Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 6737375 | Lichenoid lesions of the oral mucosa in rheumatoid arthritis patients treated with penicil | 1984 Jun | Seven of 56 consecutive patients taking penicillamine for rheumatoid arthritis developed oral lesions that clinically and histologically resembled lichen planus. All 7 patients had rashes with prior gold therapy and 4 had rashes with penicillamine therapy. Lesions appeared between 3 and 12 months of therapy at an average dose of 400 mg/day and disappeared within 3 months of stopping the medication. Discontinuation of the drug for oral lichenoid lesions is not necessary. Topical steroids can be used for symptomatic relief. | |
| 7123174 | Platelet function in rheumatoid arthritis. | 1982 | Platelet function tests were evaluated in 20 patients with rheumatoid arthritis (RA), 9 of whom displayed thrombocytosis (greater than 400,000 platelets/microliter). Most patients had an enhanced sensitivity to collagen and epinephrine induced aggregation, as compared with a reference group. In contrast, malondialdehyde (MDA) production, an index of platelet arachidonic acid metabolism, was in the normal range for all the patients except 3, who were LE phenomenon positive. The hypersensitivity of platelets to aggregating stimuli was particularly marked in thrombocytotic patients, who also showed the most striking biochemical and clinical abnormality. These findings indicate the crucial role of platelets in the development and self-sustaining of RA. | |
| 7010272 | [Neutrophil migration in patients with rheumatoid arthritis (author's transl)]. | 1981 Jan | The leukocyte mobilization "in vivo" was assayed in 16 patients with rheumatoid arthritis and 10 normal subjects using the modified Senn's technique. The rate of leukocytes mobilization (LMR) is variable: in 5 cases lower than normal. No correlation is found with latex or Waaler-Rose titer, total complement in the serum, but the lowest rates of leukocyte mobilization are in previously treated patients. After 48 hours of indomethacin treatment, the LMR decreases significantly both in the patients and in the normal subjects. These results show that the abnormal "in vivo" LMR is more related to drug therapy than disease. | |
| 6384266 | Immune function in severe, active rheumatoid arthritis. A relationship between peripheral | 1984 Oct | The immunohistology of synovium from a tender, swollen knee and peripheral blood cellular immune function were correlated in 24 clinically similar patients with active, seropositive rheumatoid arthritis who were not taking cytotoxic or long-acting antirheumatic drugs. The patients were classified as anergic (n = 6) or nonanergic (n = 18) on the basis of peripheral blood mononuclear cell proliferative responses to a battery of soluble recall antigens. The peripheral blood mononuclear cells of anergic patients failed to respond significantly to any soluble recall antigen, whereas cells from nonanergic patients responded to at least one such antigen. Multiple pieces of synovial tissue were obtained from each patient at arthroscopy. To minimize intrajoint variability, all pieces were analyzed and averaged to determine a composite profile of abnormalities. Synovial specimens from all six anergic patients had "high intensity" lymphocytic infiltration (group A). In sharp contrast, synovial specimens from 15 of 18 nonanergic patients had "low intensity" lymphocytic infiltration (group B) (P = 0.002). Group A tissues typically showed higher intensity T cell and plasma cell infiltration, more synovial lining layer hyperplasia, more HLA-DR bearing cells, and a higher ratio of Leu 3A/Leu 2A T cells than did group B. Group B tissues had fewer infiltrating cells (most of which were OKM1 and HLA-DR bearing), more extensive fibrin deposition, and far fewer T and plasma cells. Although these data do not imply that synovium from different joints in an individual patient are immunohistologically identical, they do provide evidence that peripheral blood mononuclear cell immune function reflects immunopathologic events in the biopsied joint. Moreover, the data further support the view that clinically active rheumatoid arthritis is, like certain other chronic inflammatory conditions, a heterogeneous disorder with polar subgroups. | |
| 36289 | Complexed rheumatoid factor measurements in sera, synovial fluids and in immune complex fr | 1979 Mar 15 | Mild acidic treatment increases the rheumatoid factor titre of some sera and synovial fluids (SF) in rheumatoid arthritis (RA), juvenile RA (JRA) and most frequently in rheumatoid vasculitis. This unmasking of 'hidden' RF in serum and SF samples correlated with the RF-immune complexes (RF-IC) and complexed C4 present in the 3% polyethylene glycol (PEG) precipitates, indicating that by means of 'hidden' RF measurements RF-ICs are possibly detected. This method seems to provide a diagnostic tool for detecting RF-ICs in RA and other related diseases. | |
| 4001874 | Correlation of inflammatory RA disease activity with laboratory parameters. | 1985 | Fifty-one patients with rheumatoid arthritis were examined at 6-month intervals during a 2-3-year investigation period. Correlations of an inflammatory activity index calculated from nine criteria with several laboratory parameters were computed. ESR correlated most closely, followed by the IgM concentration of circulating immune complexes, hemoglobin, C3A, and fibrinogen. | |
| 7416929 | Functional Status Index: reliability of a chronic disease evaluation instrument. | 1980 Sep | The reliability of 3 methods of assessing respondents' perceptions of their functional ability was tested. The Functional Status Index defines function as including 3 distinct but related dimensions: the degree of dependence, the degree of difficulty and the amount of pain experienced in performing specific activities of daily living. A total of 149 adults with rheumatoid arthritis were studied. Exploratory factor analyses of scores on 18 specific daily activities across the 3 hypothesized dimensions yielded the following functional categories: gross mobility, hand activities, personal care, home chores and interpersonal activities. The resultant indexes achieve internal consistency reliability levels ranging from 0.66 to 0.91 across all but 1 functional category. Average test-retest and interobserver reliability values range from 0.65 to 0.81. Levels of interobserver reliability generally equal or surpass levels of test-retest reliability. The findings suggest that it is feasible to quantify level of function using self-report methods. The Functional Status Index is recommended for use in investigations where changes in functional ability are of interest. | |
| 114649 | Gold compounds in rheumatoid arthritis: clinical-pharmacokinetic correlates. | 1979 | Currently available techniques do not enable the clinician to identify which patients with rheumatoid arthritis will respond favorably to chrysotherapy or to predict which patients will develop gold-related complications. Gold concentrations are similar in blood, urine, feces, skin, hair and nails in gold-responders and non-responders, and in gold-toxic and non-toxic patients. However, gold toxicity is a function of dosage schedule; higher than conventional doses increase the prevalence and severity of adverse reactions. Preliminary observations suggest that the frequency of common side-effects (e.g. dermatitis, stomatitis, proteinuria) from oral gold (auranofin) is less than that incurred with intramuscular gold prepartions. The possible genetic predisposition to develop gold toxicity is under investigation. | |
| 6467385 | Immunoglobulin G-induced experimental chronic immune synovitis: cell-mediated immunity to | 1984 Sep | In vitro cell-mediated immune responses to homologous rabbit immunoglobulin G (IgG), purified protein derivative (PPD), native Type I, II, and III collagen, and denatured Type I, II, and III collagen were studied in an IgG-induced animal model of immune synovitis. Immune response was measured as augmented [3H]thymidine incorporation by spleen cells on exposure to antigen. Immune responses were observed in vitro after 72 hr of culture with antigen, while a majority of responses to antigens occurred after 96 hr of incubation. Separation of spleen cell subpopulations showed that measured immune responses were of T-cell origin. In vitro cell-mediated immune responses were observed for native and denatured collagen in splenic cell cultures from six of seven synovitic rabbits (P less than 0.01) but not in control spleen cell cultures derived from normal, adjuvant-primed or IgG-immune nonsynovitic rabbits. The incidence of cellular reactivity to incubation with native interstitial collagens was as follows: Type I, 43%; Type II, 43%; Type III, 57%. The incidence of in vitro immune responses to denatured collagens in cultures derived from rabbits with synovitis was: Type I, 50%; Type II, 50%; Type III, 67%. The relatively high incidence of immune response to both native and denatured collagens suggests that immunity to structural components of the synovial membrane and the adjacent surface of articular cartilage may play a role in the inflammation observed in immune synovitis. | |
| 1224805 | [Cytology and histochemistry of synovial cells in various forms of arthritis]. | 1975 Jan | Synovial effusions from various kinds of arthritis have been examined both morphologically and histochemically. These two methods give complementary evidence, and show (i) that there are two fundamentally different types of cell present in rheumatoid arthritis (ii) that the synovial fluid from septic arthritis can clearly be separated from that of all other forms of arthritis and (iii) that intracellular crystals can be demonstrated in gout. Laboratory methods also give information on the polysaccharide and fat content of synovial fluid, in particular on the lipid material in the cell free supernatant. Large mononuclears in the fluid are probably generated in the local tissue and reflect minimal differentiation from a basic cell type. | |
| 2988847 | Short course of synacthen therapy as an adjunct in the management of rheumatoid arthritis. | 1985 Jun | The effect of synthetic adrenocorticotrophic hormone (Synacthen), in conjunction with hydroxychloroquine, aurothioglucose, or penicillamine, was evaluated retrospectively in 21 patients with rheumatoid arthritis (RA). One mg of depo Synacthen was administered at increasing intervals of 4 to 14 days for a total period of 3 to 7 months. Fourteen patients with RA on either hydroxychloroquine or aurothioglucose and not on Synacthen, served as controls. Patients in the Synacthen group were, on the whole, sicker, as indicated by a lower functional capacity, higher mean erythrocyte sedimentation rate, and systemic and articular indices. Physicians' estimate of the patients condition after 1 - 2 months of therapy showed no improvement or deterioration in 10 out of 13 cases in the control group. Likewise, the erythrocyte sedimentation rate decreased significantly more and seronegativity was achieved in more of the Synacthen-treated cases. Six to 8 months after the beginning of therapy (1 to 4 months after cessation of Synacthen) clinical improvement was comparable in both groups, although seroconversion was more common in patients who had received Synacthen (7 out of 10 as compared to 1 out of 7 respectively). It is suggested that Synacthen may be used safely in the early phase of selected RA patients, until the effect of second-line drugs is achieved. | |
| 78711 | Contrasting patterns of newer histocompatibility determinants in patients with rheumatoid | 1978 Jun | The Ia alloantigens as measures of different alleles of loci in the major histocompatibility complex were determined in patients with systemic lupus erythematosus (SLE) or rheumatoid arthritis (RA). The Ia specificities of reagents used were defined by their pattern of reaction with lymphoblastoid lines derived from normal donors homozygous for HLA-D determinants. The reagent specificities included those associated with a single Dw type as well as those reacting with a single specificity shared by several Dw types. Patients with RA had a marked elevation in the frequency of alloantigens detected by reagent sera that recognize various determinants shared by cell lines from HLA-Dw4, Dw7, or Dw10 individuals (Ia 4-7-10). The frequency of mixed lymphocyte culture alleles Dw4 and Dw10 was found to be increased; however this elevation did not approach the higher frequency for the serologically determined antigens of the Ia 4-7-10 group. In contrast, patients with SLE had an increased frequency of reactions with the reagent alloantisera defined by reactions with either HLA-Dw2 or Dw3 positive cell lines. The data suggest that immunogenetic factors are relevant to both groups of patients, but that these are entirely distinct for each disease. | |
| 486055 | [Effects of menopause, pregnancies, breast feeding and hormonal contraceptives on the cour | 1979 | ||
| 3977419 | Common IgA and IgM rheumatoid factor idiotypes in autoimmune diseases. | 1985 Mar | Anti-idiotypic antibodies to four monoclonal IgM, one polyclonal IgM, and one polyclonal IgA rheumatoid factors were produced in rabbits and tested for cross reactivity with rheumatoid factors from nine patients with essential mixed cryoglobulinaemia, three patients with rheumatoid arthritis, four patients with systemic sicca syndrome, and one patient with systemic lupus erythematosus. Variable (3/16 to 10/16) cross reactivity for each anti-idiotypic antibody was observed which was not restricted by disease category, clonality, or isotype of the rheumatoid factor. These findings suggest that rheumatoid factor genes are highly conserved from the germ-line antibody repertoire. | |
| 6975966 | [T and B lymphocyte subpopulations with HLA-DR surface molecules in rheumatoid arthritis, | 1981 Nov | The T and B lymphocyte subpopulations were studied in 46 patients with rheumatoid arthritis using a monoclonal anti I-E/CK antibody produced by cell hybridation. This antibody recognized HLA-DR "cross-reactive" molecules on the lymphocytes it attacked. The percentage of T cells which were HLA-DR positive was not significantly raised. Taking into account the fall in the T lymphocytes seen in the course of rheumatoid arthritis, the proportion of this sub-population does not seem to be altered when taking the overall picture into account. Similarly the B lymphocytes do not seem to be significantly altered. Nevertheless the heterogeneity of the levels found in all the DR positive sub-populations allows us to suppose that rheumatoid arthritis as we recognize it contains immunologically distinct entities. | |
| 525064 | [Comparison between ambulatory or stationary treatment systems for patients with rhematoid | 1979 Sep | The evaluation of a detailed questionaire which was issued to 44 German female rheumatoid arthritis patients (family mothers) who underwent "Kur" treatment courses and a comparable group of Dutch patients who had ambulatory treatment only shows little advantage to the "Kur" system). The "Kur" patients had adjusted somewhat better to their illness and had retained more easily the extra-familial social contacts. In contrast, statistically significant advantages were clearly evident in the Dutch ambulatory treatment programm: 1. Over-all reduction in "feeling ill" 2. Reduced stress in association with the objectively reduced joint mobility 3. Reduced stress in association with pain 4. The support of the patient by immediate family members and other relatives is generally better 5. Better patient support possibilities by family friends 6. Reduced negative effects on family life 7. Reduced disruptive effects in relationships between the patients and their husbands and children 8. Higher degree of satisfaction with physicians and the treatment. IN CONCLUSION: Even if national behavioral differences are taken into consideration, the ambulatory system as practiced in Holland seems to hold significant advantages to the "Kur" system. | |
| 6594080 | Characteristics of spontaneously proliferating mononuclear cells in rheumatoid arthritis. | 1984 Oct | The phenomenon of increased spontaneous incorporation of 3H-thymidine (3H-TdR) into peripheral blood mononuclear cells in rheumatoid arthritis (RA) has been investigated. The activity was found to be short lived and affected less than 1% of cells. Using a Percoll density gradient we identified two populations of active cells. RA patients with active synovitis and increased 3H-TdR incorporation in the low density population of cells have higher overall 3H-TdR incorporation than normal controls and patients with inactive RA. The low density cell population is enriched for Ia+ cells. The data are consistent with raised spontaneous 3H-TdR incorporation being due to an in-vivo cell mediated immune response. | |
| 6774672 | Immunochemical quantitation of complement components of Clq and C3 in sera and synovial fl | 1980 Jun | The amount of the initiating complement component (Clq) in the classical pathway and the first essential component (C3) in the alternative complement pathway were measured with a single radial immunodiffusion (SRID). A high ionic strength was used corresponding to that of 0 . 25 M NaCl and 0 . 01 M EDTA to avoid nonspecific binding of Clq with immune aggregates. Measurements were made on sera and/or synovial fluids from 165 patients with various bone and joint diseases. Values of Clq and C3 in synovial fluids were also expressed as ratios to that of albumin in the same specimens to avoid the influence of differences in volume of synovial fluid in various diseases, and this appeared to provide a reliable index reflecting pathological conditions. Both serum Clq and C3 levels were raised highly in rheumatoid arthritis, gout, and osteomyelitis, but the extent of the elevation of C3 was less conspicuous. Values of Clq and C3 in synovial fluids also markedly increased in rheumatoid arthritis. | |
| 404840 | Lack of measurable complement fixing antibodies against viral antigens. | 1977 Apr | A serological and clinical study was performed to find the common features of 130 patients without antibodies against 11 or more different antigens in the complement fixation (CF) test. These patients (=1.6%) were discovered during hte screening of 8,021 adult patients. Rheumatoid factor(s) (RF) were found in the sera of 113 of the patients. In the remaining 17 patients no common serological or clinical markers were found. Myeloma M-components were found in three cases. The lack of measurable CF antibodies in RF positive cases was apparently due to the inhibitory effect of RF(s) in the CF test. This was indicated by a positive reaction in CF after centrifugal separation of IgM and IgG fractions and also by the detection of antibodies using immunodiffusion method. Possible immune complexes were sought using the platelet aggregation test, which was positive for the sera of 47 (=37%) of the patients. The clinical diagnosis of the 130 CF-nonreactors was rheumatoid arthritis (RA) (ARA criteria) in 23 cases and pulmonary diseases in 65 cases. In a comparison group of equal size there were only 3 RA patients and 15 with pulmonary disease. RA was thus found in 20% of the RF positive CF-nonreacting patients. In the comparison group of 52 RA patients 8 CF-nonreactors were found (=15%). This suggests that the effect of RF(s) from RA patients in CF reaction varies greatly. | |
| 7017915 | Plaque-forming, antibody-dependent, cytotoxic cells with monocytic properties are present | 1981 | Mononuclear cells eluted from synovial tissues from 16 patients with rheumatoid arthritis (RA) and 4 patients with juvenile rheumatoid arthritis (JRA) mediate cytotoxicity in vitro against a monolayer of sheep erythrocytes sensitized with IgG. Cell fractionation experiments suggested that most of the plaque-forming cells were non-lymphocytic and had adherence and phagocytic properties. |