyloid fibril protein had a tendency to aggregate in neutral conditions, a phenomenon which is also seen in SAA but not in protein AA. | |
| 403043 | Effects of a gold salt on lymphocyte responses. | 1977 Feb | The effects of sodium aurothiomalate (SATM) on certain lymphocyte functions in vitro were tested. Lymphocytes were obtained from both healthy donors and patients with rheumatoid arthritis (RA). SATM depressed tritiated thymidine uptake in lymphocyte cultures stimulated by phytohaemagglutinin, and in a mixed lymphocyte response assay. Cytotoxic effector cell generation assayed by percentage specific 51Cr release was also depressed by SATM using lymphocytes from healthy donors, and from patients with RA. These effects imply that SATM inhibits both exogenous thymidine uptake, and blastogenesis, and suggest that gold salts may act in RA by interference with T-cell dependent functions. | |
| 6644700 | Longterm effects of cyclophosphamide on granulocyte colony formation in patients with rheu | 1983 Oct | Longterm cytotoxic therapy, particularly with alkylating agents, is frequently associated with the development of second neoplasms, particularly acute myeloid leukemia. Twelve patients with classic, progressive rheumatoid arthritis (RA), treated with a cytotoxic agent, cyclophosphamide, from 1969 to 1974 at the University of Colorado Health Sciences Center were reassessed for current status of the granulocytic system. Bone marrow biopsies were investigated histologically and the number of granulocyte precursor cells judged using colony forming cells in culture (CFU-C). Control bone marrow biopsies were done on 8 patients with classic, progressive RA who had not taken cyclophosphamide as well as 16 healthy controls. Colony forming cell numbers in patients with RA who had been treated with cyclophosphamide were significantly lower compared to patients with RA who had not received cyclophosphamide and normal controls. These data suggest that cyclophosphamide may cause suppression of the hematopoietic system that does not totally recover even after long periods of time. | |
| 535499 | Gold nephropathy in rheumatoid arthritis and in juvenile chronic arthritis. | 1979 | During gold therapy a patient with rheumatoid arthritis developed nephrotic syndrome, and a patient with juvenile chronic arthritis proteinuria. Electron microscopic examination of bioptic specimens of the kidneys revealed in both instances membranous glomerulonephritis with typical epimembranous deposits and intracellular gold inclusions. Immunofluorescent examination performed only in the second patient revealed that the deposits in the wall of the glomerular capillaries contain IgG which suggests an immunocomplex mechanism of the development of the renal disease, induced very probably by chrysotherapy. |