Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 796645 | Comparison of effectiveness of mefenamic acid and ibuprofen in treatment of rheumatoid art | 1976 Nov 27 | This paper reports a double-blind crossover trial comparing mefenamic acid (1500 mg/day) with ibuprofen (1200 mg/day) in the treatment of patients with rheumatoid arthritis receiving maintenance salicylate therapy. Both drugs were used in three divided doses. Mefenamic acid compared favourably with ibuprofen. In the adopted dose regimes the side effects from both drugs were mild and almost exclusively gastrointestinal. | |
| 6494778 | [Plasma and synovial fibronectin. Results of personal research]. | 1984 Jul | The authors report the results of an assay of plasma fibronectin and synovial fluid fibronectin conducted in 104 patients with arthropathy, including 26 cases of rheumatoid arthritis, 43 cases of mechanical arthropathy and 35 cases of non-rheumatoid arthritis. The plasma fibronectin levels do not vary significantly between the different groups of patients, but the mean value for the whole group of patients is significantly lower than that of a control population. The mean value of synovial fluid fibronectin was significantly higher in the patients with rheumatoid arthritis (583 +/- 76 mg/1) than in the patients with non-rheumatoid arthritis (379 +/- 58 mg/1) or mechanical arthropathy (367 +/- 32 mg/1). The assay of synovial fibronectin could therefore provide useful information for the aetiological diagnosis of inflammatory arthropathies. The local origin, from the synovial membrane itself, of the fibronectin in the synovial fluid is suggested by the fact that the synovial concentration of this protein is superior to the serum concentration in 50 to 90 per cent of cases, depending on the disease. | |
| 4032405 | Aspirin dosing using 15 grain enteric coated tablets. | 1985 Apr | A high unit dose (15 grain/975 mg) enteric coated aspirin preparation was studied in normal individuals and patients with arthritis to determine how readily well tolerated, therapeutic (150-300 micrograms/ml) salicylate (SA) levels could be achieved using a twice daily dosing regimen. Of 36 participants enrolled, 33 (92%) achieved this goal (mean SA = 224 micrograms/ml), while in the remaining 3 an initially toxic level fell below the therapeutic range after reducing the dose by one tablet/day. Although the relationship between dose (mg/kg) and steady state SA levels was roughly linear (r = 0.74), in some subjects there was a striking incremental change in the SA level when the dose was adjusted. Over 90% of subjects taking a starting dose between 45-60 mg/kg/day achieved a therapeutic level. Thus, antiinflammatory therapy using 15 grain/975 mg enteric coated aspirin given twice daily appears to be feasible. | |
| 781228 | Fenoprofen in patients with rheumatoid arthritis receiving maintenance gold therapy. | 1976 | Thirty patients with active definite or classic rheumatoid arthritis (RA), participated in a double-blind crossover study comparing fenoprofen calcium with placebo. All patients were receiving maintenance gold therapy. Fenoprofen was administered in doses ranging from 200 to 800 mg every six hours. The median daily dose was 1.8 gm. During this 16-week trial, most parameters of efficacy showed fenoprofen to be significantly more effective than placebo. Adverse reactions, which were minimal, suggest that fenoprofen will be useful in the management of patients with RA, particularly in those with gastrointestinal intolerance to the usually employed drugs. The longterm effectiveness in RA, and the side effects associated with chronic administration remain to be assessed. | |
| 7133972 | [Treatment of rheumatoid arthritis with pirprofen. Comparison of 2 dosage regimens]. | 1982 Aug 28 | One hundred ninety-five patients suffering from active rheumatoid arthritis were included in a two-week double blind multicentric study, whose purpose was to compare the efficacy and tolerance of a daily dose of 600 mg of pirprofen to that of 1200 mg and the placebo. The results show that there is a dose-effect relationship of definite clinical interest. Thus, the investigators judged the clinical results satisfactory in 60% of the patients in the 1200 mg group (400 mg t.i.d.) 44% of those in the 600 mg group and 36% of those on placebo. The difference is statistically significant (p less than 0.05). Side effects, primarily digestive, were noted in 34% of patients receiving 1200 mg/day, 15% of 600 mg/day and 32% placebo. 2 patients in the 1200 mg group interrupted their treatment for gastralgia and 1 patient on placebo for palpitations. | |
| 790937 | Comparison of mouse liver sections and cultured mouse fibroblasts as substrates for the de | 1976 Nov | Immunofluorescent antinuclear antibody tests were performed on selected sera representing various connective-tissue diseases using mouse liver sections and mouse connective-tissue fibroblasts cultivated in vitro. Substrate sensitivities and patterns of staining were compared by indirect immunofluorescent method employing sera from 92 patients. Sensitivity (geometric mean serum endpoint titer) was significantly greater with the cultured cell substrate. This greater sensitivity was also detected with sera from 46 patients with systemic lupus erythematosus (SLE). No significant difference was observed in other clinical groups tested (rheumatoid arthritis, polyarthritis, drug-induced SLE, degenerative joint diseases, and progressive systemic sclerosis). Sera from 107 to 109 normal controls were negative on the mouse fibroblast substrate. The two substrates were equally sensitive in detecting homogenous, peripheral, or speckled patterns of fluorescence in patients' sera having antinuclear activity. Nucleolar staining was observed in only one serum specimen as a minor pattern. Neither substrate demonstrated a predominant immunofluorescent pattern with sera from SLE, polyarthritis, and progressive systemic sclerosis. Sera of patients with clinically diagnosed rheumatoid arthritis, drug-induced SLE, and degenerative joint diseases usually manifested monogeneous staning patterns. However, these differences in staining pattern among the various clinical groups were not statistically significant. The mouse tissue sections of equal specificity and significantly increased sensitivity for the detection of antinuclear antibody. | |
| 3886298 | Relief of morning stiffness: a comparative study of naproxen and ibuprofen. | 1985 | Morning stiffness in 75 patients with mild to moderate rheumatoid arthritis was treated with 1600 mg ibuprofen 4-times daily or 750 mg naproxen twice daily after a placebo-induced flare of this symptom. With the final daily dose of each drug administered at bedtime, both drugs significantly reduced the duration and severity of morning stiffness compared to baseline values but, on average, duration of morning stiffness tended to be shorter for naproxen patients than for ibuprofen patients. No corresponding between-drug difference was found for severity of morning stiffness. | |
| 7416814 | DNA synthesis in human rheumatoid and nonrheumatoid synovial lining. | 1980 Jun | The DNA content per nucleus has been measured in the lining cells of 12 specimens of rheumatoid and 12 of nonrheumatoid synovial tissue. Optimal conditions for this reaction on these cells have been defined, and an index of DNA synthesis has been applied to give a quantitative measure of the degree of synthesis. This has given evidence of some DNA synthesis in both types of synoviocytes, compatible with the amount found in a slowly self-replacing tissue. There was no difference in the amount of synthesis in the rheumatoid and nonrheumatoid synoviocytes. | |
| 54050 | Diagnosis of systemic lupus erythematosus. Importance of antinuclear antibody titers and p | 1975 Oct | Titers and patterns of antinuclear antibodies (ANA) in sera from 134 normal blood donors, 20 patients with rheumatoid arthritis, 15 patients with systemic scleroderma, and 32 patients with diagnosed or suspected systemic lupus erythematosus (SLE) were studied. The difference between the findings with sera of patients with SLE and normal subjects in terms of high (greater than 160) titers of ANA was greater than in terms of peripheral staining patterns. However, in comparing sera from patients with SLE with sera from patients with other connective tissue diseases, greater differences were found in the incidence of peripheral patterns of ANA compared to differences in the frequency of high ANA titers. Maximum specificity in the diagnosis of SLE was achieved when both titers and patterns of ANA were considered. | |
| 6493942 | The limits of verbal pain descriptors. | 1984 Aug | The evidence that verbal descriptors can reliably portray the sensory and affective qualities of pain states and various clinical groupings of pain patients is examined. Support for the proposition that different pain syndromes can be distinguished on the basis of such word patterns is lacking. | |
| 3885424 | A comparative study of isoxicam and naproxen in rheumatoid arthritis. | 1985 Mar 23 | A 4-week parallel-group, double-blind comparison of isoxicam 200 mg once daily and naproxen 250 mg 3 times daily was carried out on 30 patients with classic or definite rheumatoid arthritis. Fifteen patients were randomly assigned to each treatment group. The articular index, scoring on a pain scale and morning stiffness were significantly reduced after 2 and 4 weeks of treatment with both drugs. Grip strength was significantly increased after 4 weeks of naproxen treatment. The mean increase in grip strength was also comparable in isoxicam-treated patients, but did not reach statistical significance. Joint swelling and walking times showed improvement in both groups. One patient withdrew from isoxicam treatment with a pruritic rash considered to be drug-related and another stopped taking isoxicam because of dizziness, nausea and vomiting--also probably drug-related. Eight other patients, 4 treated with isoxicam and 4 with naproxen, reported adverse reactions associated with the digestive system. In this study isoxicam 200 mg taken once daily was similar in efficacy to and was associated with a similar incidence of adverse reactions as naproxen 250 mg taken 3 times daily. Both drugs were effective in the treatment of rheumatoid arthritis and were well tolerated. | |
| 457295 | Paul-Bunnell antigen in malignancies and rheumatoid arthritis. | 1979 | By means of agglutination inhibition test, Paul-Bunnell (P-B) antigen was demonstrated in sera of patients with cancer (5%), lymphomas or leukemias (12.5%) and rheumatoid arthritis (RA) (1.4%) as well as in synovial fluids from RA patients (27%). In contrast, none of 124 normal human sera gave positive results. P-B antigen was also demonstrated in 3 of 12 perchloric acid extracts of cancer tissues and 2 of 11 saline extracts obtained at 100 degrees C from spleens of lymphoma-leukemia patients. Extracts of apparently normal tissues from 16 individuals gave negative results. | |
| 7471130 | Safety and efficacy of feprazone for long-term treatment of rheumatoid arthritis and osteo | 1981 | Long-term safety and efficacy of feprazone (4-prenyl-1,2-diphenyl-3,5-pyrazolidinedione), an antirheumatic drug that is well tolerated in the gastrointestinal tract, were assessed in a noncontrolled multicenter trial. Administered at a daily dosage of 600 mg for a mean duration of 114.1 days, feprazone was well tolerated by 43 (77%) of 56 treated subjects. Thirteen patients reported side effects, but only five discontinued treatment. The side effects were generally mild and occurred in the first weeks of therapy. Feprazone was found effective after one month on both considered indices of disease activity: Ritchie index (articular index for assessment of joint tenderness) and corticosteroid consumption. | |
| 6343817 | Detection of IgM antibodies to measles virus by enzyme-immunoassay. | 1983 | A method of solid-phase enzyme-immunoassay (EIA) with horseradish-peroxidase-conjugated anti-mu-globulin was used to determine IgM antibodies to measles virus in human sera. Antigens prepared from measles-infected and noninfected Vero cells passively adsorbed to polystyrene cuvettes were both important for the tests, because sera from many patients convalescing from viral infections and sera from rheumatoid arthritis patients were able to bind to control antigen. Sera from measles patients, patients with other viral infections, rheumatoid arthritis (RA) patients, and from blood donors were tested in a dilution of 1:200. Almost all of the acute-phase measles sera (37/38) were positive. The first measles-IgM-negative specimen was found 9 weeks after the onset of rash. Seven percent (15/213) of patients with other viral infections gave positive results in these IgM tests. False-positive reactions were also found in 33 of 51 (65%) sera from RA patients. This nonspecific binding could be abolished by absorptions with latex-IgG particles. This treatment did not have any effect on specific IgM. The IgM-EIA test developed for measles virus antibodies, which requires only a single serum specimen, appears to be a useful diagnostic method for routine virus laboratories. | |
| 7118969 | Methylmethacrylate stabilization for enhancement of posterior cervical arthrodesis in rheu | 1982 Sep | Stainless-steel wire, titanium mesh, and perforated titanium sheets and methylmethacrylate were used in conjunction with autogenous iliac-bone grafts to provide immediate stability in difficult or long posterior cervical fusions in eleven patients with rheumatoid arthritis, who were followed for three to 12.5 years. Two surgical techniques, using methylmethacrylate and metal supplementation of a traditional posterior cervical arthrodesis, are described. One technique includes the occiput, while the other consists of a long posterior fusion that excludes the occiput. In ten of the eleven patients, permanent radiographic stability was maintained as well as a significant reduction of pain and resolution of neural dysfunction. In the eleventh patient a cervical subluxation developed at the distal end of the rigidly fused segment, and eventually the patient died. Four patients who were seen early in the series had wound dehiscences, two of which were infected. Subsequently the methacrylate-metal composite was reduced in volume, and this problem did not recur. In summary, this technique has provided immediate internal splinting and avoided bulky external-fixation devices. It was most useful in fusions of the occiput to the upper part of the cervical spine, in long posterior cervical arthrodesis, and for the repair of pseudarthroses when traditional arthrodesis techniques had failed. | |
| 7102283 | Freeman-Swanson arthroplasty of the knee in rheumatoid arthritis: a 2--7 years experience. | 1982 Aug | Sixty-six Freeman-Swanson arthroplasties were performed on 59 patients with rheumatoid arthritis from 1972 through 1979. The patients were followed prospectively and longitudinally. Thus, a detailed protocol was filled out preoperatively and once a year thereafter. This report is based on a total of 299 observations, with a follow-up period ranging from 2 to 7 years (mean 4.4 years). Pain was the main indication for surgery and relief of pain the most gratifying and consistent finding over the years. Of 56 knees remaining in the study in 1979, 61 per cent were considered to be good, 27 per cent satisfactory, and 12 per cent were failures. Early complications were observed in 20 per cent of the knees, late complications in 24 per cent. The majority of the complications resolved after treatment but six knees (9 per cent) deteriorated following a late complication. Thirteen reoperations were performed, of which five were prosthetic revisions. In conclusion, the results were good over a 7-year period provided the deformity was corrected, stability restored and the prosthetic components positioned perpendicular to the mechanical axis of the leg. Tibial component loosening was the most important reason for failure. | |
| 7377857 | Faecal carriage of klebsiella by patients with ankylosing spondylitis and rheumatoid arthr | 1980 Feb | In consecutive samples submitted to a clinical microbiology laboratory 22 out of 99 from outpatients and 23 out of 51 from inpatients yielded Klebsiella sp. A clinical reassessment of outpatients with ankylosing spondylitis (AS) and rheumatoid arthritis (RA) who had not been inpatients within the last year was made for disease activity and drug requirements. 124 patients with AS and 92 with RA were requested at assessment to submit a stool specimen for klebsiella examination, this being carried out without disclosure of the patient's clinical category. Two months later a questionnaire on symptom changes was collected and the results correlated with klebsiella carriage. Eighty-nine patients with AS and 82 patients with RA fulfilled all criteria for assessment. Of those assessed, 24 out of 89 AS patients and 26 out of 82 RA patients had klebsiella in the faeces. There was no correlation betweeh the initial clinical assessment category and klebsiella carriage. Seventy patients with AS and 57 paients with RA had no change in symptoms over the 2-month period. Nineteen AS patients and 31 RA patients noted symptom improvement or worsening. Of these, 3 AS and 10 RA patients had klebsiella in their faeces. There was no correlation between worsening of symptoms over a 2-month period and klebsiella carriage at initial assessment. | |
| 6700829 | [Capillaroscopic studies in connective tissue inflammations]. | 1984 Jan 28 | Capillarioscopy has been unjustifiably neglected in the study of connective tissue diseases, where examination of the microcirculation is clearly important. A study of 80 cases is reported. 12 systemic lupus, 11 progressive systemic sclerosis (PSS), 20 rheumatoid arthritis (including 3 juvenile and 2 Still's disease); 9 Raynaud's disease (of which 3 idiopathic, 4 with rheumatoid arthritis and 2 with UCTD); 1 dermatomyositis; 11 other CTD (2 overlap syndrome--1 lupus + dermatomyositis; 1 lupus + PSS--3 Sjögren syndromes with rheumatoid arthritis, 1 MCTD, 2 primary mixed cryoglobulinaemia, 1 systemic vasculitis, 1 Behçet syndrome, and 1 UCTD); 9 miscellaneous forms (3 psoriatic arthropathy, 1 rheumatic pelvispondylitis, 1 allergic dermatitis, 1 pulmonary TB, 1 ulcerative colitis; 1 scapulohumeral periarthritis, 1 unclassifiable rheumatism; 7 healthy subjects). During capillarioscopy, from one to nine slides were prepared for each subject. These were interpreted separately by three persons who were unaware of the respective diagnosis. Calibre, tortuosity, length and number of capillaries were recorded, plus the visibility of the subpapillar plexus, height and number of the termal, subungual and/or ungual vallum haemorrhage, plugging. It was found that PSS, dermatomyositis, MCTD, and overlap-PSS revealed a very typical common pattern, possibly pathognomonic, namely marked reduction in the number of capillaries + megacapillaries. The other forms presented less evocative diagnostic patterns, though they were fairly indicative in some instances. Clinical correlations of particular significance with respect to prognosis, however, were not observed. | |
| 596948 | Polymyalgia rheumatica. Assessment of disease activity using erythrocyte sedimentation rat | 1977 Dec | Comparison of clinically assessed activity of disease with 112 paired readings of the erythrocyte sedimentation rate (ESR) and the plasma viscosity (PV) in 23 patients with polymyalgia rheumatica (PMR) showed the following. (1) A correlation between ESR and PV in both sexes, reaching the significance obtained in a comparison group of patients with rheumatoid arthritis (RA) (109 paired readings), with no significant difference between the PMR and RA groups on analysis of variance of the regression slopes. (2) A degree of scatter of readings around the regression lines so that they could not be used for prediction of ESR from the PV or vice versa. (3) varkappa(2) analysis of normal and abnormal values of ESR and PV which showed a highly significant correlation. However 10 readings were abnormally high for ESR in the presence of a normal PV. 5 of these 10 observations were associated with clinical features of disease activity. 20 readings were abnormally high for PV in spite of a normal ESR with only one instance of clinical activity. These data indicate that it is not possible to provide exact guidelines for a ;safe' level of ESR or PV applicable to the individual patient, and measurement of both these indices of disease activity is recommended. | |
| 615416 | Electron transporting enzymes of rheumatoid connective tissue. | 1977 | The oxidative enzyme system of the synovial membrane and rheumatoid node from rheumatoid arthritic patients has been studied by histochemical and biochemical methods. As compared to the control synovial membranes, succinic dehydrogenase activity was substantially higher in the rheumatoid arthritic synovial membranes, and was still higher in the rheumatoid nodes, in which only the cells forming the palisade had succinic dehydrogenase activity. As compared to the controls, in response to menadione succinic dehydrogenase was significantly activated. The reducible ubiquinone content of the rheumatoid synovial membrane and the rheumatoid node was by several orders of magnitude higher than in the controls. |