Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 1256690 | [Comparative evaluation of the therapeutic action and tolerance of diftalone and indometha | 1976 Mar 10 | The therapeutic effectiveness and tolerability of diphthalone and indomethacine administered for long periods were compared in 10 patients suffering from rheumatoid arthritis in the active phase. Each patient was treated with one of the two drugs on a double blind basis. Diphthalone proved to be more active than indomethacine on morning stiffness and on hand grip strength. Diphthalone also produced fewer side effects. The differences indicated proved to be significant statistically. | |
| 6309308 | Rheumatoid arthritis simulating other lesions. | 1983 Spring | Radiographs of patients with rheumatoid arthritis can sometimes be misleading. Seven of 69 patients with RA had radiographs sufficiently atypical to lead clinicians to suspect other disorders (e.g., gout, lupus erythematosis, thrombophlebitis). Five of these cases are presented and the diagnosis in each case is discussed. | |
| 48287 | [The morphogenesis of chronic synovitis in rheumatoid arthritis]. | 1975 | The synovial sheath obtained in synovectomy in 35 patients with rheumatic- and rheumatic-visceral forms of rheumatoid arthritis was studied histochemically and immunomorphologically. At early stages of exacerbation of the pathological process in the synovial tissue there were revealed predominantly catabolic processes: an increased permeability of vessels; mucoid oedema; fibrinoid changes in the subintimal layer. Further development of the disease was characterized by predominance of anabolic processes with proliferation of synoviocytes, subintimal histiocytes, productive vasculites, massive lymphoid-plasmocytic infiltration, diffuse, or in the form of lymphoid follicles. Using the immunofluorescent technique the authors revealed luminescence of the rheumatoid factor and gamma=globulin in plasmatic cells, extracellularly, and more rarely in macrophages. Pronounced immunological changes in the synovial sheath in the active course of rheumatoid arthritis were accompanied by a high level of metabolic processes and an intensive phagocytic reaction in synoviocytes and subintimal histiocytes. In observations with a low activity of rheumatoid arthritis the synovial tissue was characterized by low levels of enzymes of oxidative metabolism and hydrolysis, emptying of the capillary bed, processes of sclerosis, hyalinosis, amyloidosis. | |
| 6670258 | [alpha-Interferon indices in systemic lupus erythematosus and the effect of interferon the | 1983 Nov | The effect of interferon inducers of viral and nonviral nature as well as of exogenous leukocyte interferon on interferon response of leukocytes (IRL) was studied in patients with different rheumatic diseases, mostly in patients with systemic lupus erythematosus (SLE). Studies in vitro showed that synthetic polyribonucleotide poly(1) X poly(C) induced in SLE patients on the average 3 times as high IRL indices as the viral interferon inducer Newcastle disease virus. A two-week course of treatment of some SLE patients with exogenous leukocyte interferon in various dosages (10(6), 3 X 10(5), and 10(4) units) resulted in a 2--16-fold increase of IRL values in the majority of the patients. | |
| 7184689 | The elbow. | 1982 Dec | Elbow joint movements have been defined, and published data concerning the measurement of these movements have been reviewed. These measurements may be reproduced by using the techniques which have been recommended, with a choice between straightforward clinical methods or a more pedantic approach for the researcher. It was recognized that the amplitudes of joint movements vary considerably between subjects, and that any lack of motion can best be shown by reference to a normal contralateral limb. Those with bilateral afflictions may have their loss of joint motion assessed by comparison with the average ranges of motion which have been reported. The average ranges of active motion for the adult male are E/F = 0/142 and P/S = 75/80 at wrist, or 65/95 at a hand grip. The average carrying angle is 11 degrees for adult males and 14 degrees for adult females; it averages 6 degrees for children. Data concerning elbow mobility in a rheumatoid population have also been presented. | |
| 3830517 | IgM, IgA and IgG rheumatoid factors in patients with rheumatoid arthritis and normal donor | 1985 Dec | IgM, IgA, and IgG Rheumatoid Factors (RF) were measured by ELISA assay in serum from 26 patients with definite rheumatoid arthritis (RA) and 11 normal controls. IgM-RF was assayed by ELISA, radioimmunoassay, and also by the standard latex fixation test in all sera from RA patients. In patients with RA quantitative amounts of IgM, IgA, and IgG-RF as estimated by ELISA were highly correlated. Significant correlations were found between a physician's rating of disease activity and IgG-RF (r = 0.44; p less than .02) and IgA-RF (r = 0.38; p = .06 but not for IgM-RF as measured in any of the three assays. | |
| 6170972 | [Pleural effusion as the presenting feature of rheumatoid disease. The value of the level | 1981 | The authors report two cases of rheumatoid pleural effusion where the pleural syndrome preceded the joint manifestations. From a clinical standpoint, there was an effusion of moderate volume, pseudo-purulent in one case and straw coloured in the other. Signs of rheumatoid arthritis developed after a period of seven weeks in the first case and after a few days only in the second. Amongst the various characteristics of the pleural fluid which were analysed, the authors noted the value of a fall in glucose level, the lack of specificity of anti-gamma globulin factors, and the diagnostic value of the fall in pleural complement and its fractions. In view of the difficulty in obtaining specific histological proof by pleural biopsy, the reduced complement level is of valuable assistance in the aetiological diagnosis of rheumatoid pleural effusion, exceptional as a presenting feature. | |
| 897585 | Osmic acid in rheumatoid synovitis. A controlled study. | 1977 | In 24 adult RA patients with knee joint synovitis and bilateral hydrops, the worse joint clinically was treated with osmic acid and 50 mg of hydrocortisone acetate, while the better joint clinically was treated with 40 mg of methylprednisolone acetate (Depot Medrol). After 6 months, hydrops was palpable in 8 joints treated with osmic acid and in 15 joints treated with corticosteroid only. Pain relief was more marked in joints treated with osmic acid. | |
| 6666910 | [Rheumatoid polyarthritis with Gougerot-Sjögren's syndrome, pulmonary pseudolymphoma and | 1983 | The authors report a case of the Gougerot-Sjögren syndrome with rheumatoid arthritis, of particular interest because of lymphocytic proliferation. This was initially confined to the broncho-pulmonary tissues with histological appearances of pseudo-lymphoma, a diagnosis supported by clinical regression with immunosuppressive drugs, over a 5 years period. This difficult diagnosis needs histological, biochemical and clinical confirmation and, the very existence of this entity is debatable. The occurrence of a malignant lymphoma of the small intestine in the same patient a few years later is an argument in favour of the hypothesis that the pseudo-lymphoma was an intermediary pre-malignant stage of B-lymphocytic proliferation. | |
| 3884806 | A double blind comparison of piroxicam and enteric coated ASA in rheumatoid arthritis. A C | 1985 Feb | A double blind study compared piroxicam, 20 mg OD to enteric coated acetylsalicylic acid (EC ASA), 3.9-5.2 g daily in divided doses, in 145 patients with rheumatoid arthritis (RA). Both drugs improved the signs and symptoms of RA. Patients showed significantly better compliance with a once daily dosage regimen. Gastrointestinal side effect profiles were similar. The EC ASA group showed a higher frequency of tinnitis and more dropouts, while there were more skin reactions in the piroxicam group. Decreased hemoglobin and hematocrit values were more prevalent in the piroxicam group. Piroxicam proved to be an effective alternative therapy to EC ASA. | |
| 4131277 | The molecular basis of self-association of antibodies to IgG (rheumatoid factors) in rheum | 1974 Feb | The serum and synovial fluid of many patients with rheumatoid arthritis contain immune complexes composed of immunoglobulin G (IgG). In this study such complexes from one patient are shown to be formed by self-association of IgG-antibodies to IgG (IgG-rheumatoid factors), so that each molecule serves as an antibody as well as an antigen. All F(ab')(2) and Fab' fragments derived from these complexes have antibody binding sites for normal IgG. Due to a high association constant in the formation of a cyclic complex by these antibodies, normal IgG is excluded as an antigen. These studies serve as a model for further elucidation of presence of similar immune complexes in the serum and synovial fluid of patients with rheumatoid arthritis. | |
| 7417353 | The benign hypermobile joint syndrome. | 1980 Sep | Benign hypermobility as defined by a modification of the Carter-Wilkinson criteria was found in 31 of 637 healthy blood donors, a prevalence of 5%. No increased prevalence of arthritis/arthralgia or characteristics suggestive of Ehlers-Danlos syndrome other than a possible familial predisposition were found when these 31 hypermobile subjects were compared to an age and sex matched two-for-one control group. Cardiac evaluation by auscultation, electrocardiogram, and echocardiogram showed no increased occurrence of mitral valve prolapse in hypermobile subjects. Thus the benign hypermobile joint syndrome appears to be one extreme of the range of normal joint motion and not a systemic connective tissue disorder. | |
| 6516327 | [Virus-like particles in cultures of rheumatoid synovial cells]. | 1984 Sep | Cultures of synovial cells from 8 patients with classical or determined rheumatoid arthritis and 3 patients with non-rheumatoid arthrosis were examined electron microscopically. Cells of the monolayer formed upon prolonged incubation of tissue pieces had the conventional ultrastructure of synovial cells. In 2 out of 8 cultures of rheumatoid synovial cells after 14 days of incubation, budding virus-like particles with the external diameter of 100-120 nm were observed. Morphologically these particles were very similar to retroviruses. Isolated particles had a buoyant density in sucrose of 1.15-1.17 g/cm3. | |
| 7278075 | [Sydenham's chorea with ocular complication (author's transl)]. | 1981 Jul | Case report on a 39-year-old woman with unilateral quadranopia after Sydenham's chorea. Pathogenesis and symptomatology of chorea in general are described, and other ocular complications mentioned in the literature. | |
| 6651084 | [The psychology of chronic rheumatism patients based on the Rorschach test]. | 1983 Apr | The objective of this research was to try to see if it was possible to find in a population of chronic rheumatickies (a great majority of P.C.E.) some specific psychologie characteristics or constants among these sicks. So we have used Rorschach test. On the based of 19 persons inspected, we have found 84% who present a pathological inhibition and 68% a pathological anxiety. They are datums more strikingness, but we have found others interesting indications. For example: 47% persons presented symptoms of a affectivity no stabilize egocentric and impulsive and had a perturbed thought by their affectives problems. 21% a deficient valuation of reality. We have terminated trying to discuss two others questions from datums collected. | |
| 460845 | Arthroscopy of the wrist and finger joints. | 1979 Jul | Ninety arthroscopies of the wrist and finger joints in 34 clinical cases and two amputated arms were carried out with the number 24 arthroscope. Eighty-four wrist and finger joints of four cadavers and two amputated arms were also dissected for macroscopic observation. Most portions of the interior structures of the wrist and finger joints can be observed by the dorsal approaches. Color photography and punch biopsy are also possible. Some arthroscopic photographs taken with the number 24 arthroscope are illustrated. From these experiences it is concluded that the number 24 arthroscope is a useful diagnostic tool in arthroscopy of the small joints, even though there are still many problems. | |
| 4620372 | [Lineal clinico-pharmacological study of butibufen in rheumatic diseases]. | 1974 Sep | The analgesic and antiinflammatory effects of a new synthetic drug, a derivative of p-alcalonic (Butibufen) was studied in 21 patients with osteoarthritis localced mainly in the hip joint and knees. The parameters used in the study, clinical analytical and radiological were paralleled with a statistical study according to the Student test and show a favorable therapeutic response to the drug with an ample statistical significance. The tolerance levels investigated based on the supposed side effectos of Butibufen show that the incidence of such is very low. | |
| 6762942 | Antibodies to native type I and II collagens detected by an enzyme linked immunosorbent as | 1982 Nov | Anti-native type I and/or type II collagen antibodies measured by an immunoenzymatic immunosorbent assay were found to be present in 22.2% of the rheumatoid arthritis cases studied, 27.5% of systematic lupus erythematosus patients and 28.6% of patients with Overlap Syndrome. These antibodies were not associated with any particular clinical or radiological form of rheumatoid arthritis. Nevertheless, antibodies to native type I and/or type II collagens were associated with seropositive rheumatoid arthritis and antibodies to native type II collagen with rheumatoid arthritis which have antinuclear antibodies. In addition antibodies to native type I collagen were especially present in rheumatoid arthritis with extra-articular symptoms. Antibodies to native collagens disappear or are diminished after corticosteroid treatment. Unlike gold, D-penicillamine or non-steroid anti-inflammatory drugs have no effect on levels of antibodies to native type I and II collagens. | |
| 7041831 | Levamisole in rheumatoid arthritis. Final report on a randomised double-blind study compar | 1982 Apr | The therapeutic effect of a single weekly dose of levamisole in patients with rheumatoid arthritis was compared with placebo for 6 months in a 13-centre double-blind controlled study. 281 patients with classic or definite rheumatoid arthritis and active disease were evaluated. A single weekly dose of 150 mg levamisole was superior to placebo in controlling disease activity. A single weekly dose of 50 mg levamisole had an intermediate effect. Adverse reactions occurred in approximately 40% of the patients with 150 mg levamisole and in approximately 20% of the patients with 50 mg levamisole or placebo. In comparison with the classical dosage schedule of levamisole (150 mg on 3 consecutive days each week) a single weekly dose of 150 mg levamisole was found to be slightly less effective but much better tolerated. | |
| 6367750 | Controlled trial of hydroxychloroquine and D-penicillamine singly and in combination in th | 1984 Mar | A 2-year, controlled, double-blind trial of D-penicillamine and hydroxychloroquine either alone or in combination was conducted on patients with progressive rheumatoid arthritis. The group given D-penicillamine alone improved most, but a linear fall-off in efficacy occurred. Surprisingly, the group receiving combination drug therapy did not fare as well as the group receiving D-penicillamine therapy. A subset of patients receiving hydroxychloroquine therapy had prolonged benefit. Toxicity, though not uncommon, was generally not severe. |