Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 1127136 | Clinical evaluation of d-2-(6'-methoxy-2'-naphthyl)propionic acid (naproxen) in rheumatic | 1975 Apr | A double-blind, crossover trial with 40 patients suffering from classic or definite rheumatoid arthritis was undertaken to obtain a clinical evaluation of naproxen in the disease. Each patient received either naproxen (500 mg/day) or placebo for 20 days and was then switched to the other compound for 20 days. For final evaluation, 22 cases were eliminated for various reasons, leaving 18 patients: seven cases of classical rheumatoid arthritis and 11 cases of definite rheumatoid arthritis. Optimum or very good efficacy of the active compound was present in 66.6 per cent of the cases versus 11.1 per cent of the placebo group. Doubtful or nil activity was observed in 66.6 per cent of the cases receiving placebo versus 16.6 per cent for naproxen. In addition, of the 22 cases that were eliminated from the final evaluation, but which were seen for the first ten-day follow-up visit while taking the active drug, optimum or very good efficacy was seen in 13. Therefore, this trial showed that naproxen achieved antiinflammatory and analgesic activity far superior to that observed with placebo. | |
| 601432 | Penicillamine in rheumatoid arthritis: wound healing, skin thickness and osteoporosis. | 1977 Nov | D-Penicillamine alters the normal metabolism of collagen by inhibiting cross-linking and protein synthesis. This could affect wound healing, accelerate skin thinning and possibly exaggerate the osteoporosis of rheumatoid disease. The mean time to wound healing after 42 orthopaedic surgical operations in 21 patients treated with penicillamine was 19.8 (+/- 13.1) days. Compared with an earlier study, these results suggest that the drug has a comparable effect on would healing to corticosteroids given for three years. Skinfold thickness over the fourth metacarpal of the dominant hand was measured in 28 cases before and during penicillamine treatment. There was a significant decrease both in the first and second four-month periods of treatment (P less than 0.005 and P less than 0.01). Corticosteroids in constant dose did not have an additive effect. In view of the wound healing findings the significance of these results must await further sequential measurements. The normal progression of osteoporosis over three years was documented in 70 patients who had not received penicillamine. Penicillamine reversed this trend in 35 patients after one year of treatment (P less than 0.005). The results confirm that the osteoporosis is related to disease severity rather than drug therapy. | |
| 4071266 | Posterior surgical stabilization for atlantoaxial subluxation in rheumatoid arthritis. | 1985 Sep | Twelve patients with rheumatoid arthritis involving the cervical spine were treated with posterior surgical stabilization for atlantoaxial instability. There were two occiput C2 fusions with one death and ten C1-2 fusions with nine successful fusions, giving an overall 84% satisfactory results and 90% satisfactory results in the C1-2 fusions alone. It is proposed that careful attention to operative positioning and postoperative management are responsible for the better results reported in this series than recent reports of operative treatment of similar patients. The use of halo traction intraoperatively with careful attention to positioning of the neck and halo cast postoperatively are advocated. | |
| 7122338 | Gold for rheumatoid arthritis: current perspectives. | 1982 Sep | Gold therapy induces remission in many patients with rheumatoid arthritis (RA). This fact, coupled with improved understanding of gold's mechanism of action and better ability to monitor its side effects, has led to a resurgence of popularity of this drug in the treatment of RA. Gold should be used as an adjunct when basic therapy, ie, aspirin or nonsteroidal antiinflammatory drugs, rest, and physical therapy, fails. Careful patient selection and education; early attention to side effects, especially mouth and skin reactions; and willingness to increase the dosage if the usual regimen does not bring about a satisfactory response, all contribute to successful use of gold. Although only injectable forms of gold are now available in the United States, an oral form that seems to be less toxic is being tested. | |
| 7420338 | Is there a lower incidence of deep venous thrombosis after joint replacement in rheumatoid | 1980 Jul | Patients with rheumatoid arthritis (RA) and osteoarthritis (OA) were compared for the incidence of deep venous thrombosis (DVT) after total hip replacement (THR). RA patients after total knee replacement (TKR) were also compared for the incidence of DVT. The relative risk of OA patients developing DVT after THR was 2.3 times that of RA patients. In RA patients after TKR, the chance of DVT was 4.8 times greater than after THR, implying that added stress in knee surgery can overcome the inherent protection RA patients may have. Although salicylates may be protective, firm conclusions regarding the effect of drugs, including corticosteroids on the development of DVT could not be made. | |
| 6725317 | Arthrodesis of the first metatarsophalangeal joint for hallux valgus in rheumatoid arthrit | 1984 Jun | We reviewed the results of reconstruction of the fore part of the foot in rheumatoid patients by arthrodesis of the first metatarsophalangeal joint. The follow-up averaged 4.1 years (range, 2.0 to 7.25 years). Eighteen feet in eleven women were operated on. Twelve feet underwent total reconstruction of the fore part: arthrodesis of the first metatarsophalangeal joint and excision of all of the lesser metatarsophalangeal joints. Six feet underwent subtotal reconstruction, which included arthrodesis of the first metatarsophalangeal joint. The results were classified as excellent in fourteen feet, good in two, and fair in two. There were no poor results. Metatarsophalangeal bone fusion was achieved in all but one foot (fusion rate, 94 per cent). The one fibrous ankylosis was painless, with satisfactory function. Interphalangeal degenerative joint disease was a radiographic but not a clinical sequela. Arthrodesis of the first metatarsophalangeal joint provided stability that permanently corrected deformity, permitted the patients to wear ordinary shoes, and, in combination with excisional arthroplasty of involved lesser metatarsophalangeal joints, relieved disabling pain in the fore part of the foot. | |
| 3864577 | Comparison of the effects of different anti-inflammatory drugs on synovial fluid prostanoi | 1985 Sep | The effects of one-day treatment with nine nonsteroidal anti-inflammatory drugs and prednisolone on human synovial fluid concentrations of prostanoids were studied. The doses were calculated so as to be approximately equipotent according to clinical experience and the recommendations of the manufacturers. Most of the drugs used reduced clearly PGE2 and TxB2 levels in synovial fluid, but only a slight diminution in 6-keto-PGF1 alpha values was found. Carprofen, diclofenac, indomethacin, naproxen and tolfenamic acid reduced significantly the synovial fluid PGE2 concentrations. Diclofenac and indomethacin also reduced significantly the synovial TxB2 concentrations. | |
| 6238752 | Immunoregulatory changes in autoimmune disease. | 1983 | Peripheral blood T cell subpopulations were determined in patients with various rheumatic diseases [rheumatoid arthritis (RA); ankylosing spondylitis (AS); reactive synovitis (RS)]. No significant variation in OKT3+ cells was found among these groups. In RA, an increased percentage of OKT4+ was found in relation to the control group. For the other groups no difference was observed. In RA, a decreased percentage of OKT8+ cells was observed. Thus, the immunologic imbalance found in RA was not encountered in AS and RS although these disease--as well as the other pathologic disorders--are characterized by serum hypergammaglobulinemia. Furthermore, the decreased number of T suppressor cells found in peripheral blood of patients with active RA was not observed in their synovial fluid. Therefore we propose a failure of localization mechanism of T suppressor-cytotoxic lymphocytes in the synovial membrane of RA. Single doses of prednisolone produced a temporary decrease in peripheral blood total lymphocytes, T cells, T helper-inducer cells, and a less marked decrease in T suppressor-cytotoxic cells, in effect, a normalization of the immune balance, characterized by a decreased T helper/T suppressor ratio. In a similar fashion, patients receiving long-term levamisole exhibited a decrease in total lymphocytes, T lymphocytes, T helper cells, and T suppressor cells 6 and 24 hr after drug intake with a subsequent normalization of the OKT4+/OKT8+ ratio. | |
| 4086979 | The classification of subjects with joint complaints on incomplete biochemical and haemato | 1985 Nov | We performed a retrospective study on 163 subjects suffering from rheumatic fever (16), rheumatoid arthritis (36), lupus erythematosus (17), gout (21), arthrosis (50) and osteomyelitis (23). The number of variables evaluated was 39. These were all of a general biochemical and haematological nature. A feature reduction resulted in sixteen variables that matched well with those known from the literature. Linear discriminant analysis yielded poor results in classifying the six disease categories (with 18 variables 61.8%). A reduction to three disease categories improved the classification results remarkably. This, and the excellent discriminating power between patients and the reference group, shows that the selected variables are illustrative only for general clinical pictures, such as infection, and not for the desired differential diagnosis. | |
| 7086023 | Shoulder Subluxation in elderly inpatients. | 1982 Jul | Examination of the plain chest radiographs of 300 patients consecutively admitted to a department of geriatric medicine revealed that 16 patients had subluxation of the shoulder. Subluxation and excursion of the humeral head were measured, and the results were correlated with with the range of movement and the ability to perform the activities of daily living. No significant relationship was found, but there was a tendency toward increased impairment of movement with increased excursion. The causes of shoulder subluxation include rheumatoid arthritis and previous injury, but subluxation may be no more than a reflection of the aging process, lax musculature, or an intrinsic mild abnormality of the joint structure. As it is of little practical significance, treatment should be undertaken only in the presence of troublesome pain. | |
| 6256850 | The effect of fasting on plasma cyclic adenosine-3', 5'-monophosphate in rheumatoid arthri | 1980 | Cyclic adenosine-3', 5'-monophosphate (cAMP) may influence important mechanisms in the inflammatory process, and fasting has been claimed to be clinically beneficial in rheumatoid arthritis (RA). A study was therefore designed to measure the concentrations of plasma cAMP in RA patients not undergoing drug treatment during a control and a fasting period. Twelve female RA patients were hospitalized for two 14-day periods and investigated in a crossover study. Clinical and laboratory variables of inflammatory activity were assessed during both periods. During the control period the concentrations of cAMP in plasma were slightly below the lower normal limit, with no significant change throughout the period. The clinical and laboratory variables of inflammatory activity were unchanged during the same period. In the fasting period, the prefasting level of plasma cAMP was significantly higher than on the corresponding day in the control period. During 7 days of total fasting the plasma cAMP concentrations decreased significantly. The clinical and laboratory variables of inflammatory activity decreased significantly from the start to the end of fasting. High prefasting plasma cAMP concentrations were associated with improvement in clinical inflammatory activity. A decrease in plasma cAMP concentrations during fasting in RA patients is in contrast to the findings in obese and healthy subjects previously reported. | |
| 6603246 | Advances in the radiological assessment of rheumatoid arthritis. | 1983 Aug | Standard radiographic assessment of changes in rheumatoid joints is limited by factors within the radiographic process, i.e. the performance of the X-ray equipment, recording medium and X-ray assessment. The development of microfocal X-ray units overcomes many of the limitations of conventional radiology. The radiographs of high magnification and resolution produced by this system permit early diagnosis and direct quantitative evaluation of disease progress, providing a more effective assessment in therapeutic trials. Advances in other imaging techniques such as computed tomography (CT), nuclear magnetic resonance (NMR) and emission tomography are evaluated in terms of their potential value in assessing disease activity. | |
| 6813481 | The efficacy and safety of auranofin compared to placebo in rheumatoid arthritis. | 1982 Jul | This double-blind multicenter study compares the effect of adding auranofin (AF) 3 mg bid or placebo to patients already taking nonsteroidal antiinflammatory drugs for rheumatoid arthritis. The 242 patients who completed 3 months of therapy demonstrated that the group receiving AF responded better than those receiving placebo. Of the 144 patients who completed 6 months coded medication, the efficacy in the AF group was superior to the placebo group in several parameters including a reduction in the number of painful or swollen joints, grip strength, dropout rate, and global efficacy as judged by the evaluating physician. A significant lowering of the Westergren erythrocyte sedimentation rate and immunoglobulin levels was noted in the AF treated patients. This study includes data summarizing the difference between both groups with respect to on-therapy conditions and toxicity. | |
| 452947 | Follow-up studies of joint complications in yersiniosis. | 1979 | In 1971-73, 60 patients were hospitalized for an infectios disease caused by Y. enterocolitica serotypes III and IX or Y. pseudotuberculosis serotype I. In the spring of 1977 a follow-up study was carried out with 52 of these patients, one patient having died from intestinal perforation evidently resulting from yersiniosis-induced amyloidosis and colitis. The follow-up study showed that two patients had symptoms of sacroilitis, one had developed an apparent rheumatoid arthritis after yersiniosis and one had joint plans and a high serum rheumatoid factor titer with no objective joint changes. All results from kidney and liver studies were normal. No brucellosis antibodies were found in the follow-up study. Twelve patients had antibody titers against Y. enterocolitica serotype III. | |
| 345418 | In vitro mitogen stimulation of synovial fluid lymphocytes from rheumatoid arthritis and j | 1978 | The in vitro responses to mitogens of synovial fluid lymphocytes obtained from eight patients with rheumatoid arthritis (RA) and eight patients with juvenile rheumatoid arthritis (JRA) were studied. The results were compared to the transformation of the patient's peripheral blood lymphocytes stimulated with the same mitogens. Both RA and JRA synovial fluid lymphocytes showed a low transformation to the polyclonal mitogens PHA and PWM with a low ratio PHA-response/PWM-response. The stimulatory effect of purified protein derivative of tuberculin (PPD) was high, whereas a Candida albicans antigen preparation gave a more variable stimulation of the synovial fluid lymphocytes. In some patients the complete mitogen transformation profile of lymphocytes obtained from synovial fluid, synovial tissue and peripheral blood was studied. The results of the synovial fluid and tissue lymphocytes were similar. | |
| 6941367 | Semiopaque arthrography of the temporomandibular joint. | 1980 Dec | Arthrography was performed in 166 temporomandibular joints with known disorders. The results reflected the pathology expected in each disorder. Clicking and locking were characterized by an increased inferior synovial cavity. The superior cavity was either normal or with irregularity of the articular space. In degenerative diseases, the most frequent finding was perforation of the disc. Rheumatoid arthritis was characterized by reduced extent and irregular outline of the synovial cavities. A late effect from contusion of the temporomandibular joint was a slight reduction in the extent of the synovial cavity. Late effects from intracapsular fracture of the mandibular condyle were considerable irregularity of the articular space and perforation of the disc. As a rule, the arthrographs were highly characteristic, and it seems possible to distinguish between the current disorders by means of arthrography. The arthrographs of 15 intact joints are described. The features of unsuccessful arthrography based on 32 instances of extrasynovial injection are described. | |
| 6610912 | Psoriasis and arthritis. I. A population study. | 1984 | In a population survey of 3659 persons aged 20 years or older, no association was found between psoriasis and rheumatoid arthritis. Inflammatory, degenerative and soft tissue rheumatic diseases occurred in 59% of the psoriatics and 46% of the controls. However, the mean number of rheumatological diagnoses in the psoriatics was 1.1 and in the controls 1.3. Features of psoriasis were found in 41 individuals (1.1%). Features of inflammatory arthritis (RA + past-polyarthritis) were established in 5% and 2.2% of the psoriatics and the controls respectively, but this difference is not significant. Because patients with psoriasis have complaints associated with the locomotor system more frequently than non-psoriatic people, it seems likely that the referral rate of the former to special clinics is higher. | |
| 6336891 | Effect of intra-articular orgotein versus a corticosteroid on rheumatoid arthritis of the | 1983 Jan | The effects of intra-articular injections of orgotein (4 mg a week for six weeks) and of methylprednisolone acetate (4 mg a week for six weeks) on the knee joints were compared in a random long-term trial. Twenty-eight patients with active, definitive rheumatoid arthritis were studied by double-blind comparison. The first control examination made after six weeks of therapy showed no differences between the joints treated with orgotein or with steroid. However, at the final control examination after 24 weeks, a disparity between both drug regimens became apparent. Clinical response was evaluated in the knees in terms of cumulative rheumatoid activity index based on morning stiffness, range of flexion, pain scores, and 25-foot walking time. After 24 weeks, orgotein was found to be superior to steroid in the major points of the clinical assessment index but equipotent in marked improvement of the rheumatoid activity index after six weeks of treatment. After intrasynovial orgotein injections, synovial fluid enzyme activity fell significantly, concurrently with reduced prostaglandin E2 formation. Synovial fluid leukocyte counts also decreased, but the percentage of polymorphonuclear cells increased simultaneously only in the orgotein-treated group. The results suggest that patients with rheumatoid arthritis of the knee joints who show good response to orgotein during a short course of treatment are likely to continue their positive response and possibly attain increased relief of symptoms over longer periods of treatment, in contrast to those patients receiving steroids. | |
| 119619 | Monoclonal immunoglobulinaemia in rheumatological practice. | 1979 | Monoclonal immunoglobulinaemia is the manifestation of a number of diseases with a quite different prognosis. In some instances in can be associated with articular symptomatology. The authors present an analysis of case-records of four patients where monoclonal immunoglobulinaemia was associated with signs of rheumatic disease--oligoarthritis or polyarthritis of the rheumatoid type. In one instance Waldenström's macroglobulinaemia with Sjögren's syndrome and hyperviscosity syndrome was involved. In another patient a myeloma was diagnosed. In the remaining two patients a more benign type of monoclonal immunoglobulinaemia was involved. | |
| 470455 | Total joint arthroplasty. The foot. | 1979 Sep | A prosthesis has been designed with which to resurface the painful, degenerated first metatarsophalangeal joint. Clinical evaluation thus far has indicated satisfactory results in 16 of 18 instances. This procedure will probably give the best results in the older patient with hallux rigidus, but the length of follow-up is as yet too short to allow firm opinions to be formed. |