Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 6094669 | The production of human monoclonal autoantibodies from patients with rheumatoid arthritis | 1984 Nov 30 | Rheumatoid lymphocytes tend to transform 'spontaneously' in vitro because of prior infection with Epstein Barr virus (EBV). They are particularly difficult to use in experiments involving cell hybridisation, because in the conventional half-HAT system unfused transformed cells may be confused with hybrids. We describe how the HAT-sensitive, ouabain-resistant human B lymphoblastoid cell line KR4, originally developed to 'rescue' EBV induced B cell clones, can be fused successfully with peripheral blood lymphocytes from patients with rheumatoid arthritis to produce unequivocal hybrids. | |
| 107725 | Precipitation of streptococcal peptidoglycan by human sera: influence of anti-immunoglobul | 1979 Feb | Antibodies to streptococcal peptidoglycan (PG) were detected by gel-precipitation in 38% of sera from blood donors and in 71% of sera with a Waaler-Rose test titre of greater than or equal to 1:64. Twenty-six rheumatoid arthritis sera revealed patterns of interference with complete or partial fusion between PG and aggregated human IgG while none of the sera precipitating both these preparations showed non-interference. The reactions were interpreted as denoting interference between the PG-antibody complexes and aggregated IgG. Conversion of some non-precipitating blood donor sera to PG precipitation was obtained by addition of isolated rheumatoid factor, in itself not precipitating PG, to the sera. Thus, the high frequency of PG precipitation among rheumatoid arthritis sera could--at least in part--be attributed to the participation of anti-IgG in the reaction. | |
| 6602506 | Femoral neck erosions: sign of hip joint synovial disease. | 1983 Jul | Pathologic synovial processes in the hip joint can cause characteristic extrinsic erosions of the femoral neck, which in extreme cases produce an "apple core" appearance. Nine such cases of synovial diseases, including synovial osteochondromatosis, pigmented villonodular synovitis, rheumatoid arthritis, and amyloidosis, that demonstrate this radiographic finding are presented. The anatomic relations of the hip joint that result in this appearance, differential diagnosis, and radiographic techniques useful in diagnosis are discussed. | |
| 6484447 | The clearance of heat-damaged erythrocytes by the reticulo-endothelial system in systemic | 1984 | Reticulo-endothelial function was assessed in 20 patients with active rheumatoid arthritis and 11 patients with systemic lupus erythematosus with regard to the clearance of heat-damaged erythrocytes (HDE). In contrast to previous reports, no correlations were found between disease activity, levels of circulating immune complexes and splenic function. There was no evidence of an obvious hypofunction in the reticulo-endothelial system of the spleen in patients with rheumatoid arthritis or systemic lupus erythematosus. Moreover, a splenic hyperfunction is suggested to be present in some patients. A method for measuring the specific uptake by the liver, spleen and the clearance rate (T 1/2) of the HDE is also described. | |
| 3878569 | [Antiplatelet antibodies of the IgM class detected by ELISA in the serum of 20 patients wi | 1985 Nov | In an earlier study, the authors demonstrated IgM anti-B lymphocyte antibodies in the sera of patients with rheumatoid arthritis. In an attempt to identify the target antigen, we studied the reactivity of these same sera to other cells, by means of a recently developed ELISA micro-method. 7 of the 20 sera contained IgM anti-platelet antibodies. There is an inverse correlation between the presence of anti-platelet antibodies and anti-B lymphocytes antibodies. The detection of anti-platelet antibodies in the serum of patients with rheumatoid arthritis may correspond to the recognition of aggregated immunoglobulins or specific immune complexes bound to receptors on the surface of the platelets. | |
| 6410605 | [A non-steroidal antirheumatic agent (nabumetone): effectiveness and tolerance in short an | 1983 Mar | Nabumetone, a new nonsteroidal antirheumatic drug (NSAD), is chemically a (6-methoxy-2-naphthyl) butan-2-on. This drug was investigated with regard to its effectiveness and tolerability in an open multicenter study of 3 weeks duration, involving 40 patients with osteo-arthrosis and 45 with rheumatoid arthritis. 11 patients with arthrosis of the hip and 8 suffering from rheumatoid arthritis were continuously treated 6-12 months. The evaluation showed a good result in 85% of the patients with osteo-arthrosis and in 80% of the rheumatoid patients therapy of 3 weeks. Side effects were comparable with those of other NSADs. The changes in laboratory findings were not clinically significant. During long-term therapy both good tolerability and persisting efficacy were evidenced. | |
| 6861373 | IgA and IgM rheumatoid factors in serum, saliva and other secretions: relationship to immu | 1983 Apr | Paired serum and saliva samples from seven patients with systemic sicca syndrome (SSS), 15 patients with rheumatoid arthritis and a positive Schirmer's test (RA+), 15 patients with rheumatoid arthritis and negative Schirmer's test (RA-) and 14 normal individuals were analysed for albumin and immunoglobulin concentration as well as IgA and IgM rheumatoid factor (RF) activity. Protein levels in saliva were higher in SSS and RA+ but, when corrected for serum concentration and salivary flow rate, only the IgG ratio remained significantly elevated in SSS (P less than 0.01) and RA- (P less than 0.05) and the IgM ratio was reduced in RA- (P less than 0.05) compared to controls. Although IgM RF activity in serum and saliva was strongly correlated (P less than 0.001) in all three patient groups, the activity in saliva was considerably lower than serum activity. In the two (RA) patients tested, IgM RF in saliva contained secretory component. Mean salivary IgA RF activity varied between 34% (RA-) and 84% (SSS) of serum activity and correlated with serum activity in SSS (P less than 0.001) and RA- (P less than 0.01). IgA RFs in saliva, but not in serum, contained secretory component. Additional demonstration of IgA RF activity in nasal and duodenal secretions in SSS may be related to involvement of the common mucosal immune system. | |
| 7361058 | [The rheumatoid foot. Origin of deformations]. | 1980 Feb | Deformations of the foot are a logical and predictable function of the biomechanics of the foot and the constraints undergone by the articulations of the foot, that are unstabilized by the inflammatory process. They result from the combination of three factors : anevolutive teno-articular synovitis, predictible forces (the weight of the extrinsic muscle, the anti-physiological foot), and the congenital morphotype of the foot. Typical deformations (peroneal " coup de vent " of the toes, triangular metatarsus), differ on the clinical level in keeping with the morphotype but respond to the same mechanism. The " coup de vent peronier " remains the most characteristic deformation and is furthered by the excentric action of the extrinsic muscles, and in particular the foot muscle. The common denomination of deformations of the back part of the foot is represented by the valgus calcanean, linked to the action of the weight on the orsion forces that is more or less modified. A better knowledge of the cause of these deformations would make it possible to avoid, if not their apparition, at least their worsening. | |
| 6530349 | Inhibitory effect of sera from rheumatoid arthritis patients and enhancing effect of levam | 1984 | We determined the E-rosette levels (E-R) in rheumatoid arthritis patients (RA) and repeatedly tested a selected group with depressed E-R. We also evaluated, in vitro, the inhibitory effect of RA sera on normal E-R and the enhancing effect of levamisole (LV) on normal and RA E-R. Selection criteria and E-R protocol were those of Di Perri (1979). Mononuclear cells (MNC) from 23 normal donors had a mean E-R of 53 +/- 7% (X +/- SD) and this was unchanged after incubation with 32 microM LV. MNC from 31 RA displayed a value of 42 +/- 7% which was lower (p = 0.01) than the normal values and which increased to 47 +/- 9% after LV treatment (p = 0.02). Twenty of these RA did not show enhanced E-R after LV; the remaining 11 RA had E-R of 37 +/- 6% which were restored to 50 +/- 8% after incubation with LV (p = 0.001). We defined this latter group of RA as depressed responders (DR). Four DR were tested repeatedly over a four-month period and consistently remained depressed. Their sera had inhibitory activity on E-R of healthy donors. In vitro treatment of healthy MNC with these RA sera plus 3.2 microns LV abrogated the inhibitory effect. Both the IgG and the IgM fractions of the RA sera manifested this inhibitory effect. We conclude that RA can have depressed E-R which are not transient and can be corrected by in vitro incubation with an immunomodulator. Sera from these RA can inhibit E-R of normal MNC, and LV can abrogate the inhibitory activity of such sera. | |
| 188157 | [Spontaneous septic arthritis in disseminated lupus erythematosus]. | 1976 Apr 9 | The authors report the case of a young 17 year-old girl with acute systemic lupus erythematosus who presented with purulent arthritis due to Group A hemolytic streptococcus in the knee, and perhaps other joints. She had not yet received any treatment. The purulent arthritis was cured by antibiotics. In spite of corticosteroids and immuno-suppressive agents (Chlorambucil), the patient died one year later. Spontaneous purulent arthritis is rare during systemic lupus erythematosus. We found only 8 other cases in the world literature. Contrary to our case, these were patients already treated with corticosteroid or immuno-suppressive agents. In our patient, the absence of previous treatment permitted us to incriminate the lupus itself in the onset of this infection. The conditions of onset of infection during lupus erythematosus are discussed. | |
| 6328467 | Serum angiotensin converting enzyme in Sjogren's syndrome--a case report and study of 21 f | 1984 Apr | We report the case of an elderly woman with primary Sjogren's syndrome and abnormal liver function tests indicative of primary biliary cirrhosis. She was found to have a raised serum angiotensin converting enzyme activity. We proceeded to study 21 further cases of Sjogren's syndrome to discover whether raised levels of this enzyme were a feature of Sjogren's syndrome. None of them had any features to suggested associated primary biliary cirrhosis. The cases included 12 with associated rheumatoid arthritis, two with systemic sclerosis, three with systemic lupus erythematosus and four with primary Sjogren's syndrome. In only two of these 21 patients was a raised serum angiotensin converting enzyme obtained, the elevation being modest. We conclude that a raised activity of the enzyme is not usually associated with primary or secondary Sjogren's syndrome, and that discovery of such an abnormality should prompt a search for an associated condition. | |
| 6611575 | Evidence for relationships between antiperinuclear and IgG rheumatoid factor. | 1984 | Antiperinuclear factor (APF) and IgG-rheumatoid factor (IgG-RF) has been found in 64% and 48% of cases of rheumatoid arthritis, 36% and 50% of cases of psoriasis and 31% and 45% of cases of primary Sjögren's syndrome. A close relationship between APF and IgG-RF is suggested by statistical and experimental data. Purified IgG-RF has some degree of APF activity. | |
| 7226648 | Secondary operations after knee joint replacement. | 1981 May | In 254 knee joint arthroplasties performed during the period between 1972 and 1977, secondary operations were done in 31 knee joints, a frequency of 12%. In the rheumatoid group the frequency was 6%, in those with osteoarthritis, 18%. Loosening was the indication for reoperation in 14 cases and infection in seven. Hinge prostheses required reoperations more often than the other types (Geomedic, St. Georg). Obesity and a previous operation on the same knee increased the risk of complication leading to reoperation. Reoperation involved exchange of prosthesis in 17 patients, arthrodeses in three, irrigation drain in three, femur amputation in one, and minor intervention in the remaining seven. The results of the reoperations were classified as good in 13 cases, fair in 12 and bad in six. | |
| 6602676 | IgG rheumatoid factors and anti-nuclear antibodies in rheumatoid vasculitis. | 1983 May | We studied the distribution and characteristics of circulating rheumatoid factors (RF) and anti-nuclear antibodies (ANA) in 30 rheumatoid arthritis (RA) patients who had polyarthritis alone (group I), 28 RA patients with polyarthritis and extra-articular disease (group II), 28 RA patients with systemic vasculitis (group III) and 60 healthy matched controls. IgG RF occurred more frequently and in higher serum titres in group III (100%) than RA patients in group I (40%), or in group II (18%) or in normal controls (5.8%). The serum titre of IgM RF was higher in vasculitis patients than in other RA patients. ANA were found in 74% of all RA patients and although the frequency did not differ in the three patient groups, the serum titre was significantly higher in the vasculitis group. Antibodies to extractable nuclear antigen were found only in group III (18.7%). Antibodies to histones were also more prevalent in group III than in the other RA groups. The serological abnormalities in rheumatoid vasculitis differed quantitatively as well as qualitatively from other RA patients. | |
| 6430517 | Functional adaptation of the human locomotor system to normal and abnormal loading pattern | 1984 | The adaptation of bone to its mechanical environment can be understood only in the context of its relationships to the soft tissues of the locomotor system, and its dual requirements to provide structural support and preserve articular cartilage. Radiographic analysis of the human skeleton provides insights into the nature of load transmission. Bone's adaptation to abnormal situations such as arthritis, or total joint implants, provides information about the limits of its tolerance to altered load or strain patterns. Knowledge gained from analysis of the first 20 years of total joint arthroplasty should provide prostheses of improved design and materials in the future. | |
| 4081106 | Direct magnification radiography in pediatric radiology. | 1985 Apr | Some indications in which direct magnification radiography might be useful in the diagnosis of newborns and infants are illustrated. We believe direct magnification radiography is useful especially in respiratory distress syndrome, suspected aspiration of amniotic fluid and meconium, suspected pneumonia, mediastinal pathology, in newborns and infants and metabolic and inflammatory diseases of the skeletal system in older children. | |
| 7114915 | Frequency of chondrocalcinosis of the knees in asymptomatic hyperuricaemia and rheumatoid | 1982 Aug | An association has been reported between urate gout and chondrocalcinosis. Chondrocalcinosis was detected in knee radiographs of 8 of 138 gouty patients compared with none of 142 age matched nongouty normouricaemic controls (p less than 0.025). To define this association further, knee radiographs were examined of 84 patients with asymptomatic hyperuricaemia who had been carefully age matched with the gouty and control groups. Chondrocalcinosis of the knees was detected in only one patient, the difference from the control group not being significant. It therefore appears that there is an association of chondrocalcinosis with gouty arthritis, but not with asymptomatic hyperuricaemia. An association between chondrocalcinosis and rheumatoid arthritis has been suggested, but the studies were not controlled for age. To re-examine this implied association, knee radiographs were inspected of 127 patients with rheumatoid arthritis who had been age matched with the control group. Chondrocalcinosis of the knees was detected in only one patient, a difference from the control group which is not statistically significant. | |
| 3878875 | Circulating immune complexes and rheumatoid arthritis. | 1985 Oct | Circulating immune complexes (CIC), as detected by the Clq binding assay (ClqBA) in sera from patients with rheumatoid arthritis (RA) were not demonstrable on analysis by ultracentrifugation on sucrose gradients. This discrepancy could be explained by the finding that polyethylene glycol 6000(PEG), used in the ClqBA to separate free radiolabelled Clq from complex bound Clq, increased the avidity of rheumatoid factor (RF), resulting in the formation of Clq binding RF IgM IgG complexes. Addition of purified RF IgM to normal human serum generated a positive ClqBA in a dose dependent way. The increased complex formation between RF IgM and IgG by PEG was also demonstrated in an enzyme linked immunoabsorbent assay and with sucrose gradients, where complexes became detectable when PEG was present. On the other hand RF IgM IgG Clq complexes obtained from the ClqBA dissociated upon removal of PEG. We conclude that high amounts of immune complexes, detected in RA sera by the ClqBA, are at least partly the result of in vitro complex formation between RF IgM and IgG. Therefore the results of this assay do not reflect the situation in the circulation in vivo. | |
| 3907841 | Future trends in surgical management of joint diseases. | 1985 | The development of artificial joints has made it possible for many victims of joint destruction to lead normal lives. However, a number of problems have limited the proportion of patients that might benefit from prostheses. The author discusses developments that could overcome many of the obstacles and make the benefits of reconstructive surgery available to a larger population. | |
| 4521198 | The effect of aspirin on sickling and oxygen affinity of erythrocytes. | 1973 Dec | The recent suggestion that the administration of aspirin might be useful in the treatment of sickle-cell anemia has been further studied and found to be without basis. After incubation with aspirin, sickle-cell erythrocytes are not inhibited from sickling after deoxygenation. In addition, although aspirin does transfer the acetyl group to hemoglobin both in vitro and in vivo, in our experiments the reaction does not result in any alteration in the oxygen equilibrium of either intact erythrocytes or hemoglobin in solution. Furthermore, patients maintained on long-term aspirin administration also showed no shift in the oxygen affinity of their blood. |