Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 56033 | [Chemotaxis of human polymorphonuclear cells in vitro. Study of inflammatory rheumatic dis | 1975 Dec 13 | Sixty-eight determinations of leukocyte chemotaxis were performed in 42 patients suffering from systemic lupus erythematodes (17 cases), rheumatoid arthritis (15 cases) and scleroderma (10 cases). In contrast to the results of others, this study showed a deficiency in only 15 of 42 cases (35.7%). Impairment of chemotaxis was always transitory and demonstrable only during acute phases of disease. Intrinsic deficiency of PMN leukocytes as well as deficiency of plasma factors were related to the clinical and biological course of the disease and to the treatment. | |
| 2409750 | Plasma total prekallikrein/kallikrein activity in rheumatoid arthritis with and without am | 1985 | Following exposure to kaolin, plasma samples were assayed for total prekallikrein/kallikrein activity in 19 patients with rheumatoid arthritis (RA), 39 patients with RA complicated by amyloidosis, 13 patients with nonamyloid nephropathy and 54 healthy subjects. Increased total kallikrein activity was found in RA patients with amyloidosis and in patients with nonamyloid nephropathy. The concentrations of the plasma kallikrein inhibitors C1-inactivator and alpha 2-macroglobulin were normal in RA patients without amyloidosis, whereas they were increased in patients with amyloidosis as well as in patients with nonamyloid nephropathy. The results suggest that the increased activity of plasma kaolin-stimulated kallikrein in RA patients with amyloidosis is due to the nephropathy per se and probably reflects increased levels of prekallikrein. | |
| 7296967 | Familial interstitial nephritis. | 1981 Sep | Hereditary nephritis is a well recognized disease, but its clinical manifestations and patterns of inheritance are variable. We report a family with hereditary renal disease in which the morphological lesion is interstitial nephritis and the pattern of inheritance autosomal dominant. In contrast with previous reports, microscopic/macroscopic hematuria was not a consistent marker for renal involvement. The family also demonstrates the inheritance of rheumatoid arthritis in an autosomal dominant pattern, not temporally related to the interstitial renal disease. | |
| 272546 | Sjogren's syndrome in SLE: Part I. The frequency of the clinical and subclinical features | 1977 Oct 26 | Clinical features of Sjogren's syndrome were found in 31 percent of 32 patients with SLE. Eight patients had features of KCS while four had xerostomia. Subclinical abnormalities were found in six other patients tested with sialography and labial salivary gland biopsy and there were abnormalities in 65 percent of SLE patients in whom labial salivary gland biopsy was performed. The prevalence of Raynaud's phenomenon and renal disease in SLE patients with and without Sjogren's syndrome were similar but four of the five patients with SLE and an erosive arthritis had symptomatic Sjogren's syndrome. | |
| 6179346 | Inhibited proliferation of human scleroderma skin fibroblasts and rheumatoid synovial cell | 1982 | Griseofulvin at 2-17 micrograms/ml in in vitro inhibited the proliferation of scleroderma skin fibroblasts and rheumatoid synovial cells. The inhibition was concentration-dependent, with little difference between the two types of cells. Mean ID50 values from the four strains of each group were 9.2 for fibroblasts and 9.5 for synovial cells. The results show that griseofulvin at therapeutic concentrations can have a direct effect on the growth of cells cultured from diseased human connective tissues. | |
| 981992 | Chloroquine retinopathy in patients with rheumatoid arthritis. | 1976 | 270 consecutive patients with rheumatoid arthritis who had received chloroquine therapy were examined ophthalmologically for toxic retinal lesions. The total annual dose of chloroquine was 70-75 g. The maximum total dose given was 1330 g. The duration of treatment ranged up to 15 years. The primary material was divided into four groups according to total chloroquine dose received: greater than 100 g, 101-300 g, 301-600 g, and less than 600 g. Each dose group was arbitrarily split into two age groups, one with patients under 63 years of age and the other with patients over 63, in order to analyse the effect of age upon the ocular findings. In the present study, slight macular changes were included in the concept of maculopathy and were not thought to contra-indicate chloroquine therapy. Macular changes were found in about 25% of the patients, regardless of age in the lowest dosage group. The frequency of maculopathy increased with increasing total dose only in the older age group. It was also shown that the frequency of maculopathies and other eye diseases also increased with increasing age. This was evident even from the age of 50. The only patient with chloroquine retinopathy was an inadequately controlled 74-year-old woman. Chloroquine treatment of rheumatoid arthritis in the absence of any other disease which may cause retinopathy implies negligible risks in adult patients under 50 years of age. These patients could be less frequently checked. Older patients require regular ophthalmological checks. It is important to use the smallest effective dose possible, and never higher than 4 mg of chloroquine phosphate/kg body weight and day for 10 months annually; in elderly patients, preferably even lower doses. | |
| 7013719 | Significance of fibronectin in rheumatoid arthritis and osteoarthrosis. | 1981 Apr | Fibronectin is a glycoprotein secreted by connective tissue cells into their environment and into the blood. Plasma fibronectin has been isolated and used to prepare an antiserum. This has been shown to be specific for fibronectin and unreactive with fibrin(ogen) and collagen, to which fibronectin binds in vitro. The antiserum has been used to examine the distribution of this protein in the synovium in health, in rheumatoid arthritis, and in osteoarthrosis, and to estimate levels in plasma and synovial fluid. The results suggest that fibronectin is synthesised by synovial cells, and the synovial fluid level of fibronectin was found to be about twice the plasma level in rheumatoid arthritis. In long-standing arthritis fibronectin was also found to be codistributed with (presumably by adsorption upon) fibrin and immature collagen in intra-articular structures but was no longer demonstrable in areas where mature collagen had been formed in areas undergoing fibrosis. The possible significance of local fibronectin production within joints in relation to its possible effect on the resolution or continuance of arthritis is discussed. | |
| 6188208 | The elimination of alpha 2-macroglobulin complexes from the arthritic joint. A clinical st | 1982 | A phagocytic uptake of labeled elastase-alpha 2-macroglobulin complexes by macrophage-like synovial lining cells was demonstrated in rheumatoid arthritics. The appearance and distribution of these phagocytically active cells were similar to those containing immunoreactive alpha 2-macroglobulin. It was concluded that these deposits represented phagocytosed alpha 2-macroglobulin complexes and that the elimination of complexes from the arthritic joint at least partly was effected via local phagocytosis. | |
| 712480 | Carpal-tarsal osteolysis. | 1978 Nov | A mother-daughter kindred with carpal-tarsal osteolysis and evidence of renal involvement is presented. There was a similarity between the early clinical manifestations of this syndrome and those of rheumatoid arthritis. The distinction made in previous reports between the dominantly inherited form and the sporadic form with nephropathy is questioned. | |
| 118603 | [Reactions against sodium-auro-thiomalate in the treatment of rheumatoid arthritis]. | 1979 Sep | The authors report the case of a 58 year old female patient with rheumatoid arthritis. About 4 hours after each intramuscular injection of Myochrysin (Sodium-auro-thiomalate 5%) she showed undesired reactions such as sialorrhea, nausea, vomiting, abdominal pain, diarrhea, apathy, weakness, head ache, breast swelling, perspiration, feeling of incident death. The following day these symptoms declined, the joint pain, however, increased. The reaction recurred with each of the 5 Sodium-auro-thiomalate injections, but not after injections of 5% Solganal (Aurothioglucose). It is supposed that these side effects are connected with the quick absorption of the Sodium-auro-thiomalate in aqueous solution. The Aurothioglucose in oil suspension would not cause such reactions after an intramuscular injection because of its slower absorption. | |
| 941795 | Ambivalent role of copper in inflammatory disorders. | 1976 Feb | Soluble copper (Cu) preparations are both acute/chronic irritants and effective anti-inflammatory agents in rats. Copper is a prevalent component in several folk remedies for arthritis. Patients with rheumatoid arthritis and ankylosing spondylitis are reported to have higher-than-normal levels of serum copper, mainly associated with albumin. The anti-arthritis drug, D-penicillamine (Pn), efficiently strips Cu from some of its (pharmacologically inert) storage forms, e.g. Cu-albumin, Cu-polynucleotides yielding low M.W. Cu-Pn complexes, which show anti-inflammatory activity (ca. 5 X phenylbutazone) in rats irritated with carrageenan, oleyl alcohol, sodium urate and adjuvants. Under certain conditions Pn also blocks the amine-oxidase activity of caeruloplasmin, a circulating copper protein which is elevated in inflamed animals (an 'acute phase reactant'). Drugs, nutritional factors and the disease process may all possibly affect the movement of copper in vivo between inert reversible pharmacoactive reversible toxic forms. | |
| 1081732 | Study of the effects of antigammaglobulin factors on lymphocytes from patients with rheuma | 1975 | Previous work suggests that peripheral blood lymphocytes from patients with rheumatoid arthritis have altered reactivity. The purpose of this study has been to observe the behavior of cultures of lymphocytes from patients with rheumatoid arthritis when stimulated with autologous 19S rheumatoid factor and with rabbit serum against autologous IgG fraction. The peripheral blood lymphocytes (PBL) from 15 patients with classical rheumatoid arthritis were obtained by passage of the leukocyte-rich plasma through a polyamide fiber column. The purified lymphocytes were cultured with rheumatoid factor obtained from the same donor through Sephadex G-200 chromatography. In another set of experiments rheumatoid lymphocytes were stimulated with rabbit serum containing antibodies against the IgG fraction of the same patient obtained through DEAE chromatography. After five days the lymphocytes were examined for large cells plus cells in mitosis. A positive response was defined as an increase of 5% or more in the experimental tubes when compared with the cells cultured alone. Ten healthy normal subjects were used also as lymphocyte and serum donors. These lymphocytes were cultured alone and with rabbit serum, anti-autologous IgG. 80% of rheumatoid lymphocytes responded with an average of 37% of enlarging and dividing cells when stimulated by autologous RF. The same pannel of lymphocytes responded only with an average of 14% stimulation when cultured with rabbit serum anti-autologous IgG. The response to the 7S antigammaglobulin factor from rabbit in 7 normal PBL was similar to that of rheumatoid lymphocytes. There was some relation between activity of the RA and lymphocyte response to RF and rabbit antiserum. These results could explain the lymphoid infiltration and hyperplasia of patients with RA and, on the other hand, would support the idea that entrapment of RF by leukocytes ('RA cell') would be a protective mechanism. | |
| 6272242 | Circadian placebo and ACTH effects on urinary cortisol in arthritics. | 1980 Winter | The effect of placebo and ACTH-1-17 (Synchrodyn, Hoechst) upon urinary free cortisol was examined at 5 different circadian stages on 10 men with Steinbrocker Stage II-III rheumatoid arthritis. A mean cosinor analysis of urinary cortisol data from the subjects prior to treatment with either ACTH or placebo revealed a statistically highly-significant rhythm. A circadian variation in a response of urinary free cortisol to a placebo was also seen. Moreover, the response of the midline-estimating statistic of rhythm (rhythm-adjusted circadian average) of urinary free cortisol to ACTH-1-17 by patients with rheumatoid arthritis is circadian rhythmic. This reactivity rhythm is out of phase with the spontaneous rhythm in urinary cortisol acrophases-in the tests limited thus far to midsummer. The further assessment of the circadian component in the context of broader interactions by rhythms with other frequencies in various conditions in health and disease is warranted by the demonstration of rhythms here presented for men with rheumatoid arthritis. | |
| 329398 | [Diagnostic value of synovial membrane immunofluorescence]. | 1977 May | The immunofluorescent study of 93 synovial membranes of persons suffering from various types of arthropathy has shown that the only element sufficiently specific to have real diagnostic value is the presence of cells with a fluorescent cytoplasm. This appearance was in fact found in 63% of the cases of rheumatoid arthritis, irrespective of their being either seropositive or seronegative, in 69% of the cases of probable rheumatoid arthritis, in only 15% of the unclassified cases of arthritis, in 28% of the cases of various types of arthritis (20% with exclusion of a case of mixed connectivitis and of a case of Waldenström's macroglobulinemia with rheumatoid arthritis) and in 0% of the cases of mechanical arthropathy. The results of immunofluorescent examination compare favorably with those of standard histology: the classical histologic appearance of rheumatoid synovitis with a node-forming tendency of the infiltrate was observed in only 36% of the verified cases of rheumatoid arthritis, while immunofluorescence was positive in 63% of the cases in this group. In the category of unclassified arthritis, these percentages were comparable, viz. 19% and 20%, repectively. The presence of cells with fluorescent cytoplasm during immunofluorescent examination of the synovial membrane may be regarded as an additional criterion supporting the diagnosis of rheumatoid arthritis. | |
| 1261117 | Intra-articular rheumatoid nodule of the knee joint. | 1976 Jan | A 44-year-old woman with a long-standing history of classical rheumatoid arthritis had an intra-articular rheumatoid nodule of the knee joint. The history, symptoms, and signs of this case were, however, almost identical to those cases previously reported. This entity has a classic presentation and distinct findings on examination which distinguish it from other intra-articular lesions of the knee. | |
| 7234305 | Laser-nephelometric detection of soluble immune complexes. | 1980 | A new method for the detection of soluble immune complexes has been worked out by combining the polyethylene glycol (PEG) precipitation method with laser nephelometry. Experiences achieved by measurements on in vitro immune complexes are presented. The method was found suitable for the detection of immune complexes development in vivo. The optimum concentration of PEG was found to be 3.51%. Results were compared to those achieved by the traditional PEG precipitation technique in 88 cases. The laser nephelometric method was found to be more sensitive and is recommended for use in clinical laboratories. | |
| 6712066 | Spontaneous remission of glaucoma in scleromalacia perforans: a case report. | 1984 Mar | Spontaneous resolution of glaucoma in a patient with scleromalacia perforans is described. Fluorophotometric measurements established the presence of normal aqueous production. The reduced intraocular pressure is ascribed to either autolysis of the trabecular meshwork and/or maximization of the uveoscleral pathway. | |
| 507740 | Arthrodesis in failed knee replacement in eight rheumatoid patients. | 1979 | The series of eight rheumatoid patients is presented in whom arthrodesis of the knee had been performed after a failed knee replacement. Compression arthrodesis was used as a salvage procedure. The fusion rate was 75% (6/8 knees). In two patients arthrodesis was attempted three times before fusion occurred. The causes of failure are discussed. The compression technique of Charnley or Hoffman is recommended but with two frames. When the arthrodeses were properly fixed fusion seemed to occur in 2-3 months. | |
| 725465 | [Study of 70 cases of rheumatoid polyarthritis treated by pyrithioxin with a 1-year follow | 1978 Jul | The authors present their own series of 70 rheumatoidpolyarthritis cases treated with pyrithioxine during one year or more except in the case of failure or intolerance. The following results were observed after one year: 54 percent showed positive results, 34 percent showed no results or dubious ones, and there was 13 percent of discontinuance because of intolerance. Modifications of the posology and methods of administering are proposed, and the role of pyrithioxine, as a basic treatment for rheumatoid polyarthritis, is discussed. | |
| 2858182 | Sulphasalazine: a safe, effective agent for prolonged control of rheumatoid arthritis. A c | 1985 Mar | The place of sulphasalazine in the management of rheumatoid arthritis over prolonged periods of time has been compared and contrasted with that of sodium aurothiomalate. One hundred and forty-three patients (59 on sulphasalazine, 84 on sodium aurothiomalate) have been treated for periods of up to 42 months. Sulphasalazine is highly effective for some patients, though probably less frequently than sodium aurothiomalate. However, its safety profile is far superior, and very long-term treatment with sulphasalazine is a safe option for treatment of rheumatoid arthritis. |