Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 6743969 | Diffuse alveolitis on a small dose of penicillamine. | 1984 Aug | A 60-year-old man with seropositive rheumatoid arthritis developed rapidly progressive dyspnoea and bilateral pulmonary infiltrates on short exposure to 50 mg penicillamine daily. He made a satisfactory recovery following cessation of penicillamine therapy and the addition of prednisolone. This case has been reported to the Committee on Safety of Medicines and we would like to emphasize that the possibility of penicillamine-induced lung disease should be recognized, even on a small dose of short duration. | |
| 7043499 | Effects of corticosteroids on articular cartilage: a review of the literature. | 1982 Jun | Physical therapists evaluate and treat patients who simultaneously may be receiving corticosteroid compounds to reduce inflammation and pain associated with certain diseases such as rheumatoid arthritis and osteoarthritis. Both beneficial and deleterious effects of corticosteroids on articular cartilage have been reported. Physical therapists and others treating joints with pathological conditions should understand these effects and use this knowledge to establish and modify therapeutic management programs for patients with joint dysfunction. A review of the literature is presented. | |
| 63189 | [Cytodiagnosis of the synovial fluid]. | 1976 Aug 15 | In a survey in a general part the differential-diagnostic approach in the establishment of cytological findings of the arthrocentesis for the judgment of the normal and pathologically changed synovial fluid are described. Especially the differential-diagnostic possibilities by constellations of the findings from determination of the total number of leucocytes, the differential cell picture and the determination of the individual signs characteristic for a disease are demonstrated. A special part deals with the assessment of the cytologic findings of the arthrocentesis for the diagnosis, the local and general judgment of the activity and the judgment of the therapeutic success of medicamentous and operative measures in rheumatoid arthritis with the help of the cytology of the puncture of a joint. | |
| 6118581 | The importance of iron in rheumatoid disease. | 1981 Nov 21 | The hypothesis is that iron, which accumulates in rheumatoid synovial membrane and fluid contributes to the variable expression of rheumatoid disease in two ways. Firstly, it catalyses oxidative radical reactions which lead to the formation of the hydroxyl radical and subsequent lipid peroxidation. Hydroxyl radicals and lipid peroxidation cause extensive disruption of cellular and organelle membranes and promote inflammatory tissue damage. Secondly, the infiltration of the rheumatoid synovium by chronic inflammatory cells may be due not to an antigenic process but to the tendency for these cells, which have receptors for iron-binding proteins, to migrate towards deposits of iron. | |
| 2996290 | Rheumatoid arthritis cells in experimental pleuritis in mice. | 1985 Sep | In mice immunized with bovine fibrin, the same antigen was applied to the pleural cavity. A granulomatous pleuritis appeared affecting both the visceral and the parietal pleura, especially located around the antigen particle. Rheumatoid arthritis (RA) cells were constantly found in the pleural cavity when pleural lesions were present. This immunological, granulomatous pleuritis is the first experimental model for the study of RA cell-positive types of pleurisy in humans. | |
| 4218731 | [Atrio-ventricular block in rheumatoid polyarthritis. Histological study of the His-Tawara | 1974 Oct | A histological study of the conduction pathways was performed by serial sections in two patients who died with atrio-ventricular block in the course of rhumatoid arthritis. In the first case, the conduction disturbance was preceded by attacks of supra-ventricular paroxysmal tachycardia. The His-Tawara system was wholly infiltrated by a cast of lympho-plamocytes starting from rhumatoid nodules located at the base of both mitral and tricuspid valves and at the root of the aorta. The sinus node was the seat of a common fibrosis. In the second case, the atrio-ventricular block was secondary to amylosis which predominated in the central fibrous node and in the adjacent small coronary vessels. The His-Tawara system was completely destroyed down to its bifurcation. The sinus node was normal. | |
| 515782 | Renal vein thrombosis associated with nephrotic syndrome and gold therapy in rheumatoid ar | 1979 Dec | In this case of renal vein thrombosis secondary to a nephrotic syndrome, we postulate renal disease resulted from gold therapy. We know of no previous report relating gold toxicity and renal vein thrombosis. It should be emphasized that with increasing use of gold, proteinuria and nephrotic syndrome may be more common than once suspected and, when present, predispose to the development of renal vein thrombosis. | |
| 6226122 | Continuous ambulatory peritoneal dialysis in the physically disabled. | 1983 Oct 8 | Continuous ambulatory peritoneal dialysis (CAPD) has been increasingly used as maintenance home dialysis by patients in end-stage chronic renal failure since it was first described in 1976. The procedure is hazardous in the physically disabled and blind and in non-compliant patients. This paper describes 2 patients, one with rheumatoid arthritis and the other with Volkmann's ischaemic contracture of the left forearm, who are able to carry out CAPD successfully with the aid of bioengineering. | |
| 4059595 | [Erosive arthrosis of the hand. Criteria of the differential diagnosis]. | 1985 May | Erosive osteoarthritis (EOA) is a peculiar form of osteoarthritis, characterized by inflammatory destructive changes (erosions) in the interphalangeal joints, with relative sparing of the metacarpophalangeal joints, and frequent involvement of the trapeziometacarpal joint. Linear periosteal bone apposition is also commonly reported. In EOA, erosions tend to occur exclusively in the subchondral cortex of joints, causing in DIP joints a typical "gull wings" configuration of bones of distal phalanges, whereas in psoriatic arthritis (PA) and in rheumatoid arthritis (RA) the "bare areas" are primarily affected. However, such "gull wings" erosions are nonspecific, and may be observed in the late stage of PA in the IP joints, or RA in the PIP joints. | |
| 6438454 | Aurothioglucose in rheumatoid arthritis. Outcome of treatment in patients intolerant of so | 1984 Sep 15 | Forty-three patients in whom treatment with sodium aurothiomalate was discontinued because of adverse reactions that either were relatively severe or recurred on rechallenge received treatment with aurothioglucose in oily base. Thirty-six of them had rheumatoid arthritis, four had psoriatic arthritis and three had juvenile chronic arthritis. Aurothioglucose therapy was introduced cautiously and increased gradually to a maintenance regimen, usually 5-20 mg/week, administered by intramuscular injection. The clinical response was good in 25 patients (60%), 14 of whom continued to receive aurothioglucose therapy on a long-term basis. Adverse reactions to aurothioglucose developed in 17 patients (40%); these were generally mild, and, in all but four patients, were of the same type as those induced by sodium aurothiomalate therapy. Results show that aurothioglucose in oily base may be successfully administered in a low-dose regimen to selected patients who are intolerant of sodium aurothiomalate. | |
| 105913 | Increased excretion of two sialic acid-containing trisaccharides in the urine of patients | 1978 Dec | The urinary excretion of sialic acid-containing trisaccharides in patients with active rheumatoid arthritis was studied. Sialyl-lactose and sialyl-N-acetyllactosamine were identified and their excretion patterns studied by thin layer and gas chromatography. The urinary output of sialyl-lactose was greater in patients with active rheumatoid arthritis (48.2 +/- 6.1 mg/24 h, SEM, n = 6) than in healthy subjects (19.8 +/- 3.7 mg/24 h, SEM, n = 5; P less than 0.01). The excretion of sialyl-N-acetyllactosamine was also higher in the rheumatoid group (18.5 +/- 2.1 mg/24 h, SEM, n = 6) than in the controls (11.1 +/- 1.2 mg/24 h, SEM, n = 5; P less than 0.05). The qualitative excretion patterns of the sialyl-oligosaccharide fraction were similar for the two groups as judged from the thin layer chromatograms. Correlating the results with the clinical state of the patients with rheumatoid arthritis suggests that the urinary level of the sialyl-oligosaccharides reflects the activity of the disease. A proposed mechanism for the increased excretion of sialic acid-containing trisaccharides in rheumatoid arthritis is presented. | |
| 750113 | Metabolism of factor B of serum complement in rheumatoid arthritis. | 1978 Oct | An increased rate of catabolism of radio-iodinated Factor B has been shown in five out of ten patients with rheumatoid arthritis. Serum levels of Factor B were normal, the increased catabolism being matched by increased synthesis. The patients showing high catabolic rates had more manifestations of extra articular disease than did those with normal catabolic rates and they had higher rheumatoid factor titres. In seven patients, the catabolic rate for Factor B correlated significantly with the rate of IgG catabolism. In this series, the Raji-cell assay for immune complex-like material was in the normal or near normal range in all but one patient. | |
| 1108503 | Collagen antibodies and collagen- anticollagen immune complexes in rheumatoid arthritis. | 1975 Nov | Serum, synovial fluid and synovial fluid cells of 14 patients with classic rheumatoid arthritis and of 5 controls were investigated serologically in regard to rheumatoid factors and collagen antibodies and by immunofluorescence double staining in regard to localization of collagen and gammaglobulin in fluid cells. Three patterns of staining were observed: a) gammaglobulin inclusions, b) gammaglobulin and collagen in identical localization, c) collagen inclusions. While distinct staining for gammaglobulin appeared only in seropositive cases, collagen inclusions were only observed in RA, however in seropositive and seronegative cases. In 5 RA cases collagen and gammaglobulin were demonstrated additionally in such identical localization that conclusion in regard to collagen-anticollagen immune complexes seems justified. 9 of 14 RA cases had collagen antibodies, all cases were collagen antibody positive which had collagen and gammaglobulin in identical localization in same inclusions. | |
| 4075586 | Reticuloendothelial Fc receptor function in patients with Sjogren's syndrome. | 1985 Sep | The functional status of the reticuloendothelial Fc receptor in patients with Sjogren's Syndrome was examined by determining the clearance from the circulation of IgG coated erythrocytes which had been obtained from a single donor. 18 patients with Sjogren's Syndrome were studied and the results compared with those obtained from 18 patients with Rheumatoid Arthritis and 27 healthy controls. Abnormal Fc mediated clearance was observed in 3 individuals with Sjogren's Syndrome and 2 patients with Rheumatoid Arthritis. Extraglandular disease was not associated with abnormal Fc function and there was no correlation between the clearance rates and the immune complex levels, complement levels or rheumatoid factor titre. A comparison of the clearance rates obtained using the patients own red cells with those derived from using a single donor showed that the source of cells used had a significant effect on the clearance rate. Our findings provide no support for the idea that defective Fc function may be of pathogenic significance in the development of more extensive disease in patients with Sjogren's Syndrome. | |
| 4426972 | Serum ferritin concentration as an index of storage iron in rheumatoid arthritis. | 1974 Oct | Serum ferritin concentration has been compared with semi-quantitative histochemical estimates of bone marrow iron deposits in 60 anaemic patients with rheumatoid arthritis. There was considerable variation in the visual assessment of iron stores made by different observers. Serum ferritin appears to be a particularly sensitive index of iron status when stores are low. The best means of detecting iron deficiency in rheumatoid arthritis are discussed. | |
| 6609435 | Bleeding tendency possibly related to increased plasma antithrombin III activity in patien | 1984 May | A patient with chronic rheumatoid arthritis under treatment with steroids was given piroxicam (Feldene) for relief of pain and disability. Overt cutaneous and occult gastrointestinal bleeding developed after two months of treatment. Bleeding subsided and laboratory values returned to normal upon discontinuation of the drug. | |
| 7351481 | Measure of rheumatoid factor in human sera by passive haemagglutination of human erythrocy | 1980 | Serum rheumatoid factor in sero-positive patients with rheumatoid arthritis may be measured by passive haemagglutination of trypsin-treated human red cells linked with heat-aggregated human IgG by chromic chloride. The results show excellent correlation with those obtained with the classical Rose-Waaler test. The sera may be tested unheated and do not require preliminary absorption with red cells. By this test procedure it should also be possible to analyse the species, allotypic and conformational specificity of different rheumatoid factors. | |
| 6660241 | Methotrexate therapy in rheumatoid arthritis: 15 years experience. | 1983 Dec 30 | An increasing amount of clinical data indicates that low-dose methotrexate therapy for rheumatoid arthritis is both effective and free of serious side effects. Since 1967 we treated 78 patients with definite or classic rheumatoid arthritis who showed inadequate response to conventional therapy. Up to 15 mg of methotrexate was given weekly by the intramuscular route. Morning stiffness, severity of pain at rest and with activity, extent of active synovitis, functional capacity, change in steroid dosage, complete blood count, erythrocyte sedimentation rate, and gamma glutamyl transpeptidase were monitored. Overall assessment indicated that 45 of the 78 (58 percent) patients showed marked improvement or complete remission, usually within four weeks. When maximum improvement was obtained, most patients were switched to oral therapy with a variable degree of success, and dosage was decreased as tolerated. No serious toxicity was noted. In 34 patients a total of 67 liver biopsy specimens were obtained, some after as long as 15 years of therapy. Minor changes observed are the same as in patients with rheumatoid arthritis not treated with methotrexate. Because the risks did not appear justified, routine annual biopsies were discontinued. In contrast to other cytotoxic drugs, no carcinogenesis has been demonstrated with methotrexate. It appears that methotrexate is approximately as effective as intramuscular gold and D-penicillamine but that it has a quicker onset of response and less serious toxicity. | |
| 88519 | A technique for investigating the antigenicity of cultured rheumatoid synovial cells. | 1979 Mar | Antisera to rheumatoid and nonrheumatoid synovial cells were prepared by: intraarticular injection of rabbits with these cells, subsequent synovectomy, and autologous immunization of each animal with the cultured rabbit synovial cells, or homogenized whole rabbit synovial membrane. Resultant antisera were studied by immunofluorescence and 51chromium cytotoxicity tests against other cultured rheumatoid and nonrheumatoid cells. Activity of positive sera could be removed by absorption with nonrheumatoid cells, except for one antiserum which appeared to produce immunofluorescent staining specific for rheumatoid cells. | |
| 1098671 | The therapeutic activity of 1-(p-chlorobenzoyl)-5-methoxy-2-methylindole-3-acetic acid mon | 1975 Mar | A new nonsteroidal anti-inflammatory agent, 1-(p-chlorobenzyl)-5-methylindole-3-acetic acid monohydrate glucosamide (glucametacine, Teoremac¿), was used in the treatment of a total of 39 patients including 31 cases of rheumatoid arthritis, 3 of ankylosing spondylitis, 1 of psoriatic rheumatism, 1 of chronic chondrocalcinosis and 3 of arthrosis. Teoremac was given for 14 days at a dosage of 420 mg/day. The drug was shown to be more or less active in all the patients except 4. The improvement in the various clinical parameters of rheumatoid arthritis studied was statistically significant. The side effects recorded were headache, which was severe in only 1 case, and "minor" disturbances of the gastro-intestinal tract. A double blind crossover trial was carried out in 15 patients with rheumatoid arthritis to compare the action of Teoremac (420 mg/day for 14 days) with that of indometacin (100 mg/day for 14 days). Under the conditions of the trial, the clinical findings showed Teoremac to be slightly superior to indometacin, but the difference was not significant statistically. |