Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 6394758 | A controlled two-centre trial of parenteral methotrexate therapy for refractory rheumatoid | 1984 Dec | Forty-eight patients with rheumatoid arthritis refractory to other treatments were studied in a placebo controlled trial of methotrexate (MTX) in 2 institutions. Once weekly for 6 weeks, the patients were injected with placebo (Group 1), MTX 10 mg (Group 2), or MTX 25 mg (Group 3). Then, for the next 6 weeks, Group 1 received MTX, either 10 or 25 mg/wk, and Groups 2 and 3 continued their same dose. Adverse reactions necessitated change from 25 mg to 10 mg in some patients, but no major side effects of MTX were noted. At 6 weeks, the effect of the 2 MTX doses did not differ significantly but patients on MTX had fared significantly better (p less than 0.005 - less than 0.001) than those given placebo. At 12 weeks, all indices showed significant improvement in Group 1 and maintenance or enhancement of the improvement in Groups 2 and 3. We conclude that weekly low dose MTX therapy is efficacious for refractory rheumatoid arthritis. | |
| 7016450 | Six-month, double-blind comparison of sodium meclofenamate ("Meclomen') with buffered aspi | 1981 | Sodium meclofenamate (200 to 400 mg daily) was compared with aspirin (2.4 to 4.8 g daily) for the treatment of rheumatoid arthritis in a 6-month, double-blind, multicentre study. Two groups of patients participated, one receiving stabilized doses of concomitant gold or steroid therapy and one not receiving such therapy. In these latter patients, sodium meclofenamate appeared to be more effective than aspirin; tenderness was reduced from 35% to 50% more on sodium meclofenamate throughout the study, the differences being statistically significant during the first 2 months, and over all condition improved in a significantly greater proportion of the patients receiving sodium meclofenamate. Among the patients receiving concomitant gold or steroid, neither drug appeared to be as effective as in the group not receiving the concomitant therapy and the results with both aspirin and sodium meclofenamate were virtually the same for all measures. With sodium meclofenamate the most common adverse reaction was diarrhoea; and with aspirin, it was tinnitus. The incidence of withdrawals for adverse reactions did not differ significantly between the two medication groups. Abnormal laboratory values were observed in a few patients, but the incidence did not differ between the groups. On the basis of the study, sodium meclofenamate appears to be relatively well tolerated and at least as effective as aspirin in the treatment of the symptoms of rheumatoid arthritis. | |
| 6617031 | Fusion of the cervical spine for instability. | 1983 Oct | The orthopedic and neurosurgical literature is neither clear nor consistent in describing an unstable cervical spine. In a series of 25 patients treated by arthrodesis of the cervical spine for instability, 12 had Gallie fusions at the atlantoaxial level. Eight of those fusions were performed for rheumatoid arthritis. In three patients persistent subluxation of the atlas on the axis occurred because the wires were not fully tightened in areas of poor-quality bone. Stable fixation with relief of symptoms was achieved in all patients who had fusions at the subaxial level. Several of these patients had had prolonged nonsurgical treatment. With rheumatoid bone of poor quality, the surgeon must be very careful to tighten the wires only enough to secure a stable reduction for treatment of subaxial cervical instability. Since stability achieved by healing of soft tissue is generally unreliable, prolonged periods of nonsurgical treatment are not justified for traumatic instability. | |
| 7362682 | HLA antigens and rheumatoid arthritis. Association between HLA-DRw4 positivity and IgM rhe | 1980 Mar | Serologic HLA typing was carried out on 33 seropositive and 15 seronegative patients with rheumatoid arthritis (RA). Association with the DRw4 antigen was found only in seropositive RA (61%, compared with 27% in normal controls; P less than 0.05, Fisher's exact test), whereas the antigen had a normal frequency in seronegative RA patients (27%). The serum concentrations of IgM and IgE immunoglobulins were significantly higher in seropositive than in seronegative RA patients (p less than 0.01, Mann-Whitney test), whereas the concentrations of the other immunoglobulin classes and of the complement factors C3 and C4 did not show any significant differences. | |
| 6312608 | The neutrophil in rheumatoid arthritis: its role and the inhibition of its activation by n | 1983 Aug | The activation of the polymorphonuclear leukocyte (PMN) in rheumatoid arthritis produces toxic products that include lysosomal enzymes, stable prostaglandins, and leukotrienes and causes the release of superoxide anion. These products produce the inflammatory response, damage cell membranes, and degrade hyaluronic acid. The inhibition of prostaglandin synthetase by NSAIDs does not, by itself, account for their effectiveness in preventing inflammation in rheumatoid arthritis. In vivo and in vitro experiments were conducted to determine if NSAIDs also exert an effect on neutrophil activation. The NSAIDs tested inhibited discrete PMN functions dependent upon the stimulus tested. The antiinflammatory effects of NSAIDs cannot be entirely explained by their inhibition of prostaglandin synthetase and may, in part, be due to other direct effects upon inflammatory cell activation. | |
| 6509946 | Three-dimensional vector graphics: a method for displaying results in a drug trial. | 1984 Dec | Three-dimensional computer graphics are used to depict multidimensional outcome measures in a clinical drug trial. This graphics approach was used in a study of 116 patients with active rheumatoid arthritis, in a randomized, double-blind 21-week comparison of placebo, oral gold, and injectable gold. Three health status components, physical disability, psychological status, and pain, were generated using the Arthritis Impact Measurement Scales (AIMS). Results were presented in a three-axis perspective, one axis for each component, plotting individual patient vectors for magnitude and direction on a 10 X 10 X 10 coordinate matrix. Vectors for each patient are plotted from time 1 (start) to time 2 (finish) over the 21-week trial period. Vector symbols were added for clarity and subgroup delineation. Vector displays show trends in treatment response that clarify and strongly reinforce the statistical results. It is concluded that three-dimensional vector graphics are a useful adjunct to the statistical analysis of clinical trial results. The graphics facilitate the visual interpretation of a complex data set, and clarify the analysis of the results for both the clinician and researcher. | |
| 6261781 | Metabolic alterations in the synoviocytes in chronically inflamed knee joints in immune ar | 1981 Feb | The metabolism of the synovial lining cells of the normal and chronically inflamed joints of rabbits, in the Dumonde and Glynn model of rheumatoid arthritis, has been examined by quantitative cytochemistry. Significant alterations in metabolic activity were found in the synovial lining cells of the chronically inflamed joints. These alterations in metabolic activity closely resemble the pattern of metabolic changes found in human synovial lining cells in rheumatoid arthritis. | |
| 6744738 | Wrist arthrography. | 1984 Jul | Wrist arthrography can be helpful in the evaluation of the chronically painful wrist and, more specifically, in visualization of the integrity of the triangular fibrocartilage and interosseous ligaments. To be meaningful, arthrographic findings, i.e., compartment communication, synovial irregularity, tendon sheath and lymphatic visualization, loose bodies, and cartilage abnormalities, must be correlated with clinical history and physical examination. | |
| 6990932 | Comparison of high and low dose cyclophosphamide therapy in rheumatoid arthritis. | 1980 May | Eighty-eight patients with active rheumatoid arthritis from 8 Cooperating Clinics were evaluated in a 32-week controlled, double-blind trial comparing 150 mg daily to 75 mg cyclophosphamide daily. Improvement in the arthritis was seen in both groups, and there were no important differences between the two treatment groups in any of the 8 variables used to measure disease activity. Untoward effects were also similar for the two groups. These results differ from preliminary results reported earlier. | |
| 6239778 | Naproxen and piroxicam. A comparative trial in rheumatoid arthritis. | 1983 | A single-blind crossover trial in 60 patients with rheumatoid arthritis showed that piroxicam, 20 mg daily and naproxen, 500 mg twice daily were comparable in both efficacy and tolerance. | |
| 3984530 | [Liberation of the oxygen radical from peripheral human phagocytes (granulocytes and monoc | 1985 Jan | Monocytes from patients with definite or classical rheumatoid arthritis show a significantly higher release of O2-radicals in the chemiluminescence assay (2925 X 10(3) cpm) than those of healthy volunteers (267 X 10(3) cpm) (p = 0.01). This difference does not appear in a similar test with granulocytes, which in both groups tested show a mean chemiluminescence of 2739 X 10(3) and 2547 X 10(3) cpm. The chemiluminescence of monocytes is clearly time-course dependent: in the morning we saw the least response, at noon the highest. Following our results, corticosteroids lower chemiluminescence significantly (p = 0.05), while non steroidal antirheumatic drugs and long-term therapy with gold compounds, etc., do not affect chemiluminescence. | |
| 6647525 | An improved method of determination of SH group concentration and reactivity in plasma of | 1983 Oct | Plasma SH group concentration and reactivity were determined in man and rat in the sulfhydryl-disulfide exchange reaction with 5-5' dithiobis (2 nitrobenzoic acid) (DTNB). Both parameters were assayed in the same sample using different DTNB concentrations: 1 mM and 0.05 mM DTNB were employed in human and rat plasma, respectively. The method was applied to patients with liver diseases and rheumatoid arthritis with and without treatment with antiinflammatory drugs and to rats after administration of indomethacin or carbon tetrachloride. | |
| 6880407 | A retrospective analysis of drug therapy in patients with rheumatoid arthritis. | 1983 Mar | A retrospective analysis of the pharmacotherapy used in 100 patients during their illness was performed. The method was that of a standardized interview based on a questionnaire. Analysis of the data showed that salicylates still dominate among the first-line antirheumatic drugs, but are gradually being replaced by newer antirheumatic agents. A large number of patients received drugs belonging to the group of pyrazolidine compounds. Basic therapy primarily consisted of chrysotherapy; therapy with antimalarials had to be discontinued due to side effects in a high percentage of cases. An interesting finding is the high number of patients treated in the long term with glucocorticoids with apparently good tolerance. | |
| 7025508 | [Flurbiprofen and indomethacin in chronic polyarthritis and gonarthrosis - a comparative m | 1981 Mar | In two multicenter double-blind cross-over studies efficacy and safety of flurbiprofen and indomethacin were compared. Nineteen patients with rheumatoid arthritis and twenty with osteoarthrosis of the knee were treated. Both drugs were effective and almost equal. Also safety was good, however three patients on indomethacin and one on flurbiprofen had to be withdrawn from the trial because of side-effects. | |
| 386186 | A new simple technique for the identification of antibodies against double stranded DNA: p | 1979 Jul 25 | A new, simplified assay for detecting double stranded DNA antibodies by indirect immunofluorescence using fixed human metaphase chromosomes as substrate is described. The technique has the advantage of ease of preparation, clarity of reading, specificity for double stranded DNA and apparently greater sensitivity than immunofluorescent assays currently available. Thirty of 92 systemic lupus erythematosus sera were found to have double stranded DNA antibodies using the metaphase preparation, compared with 23 positive sera detected with the Crithidia luciliae technique. No double stranded DNA antibodies were detected in 90 sera from patients with rheumatoid arthritis. The human metaphase chromosome assay could replace existing techniques for identification of double stranded DNA antibodies. | |
| 7138601 | Evidence for the local production and utilization of immune reactants in rheumatoid arthri | 1982 Nov | Immunoglobulins, including rheumatoid factors, are produced by the rheumatoid synovial membrane. A significant contribution of the synovial membrane to the total IgG and IgM detected in the synovial fluid has been documented. The present study was designed to examine the contribution of the synovial membrane to the rheumatoid factors detected in the synovial fluid. Analysis of the data demonstrated that the synovial membrane was the source of a significant component of the total synovial fluid IgA rheumatoid factor and IgM rheumatoid factor. While some fluids possessed extremely elevated concentrations of the IgG rheumatoid factor, the data suggested that IgG rheumatoid factor was preferentially reduced, relative to total IgG, by the rheumatoid inflammatory process. These observations suggest a potentially important role for IgG rheumatoid factor in rheumatoid synovitis. | |
| 6107722 | Clinical trials of intra-articular aspirin in rheumatoid arthritis. | 1980 Nov 22 | The effect of the intra-articular injection of acetylsalicylic acid in patients with rheumatoid arthritis was compared with that of hydrocortisone acetate and with that of saline in blind, controlled, clinical trials. All three preparations were effective in relieving pain and improving the range of motion, and no significant differences were demonstrated. The results suggest a need for the re-appraisal of the value of intra-articular administration of synthetic corticosteroids. | |
| 7043710 | A double-blind trial comparing indomethacin sustained release capsules (Indocid-R) with in | 1982 May | A double-blind, controlled and completely randomized trial was conducted in four European rheumatology clinics. Eighty-six patients with a diagnosis of rheumatoid arthritis and prior treatment of at least six months' duration with indomethacin 150 mg/day were studied. Comparisons of the clinical efficacy, tolerability and safety of a new, oral sustained-release formulation of indomethacin were made with a conventional formulation of indomethacin. In all clinical indices of response, the indomethacin sustained-release 75 mg capsule b.i.d. was found to provide relief of symptoms similar to the conventional 50 mg capsule t.i.d. The incidence of overall adverse clinical and laboratory effects was comparable for the two treatments. | |
| 837514 | De subitaneis mortibus. XXIII. Rheumatoid arthritis and ankylosing spondylitis. | 1977 Apr | The conduction system of the heart was carefully examined at necropsy in two cases of rheumatoid arthritis and one of ankylosing spondylitis. All three patients had cardiac electrical instability and two fo the three died suddenly. The electrophysiological abnormalities of the three patients included paroxysmal atrial fibrillation in the first case, sustained atrial fibrillation with complete heart block and escape atrioventricular (A-V) junctional rhythm in the second case, and progressively increasing heart block eventually became complete in the third case. The sinus node exhibited extensive focal degeneration with and without associated inflammation in all three hearts, but the sinus node artery was not remarkably abnormal in any of these. All three hearts had important focal degenerative disease in the A-V node and His bundle, and in each of these there was marked narrowing of the local nutrient arteries, amounting to virtual occlusion in two hearts. The probable relationship of these postmortem histological findings to the electrocardiographic disturbances in each patient is discussed. Abnormalities in the cardiac conduction system of the hearts of these three patients are compared to ones previously reported for disseminated lupus erythematosus, polyarteritis nodosa, and scleroderma heart disease. | |
| 4006390 | Erosive arthritis in a patient with amyloid arthropathy. | 1985 Jun | Amyloid arthropathy is said to be distinguished roentgenographically from rheumatoid arthritis by the absence of joint space narrowing and the absence of articular erosions. We present a patient with multiple myeloma with swelling, stiffness and firm synovial thickening of the wrists, metacarpophalangeal joints and proximal interphalangeal joints whose hand radiographs showed articular erosions of the carpal joints and ulnar styloid and joint space narrowing of the proximal interphalangeal joints and metacarpophalangeal joints. Synovial biopsy of the left wrist showed amyloid deposits with no inflammation. Previous reports of X-ray changes in amyloid arthropathy note preservation of joint spaces or widening. Erosions when noted are of non-articular bone rather than of the articular surface. This is the first case report of erosive articular disease in amyloid arthropathy. |